Being Well Informed Is Critical to Informed Consent for Living Liver Donors

Berg, Carl L.

doi:10.1097/tp.0000000000003959

Cited by 1 publication

(1 citation statement)

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“…When it comes to living organ donors, ensuring their understanding of the surgery’s risks, benefits and potential complications is crucial, especially during the informed consent process. Comprehensive discussions on short-term and long-term outcomes should take place at this stage[ 97 ]. There is notable regional variability in the application and acceptance of MELD exceptions for LT. A study revealed that, despite OPTN’s clinical criteria, nearly 80% of exception applications for PSC and cholangitis were approved by regional review boards regardless of the indication[ 98 ].…”

Section: Discussionmentioning

confidence: 99%

Liver transplant in primary sclerosing cholangitis: Current trends and future directions

Shah,

Nombera-Aznaran,

Guevara-Lazo

et al. 2023

World J Hepatol

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Primary sclerosing cholangitis (PSC) is a chronic and progressive immune-mediated cholangiopathy causing biliary tree inflammation and scarring, leading to liver cirrhosis and end-stage liver disease. Diagnosis of PSC is challenging due to its nonspecific symptoms and overlap with other liver diseases. Despite the rising incidence of PSC, there is no proven medical therapy that can alter the natural history of the disease. While liver transplantation (LT) is the most effective approach for managing advanced liver disease caused by PSC, post-transplantation recurrence of PSC remains a challenge. Therefore, ongoing research aims to develop better therapies for PSC, and continued efforts are necessary to improve outcomes for patients with PSC. This article provides an overview of PSC’s pathogenesis, clinical presentation, and management options, including LT trends and future aspects. It also highlights the need for improved therapeutic options and ethical considerations in providing equitable access to LT for patients with PSC. Additionally, the impact of liver transplant on the quality of life and psychological outcomes of patients with PSC is discussed. Ongoing research into PSC’s pathogenesis and post-transplant recurrence is crucial for improved understanding of the disease and more effective treatment options.

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Section: Discussionmentioning

confidence: 99%