Bell's palsy: A 10-year experience with antiphlogistic-rheologic infusion therapy

Sittel, Christian; Sittel, A.; Guntinas‐Lichius, Orlando; He, Eckel; Stennert, E.

doi:10.1016/s0196-0709(00)80055-1

Cited by 23 publications

(19 citation statements)

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“…Its neuroprotective effect has been shown in several clinical trials [5,11,12,13,16,26,27] and animal experiments [7,8,9]. We showed in 2014 that nimodipine is capable of protecting undifferentiated Neuro2a cells from cell death caused by mechanical, heat and oxidative stress.…”

Section: Discussionmentioning

confidence: 91%

Nimodipine but Not Nifedipine Promotes Expression of Fatty Acid 2-Hydroxylase in a Surgical Stress Model Based on Neuro2a Cells

Herzfeld

Speh

Strauß

et al. 2017

IJMS

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Nimodipine is well characterized for the management of aneurysmal subarachnoid hemorrhage and has been shown to promote a better outcome and less delayed ischemic neurological deficits. Animal and clinical trials show neuroprotective efficacy following nerve injuries. We showed a neuroprotective effect on Neuro2a cells. Subsequent microarray analysis revealed—among others—fatty acid 2-hydroxylase (FA2H) upregulated by nimodipine in vitro, which is a component of myelin synthesis. Differentiated Neuro2a cells were analyzed for nimodipine-mediated survival considering stress treatment in comparison to nifedipine-treatment. Cell survival was determined by measurement of LDH activity in the culture medium. Nimodipine decreased surgery-like stress-induced cell death of differentiated Neuro2a cells. Neuro2a cell culture was analyzed for changes in FA2H expression induced by nimodipine or nifedipine in surgery-like stress conditions. We analyzed expression levels of FA2H mRNA and protein by qPCR using fa2h specific primers or a FA2H-specific antibody in nimodipine or nifedipine non- and pre-treated Neuro2a cell culture, respectively. Nimodipine but not nifedipine increases FA2H protein levels and also significantly increases mRNA levels of FA2H in both undifferentiated and differentiated Neuro2a cells. Our findings indicate that higher expression of FA2H induced by nimodipine may cause higher survival of Neuro2a cells stressed with surgery-like stressors.

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Section: Discussionmentioning

confidence: 91%

Nimodipine but Not Nifedipine Promotes Expression of Fatty Acid 2-Hydroxylase in a Surgical Stress Model Based on Neuro2a Cells

Herzfeld

Speh

Strauß

et al. 2017

IJMS

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“…It is a controversy also if facial nerve degeneration is associated with diabetes and if diabetic patients are more vulnerable to treatment failure [19,20,21,22,23,24]. …”

Section: Discussionmentioning

confidence: 99%

Independent Role of Hypertension in Bell’s Palsy: A Case-Control Study

2008

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Background/Aim: In this case-control study, our aim was to check for a possible independent role of hypertension in increasing the risk of developing Bell’s palsy. Methods: All patients diagnosed as having Bell’s palsy referred to a neurology clinic were enrolled as cases. Controls were selected among other patients referred to the same clinic. Data were analyzed using the Stata 8 statistical software package. To detect the independent effect of exposure variables, a multiple logistic regression test was used. Results: Bivariate analysis showed an increased risk of Bell’s palsy for patients with diabetes or hypertension. Logistic regression results stratified for patients younger than 40 years of age and others showed that diabetes was the independent predictor of Bell’s palsy in both age groups. Logistic regression results showed that hypertension could not independently predict the occurrence of Bell’s palsy among patients younger than 40 years but for older ones it could. Conclusion: Hypertension may increase the risk of Bell’s palsy among those aged above 40 years. Researchers should be very cautious when declaring an independent role of hypertension as a cause of Bell’s palsy.

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“…Patients with idiopathic facial palsy were treated by infusion therapy with high‐dose prednisolone and pentoxifylline 9 . This regime was combined with acyclovir in patients with Ramsay‐Hunt syndrome.…”

Section: Methodsmentioning

confidence: 99%

Prognostic Value of Electroneurography and Electromyography in Facial Palsy

2008

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Objectives:To compare the prognostic value of electroneurography (ENG) and needle electromyography (EMG) to estimate facial function outcome after acute facial palsy.Study Design: Retrospective study using electrodiagnostic data and medical chart review.Methods: Two hundred one patients treated 1995 to 2004 were included. Initial and final facial function was established clinically by the House-Brackmann (HB) scale. ENG results were classified into amplitude loss less than 75% and amplitude loss 75% or greater to predict complete recovery and defective healing, respectively. Initial and follow-up EMG results were classified into neurapraxia and predicted complete recovery. In contrast, axonotmesis/neurotmesis and mixed lesions predicted, by definition, defective healing.Results: Initial HB was II to IV in 154 patients and V to VI in 47 patients. The etiology was idiopathic palsy in 139, iatrogenic lesion in 29, traumatic in 18, and herpes zoster in 15 patients. Finally, 134 (67%) patients showed a full recovery. Sixty-seven (33%) patients showed signs of defective healing. ENG presented a sensitivity, specificity, accuracy, positive predictive value (to predict defective healing), and negative predictive value of 60%, 79%, 73%, 59%, and 80%, respectively. The values for the initial EMG were 66%, 98%, 89%, 91%, and 89%. The best results showed the follow-up EMG with 85%, 100%, 97%, 100%, and 96%. EMG results were not classifiable in 32 (16%) patients.Conclusions: EMG showed higher prognostic values than ENG, especially when repeated during the time course of the facial palsy. ENG might be helpful if the EMG result is not classifiable.

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Bell's palsy: A 10-year experience with antiphlogistic-rheologic infusion therapy

Cited by 23 publications

References 0 publications

Nimodipine but Not Nifedipine Promotes Expression of Fatty Acid 2-Hydroxylase in a Surgical Stress Model Based on Neuro2a Cells

Nimodipine but Not Nifedipine Promotes Expression of Fatty Acid 2-Hydroxylase in a Surgical Stress Model Based on Neuro2a Cells

Independent Role of Hypertension in Bell’s Palsy: A Case-Control Study

Prognostic Value of Electroneurography and Electromyography in Facial Palsy

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