Beneficial effects of Anadenanthera colubrina (Vell.) Brenan extract on the inflammatory and nociceptive responses in rodent models

Santos, Jessica Silva; Marinho, Renata Ribeiro; Ekundi-Valentim, Eduardo; Rodrigues, Lucas Fonseca; Yamamoto, Marcos Kazuo; Teixeira, Simone Aparecida; Muscará, Marcelo N.; Costa, Soraia K.P.; Thomazzi, Sara Maria

doi:10.1016/j.jep.2013.04.012

Cited by 35 publications

(22 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the phytochemical screening of the bark of A. colubrina, authors have found catechins, flavonoids, phenols, saponins, steroids, tannins, triterpenes, and xanthones, suggesting the participation of secondary metabolites in the biological activity of this plant [23]. In the present study, polyphenols accounted for 53.18% of the extract.…”

Section: Discussionsupporting

confidence: 54%

“…The bark of this tree is reported to have effective action as an anti-inflammatory agent with peripheral antinociceptive activity, indicating the existence of compounds with potential for the development of drugs for the treatment of inflammation and pain [23]. The present findings indicate the antifungal potential of this plant, as the extract and its active fraction inhibited the growth of Candida albicans (MIC = 0.31 mg/mL), demonstrating strong antimicrobial activity [24].…”

Section: Discussionmentioning

confidence: 60%

See 1 more Smart Citation

Antimicrobial and Antiproliferative Potential of Anadenanthera colubrina (Vell.) Brenan

Lima

Alves

Rosalen

et al. 2014

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

The aim of the present study was to perform an in vitro analysis of the antimicrobial and antiproliferative potential of an extract from Anadenanthera colubrina (Vell.) Brenan (angico) and chemically characterize the crude extract. Antimicrobial action was evaluated based on the minimum inhibitory concentration (MIC), minimum bactericidal/fungicidal concentration, and the inhibition of formation to oral biofilm. Cell morphology was determined through scanning electron microscopy (SEM). Six strains of tumor cells were used for the determination of antiproliferative potential. The extract demonstrated strong antifungal activity against Candida albicans ATCC 18804 (MIC = 0.031 mg/mL), with similar activity found regarding the ethyl acetate fraction. The extract and active fraction also demonstrated the capacity to inhibit the formation of Candida albicans to oral biofilm after 48 hours, with median values equal to or greater than the control group, but the difference did not achieve statistical significance (P > 0.05). SEM revealed alterations in the cell morphology of the yeast. Regarding antiproliferative activity, the extract demonstrated cytostatic potential in all strains tested. The present findings suggest strong antifungal potential for Anadenanthera colubrina (Vell.) Brenan as well as a tendency toward diminishing the growth of human tumor cells.

show abstract

Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 60%

Antimicrobial and Antiproliferative Potential of Anadenanthera colubrina (Vell.) Brenan

Lima

Alves

Rosalen

et al. 2014

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Recent studies have shown that A. colubrina has promising therapeutic properties, such as antifungal, 18,19,20 anti-inflammatory and antinociceptive activities 21 , the last two having been confirmed in an animal model. In a previous study, our group verified that A. colubrina has a strong antifungal potential against C. albicans, inhibiting biofilm formation with changes in its morphology.…”

Section: Introductionmentioning

confidence: 96%

Anadenanthera Colubrina vell Brenan: anti-Candida and antibiofilm activities, toxicity and therapeutical action

et al. 2019

View full text Add to dashboard Cite

We evaluated the antifungal and antibiofilm potential of the hydroalcoholic extract of bark from Anadenanthera colubrina (vell.) Brenan, known as Angico, against Candida spp. Antifungal activity was evaluated using the microdilution technique through the Minimum Inhibitory and Fungicide Concentrations (MIC and MFC). The antibiofilm potential was tested in mature biofilms formed by Candida species and analyzed through the counting of CFU/mL and scanning electron micrograph (SEM). In vivo toxicity and therapeutic action was evaluated in the Galleria mellonella model. The treatment with the extract, in low doses, was able to reduce the growth of planktonic cells of Candida species. MIC values range between 19.5 and 39 µg/mL and MFC values range between 79 and 625 µg/mL. In addition was able to reduce the number of CFU/mL in biofilms and to cause structural alteration and cellular destruction, observed via SEM. A. colubrina showed low toxicity in the in vivo assay, having not affected the viability of the larvae at doses below 100mg/kg and high potential in the treatment of C. albicans infection. Considering its high antifungal potential, its low toxicity and potential to treatment of infections in in vivo model, A. colubrina extract is a strong candidate for development of a new agent for the treatment of oral candidiasis.

show abstract

“…A. colubrina stands out due its medicinal properties, which include the application for treatment of inflammatory disorders in different tissues [13,14]. Several studies have shown the various pharmacological properties of products derived from A. colubrina (mostly extracts and fractions from the leaves and roots) that include antimicrobial [12,15,16], antioxidant [17][18][19][20], wound-healing [21,22], anti-inflammatory [23], antinociceptive [24], and antiproliferative properties [18,25]. Despite the therapeutic potential, little information is available regarding the chemical properties and biological activities of the biopolymer extracted from the trunk exudate of A. colubrina, the red angico gum (RAG), of northeast Brazil.…”

Section: Introductionmentioning

confidence: 99%

Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment

Araújo

Oliveira²,

Sousa

et al. 2020

Pharmaceuticals

View full text Add to dashboard Cite

Anadenanthera colubrina var. cebil (Griseb.) Altschul (Fabaceae family), commonly known as the red angico tree, is a medicinal plant found throughout Brazil’s semi-arid area. In this study, a chemical analysis was performed to investigate the antidiarrheal activity and safety profile of red angico gum (RAG), a biopolymer extracted from the trunk exudate of A. colubrina. Upon FT-IR spectroscopy, RAG showed bands in the regions of 1608 cm−1, 1368 cm−1, and 1029 cm−1, which relate to the vibration of O–H water molecules, deformation vibration of C-O bands, and vibration of the polysaccharide C-O band, respectively, all of which are relevant to glycosidic bonds. The peak molar mass of RAG was 1.89 × 105 g/mol, with the zeta potential indicating electronegativity. RAG demonstrated high yield and solubility with a low degree of impurity. Pre-treatment with RAG reduced the total diarrheal stool and enteropooling. RAG also enhanced Na+/K+-ATPase activity and reduced gastrointestinal transit, and thereby inhibited intestinal smooth muscle contractions. Enzyme-Linked Immunosorbent Assay (ELISA) demonstrated that RAG can interact with GM1 receptors and can also reduce E. coli-induced diarrhea in vivo. Moreover, RAG did not induce any signs of toxicity in mice. These results suggest that RAG is a possible candidate for the treatment of diarrheal diseases.

show abstract

Beneficial effects of Anadenanthera colubrina (Vell.) Brenan extract on the inflammatory and nociceptive responses in rodent models

Cited by 35 publications

References 22 publications

Antimicrobial and Antiproliferative Potential of Anadenanthera colubrina (Vell.) Brenan

Antimicrobial and Antiproliferative Potential of Anadenanthera colubrina (Vell.) Brenan

Anadenanthera Colubrina vell Brenan: anti-Candida and antibiofilm activities, toxicity and therapeutical action

Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment

Contact Info

Product

Resources

About