Innovations in high-speed rail (HSR) have had substantial effects on different stakeholders within and outside the railway system. As part of the European Shift2Rail research programme, several innovative solutions are developed for, among others, improving the HSR infrastructure. The Joint Undertaking behind this research program has set objectives for these innovations in terms of punctuality, capacity, and life cycle costs. With a focus on infrastructure-related innovations for HSR, this paper aims at assessing their impacts in relation to these targets. We review the relevant research literature about the effects of HSR innovations and their assessment. The paper presents a hybrid assessment methodology combing different approaches to assess capacity, punctuality, and cost effects. This contributes to reducing the existing gap that is found in the research literature. Based on a reference scenario for HSR line and collected data from different stakeholders, the results indicate that infrastructure innovations in HSR, being developed within the European Shift2Rail research programme, can contribute to reaching the target set for punctuality. Further innovations in HSR infrastructure and/or other railway assets may be needed to reach additional targets and for more accurate improvement values giving more insights into their impacts.