Beneficial Effects of Prostaglandin E 1 on Ischemic Colitis Following Surgery on the Abdominal Aorta

Nakai, Masatsugu; Uchida, Hatsuzo; Hanaoka, Toshihito; Sugiyama, Satoru; Sano, Shunji; Shimizu, Nobuyoshi

doi:10.1007/s005950050302

Cited by 8 publications

(4 citation statements)

References 11 publications

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“…However, the treatment was not effective and the following colonoscopy showed that the patient's condition had worsened. Other reports describe the effect of PGE1 (intra‐arterial or intravenous injection) in increasing colonic blood flow 18–20 . In our case, the patient's lesion and symptoms improved progressively after we started intravenous injection of PGE1.…”

Section: Discussionsupporting

confidence: 47%

Prostaglandin E1‐effective, transient‐type ischemic colitis developed after surgical resection of sigmoid colon cancer. A case report

Ishihara¹,

Seike²,

Yokouchi³

et al. 2003

Digestive Endoscopy

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A 55‐year‐old‐man had a laparoscopic resection of the sigmoid colon due to colon cancer with submucosal invasion. After the surgery he suffered ileus and had a laparotomy. Six months later he complained of frequent defecation. Colonoscopy confirmed a circular ulcer extending from the anal side of the anastomosis in the sigmoid colon to the mid rectum. Endoscopic ultrasound demonstrated thickening of all layers of the diseased colon and rectum. We diagnosed ischemic colitis. After intravenous drip infusion of prostaglandin, symptoms and colonic stricture gradually improved. Although abdominal angiography revealed a narrowing of the peripheral sigmoid branch of the inferior mesenteric artery, blood flow was unrestricted. Colonoscopy performed 84 days after discharge revealed an ulcer scar.

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Section: Discussionsupporting

confidence: 47%

Prostaglandin E1‐effective, transient‐type ischemic colitis developed after surgical resection of sigmoid colon cancer. A case report

Ishihara¹,

Seike²,

Yokouchi³

et al. 2003

Digestive Endoscopy

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“…PGE1 has been used to treat ischemic liver damage, 28 ischemic colitis, 29 and cerebral ischemia. 30 However, there were little reports on acute AAN treatment with PGE1.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Prostaglandin E1 on Renal Microvascular Injury in Rats of Acute Aristolochic Acid Nephropathy

Sun

Liu

et al. 2011

Renal Failure

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Background: To investigate the renal microvascular injury in acute aristolochic acid nephropathy (AAN) and the protective effects of prostaglandin E1 (PGE1) in acute AAN. Methods: Female Sprague-Dawley rats were randomly divided into three groups. The rats in PGE1 group received Caulis Aristolochia manshuriensis (CAM) decoction by gavage for 5 days, and PGE1 was given by vena caudalis before gavage. The rats in model group were gavaged with CAM for 5 days, and the same dose of 0.9% physiologic saline was given by vena caudalis. The rats in control group only received an equal daily volume of saline solution by gavage. Animals were killed at days 3, 5, and 7. Blood urea nitrogen (BUN), serum creatinine, and urinary protein were monitored before killing. Microvascular density was determined by JG12 immunostaining. The expression of angiogenic factor was assessed by vascular endothelial growth factor (VEGF). Tubulointerstitial hypoxia was assessed by hypoxia-inducible factor-1a (HIF-1a) expression. Results: CAM induced a significant decrease in VEGF expression and microvascular density in the kidney tissue, accompanied by a significant increase in HIF-1a, which reduced renal function and increased 24-h urinary protein excretion rates. PGE1 lessened the capillary loss, relieved hypoxia, and protected renal function. No significant pathological changes were found in control rats. Conclusion: The renal microvascular injury in acute AAN is severe. PGE1 can significantly ameliorate the renal microvascular injury, relieve hypoxia, and protect renal function.

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“…Ob eine Patientenselektion bei intraoperativem Monitoring mit dopplerflowmetrischen Verfahren einen Vorteil bringen würde, bedarf der Überprüfung (8). Tierexperimentellen Befunden zufolge wäre die Testung der protektiven Effekte von Prostaglandin E1 auch beim Menschen zur Verhinderung der Kolonischämie nach aortaler Chirurgie angezeigt (7).…”

Section: Apparative Untersuchungenunclassified

Durchfälle nach Gefäßrekonstruktion einer aneurysmatischen Bauchaorta

Meibaum¹,

Langwieder²,

Micklefield³

et al. 2003

Dtsch med Wochenschr

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Beneficial Effects of Prostaglandin E 1 on Ischemic Colitis Following Surgery on the Abdominal Aorta

Cited by 8 publications

References 11 publications

Prostaglandin E1‐effective, transient‐type ischemic colitis developed after surgical resection of sigmoid colon cancer. A case report

Prostaglandin E1‐effective, transient‐type ischemic colitis developed after surgical resection of sigmoid colon cancer. A case report

Protective Effect of Prostaglandin E1 on Renal Microvascular Injury in Rats of Acute Aristolochic Acid Nephropathy

Durchfälle nach Gefäßrekonstruktion einer aneurysmatischen Bauchaorta

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