Behçet's Disease With Intestinal Perforation: A Case Report

Maggiora, Maricel Della; Baños, Andrea; Paolini, Virginia; Florio, Dario; Takashima, Lorena; Aicardi, Pedro

doi:10.1016/j.reumae.2016.03.011

Cited by 2 publications

(1 citation statement)

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“…To date, few data are available regarding ADA efficacy in GIBD, although the proofs of its usefulness are increasing [ 86 – 88 ]. In this regard, ADA has been already successfully used in three patients with BD-related colitis/esophageal ulcers [ 89 ] and for the first time in the context of a familial case of GIBD [ 90 ].…”

Section: The Management Of Gibdmentioning

confidence: 99%

Update on the Medical Management of Gastrointestinal Behçet’s Disease

Lopalco

Rigante

Venerito

et al. 2017

Mediators of Inflammation

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Behçet's disease (BD) is a multisystemic disorder of unknown etiology mainly defined by recurrent oral aphthosis, genital ulcers, and chronic relapsing bilateral uveitis, all of which represent the “stigmata” of disease. However, many other organs including the vascular, neurological, musculoskeletal, and gastrointestinal systems can be affected. The gastrointestinal involvement in Behçet's disease (GIBD), along with the neurological and vascular ones, represents the most feared clinical manifestation of BD and shares many symptoms with inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Consequently, the differential diagnosis is often a daunting task, albeit the presence of typical endoscopic and pathologic findings may be a valuable aid to the exact diagnosis. To date, there are no standardized medical treatments for GIBD; therefore therapy should be tailored to the single patient and based on the severity of the clinical features and their complications. This work provides a digest of all current experience and evidence about pharmacological agents suggested by the medical literature as having a potential role for managing the dreadful features of GIBD.

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