Beneficial or Harmful Effect of Antipaternal Human Leukocyte Antibodies on Pregnancy Outcome? A Systematic Review and Meta‐Analysis

Lashley, Eileen; Meuleman, Tess; Claas, Frans H.J.

doi:10.1111/aji.12109

Cited by 46 publications

(36 citation statements)

References 60 publications

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“…Accordingly, adverse effects associated with vaccine-induced alloimmune responses in humans are more likely to lead to early embryonic loss, miscarriage or chronic conditions. Naturally occurring MHC I specific alloantibodies have been associated with recurrent miscarriage and chronic chorioamnionitis in humans, although studies have given conflicting results [47][48][49]. Early embryonic loss and miscarriage are common in women and nonspecific symptoms add to the complication of monitoring for potential alloimmune related adverse vaccine effects.…”

Section: Expert Commentary -The Safety Of Using Allogeneic Cell Linesmentioning

confidence: 99%

The risks of using allogeneic cell lines for vaccine production: the example of Bovine Neonatal Pancytopenia

Benedictus

Bell

2016

Expert Review of Vaccines

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Introduction: Bovine neonatal pancytopenia (BNP) is a hemorrhagic disease that emerged in calves across Europe in 2007. Its occurrence is attributed to immunization of the calf's mother with a vaccine produced using an allogeneic cell line. Vaccine-induced alloantibodies specific for major-histocompatibility class I antigens are transferred from the mother to the calf via colostrum, leading to profound depletion of peripheral blood and bone marrow cells that is often fatal. Areas covered: Pubmed and Web of Science were used to search for literature relevant to BNP and the use of allogeneic vaccine cell lines. Following a review of the pathology and pathogenesis of this novel condition, we discuss potential risks associated with the use of allogeneic vaccine cell lines. Expert commentary: Although BNP is associated with a specific vaccine, it highlights safety concerns common to all vaccines produced using allogeneic cell lines. Measures to prevent similar vaccineinduced alloimmune-mediated adverse events in the future are discussed.

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Section: Expert Commentary -The Safety Of Using Allogeneic Cell Linesmentioning

confidence: 99%

The risks of using allogeneic cell lines for vaccine production: the example of Bovine Neonatal Pancytopenia

Benedictus

Bell

2016

Expert Review of Vaccines

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“…[15][16][17][18][19] However, the degree and duration of the sensitization depends on the immunological history of the patient and the reason of the sensitization. 20 It was detected that 20% of healthy subjects and 50% of transplantation candidates have anti-HLA antibodies.…”

Section: Importance Of the Anti-hla Antibodies In Transplantationmentioning

confidence: 99%

“…On the other hand, 30% of patients might have donor specific antibodies. [10][11][12][13][14][15][16][17][18][19][20][21] Rejections defined in renal, cardiac and pancreas transplantations and history of rejection differs from organ to organ. 10 If alloantibody formation is supported by memory T cell response, and alloantibodies against HLA antigens of donor tissues are generated, hyperacute rejection may occur in the early phase after transplantation.…”

Section: Importance Of the Anti-hla Antibodies In Transplantationmentioning

confidence: 99%

“…In addition, fetal cells, fetal DNA and apoptotic cell debris flow into the blood circulation. 15 Antigen presenting cells could be triggered by any of these particles for antigen presentation. 28 …”

Section: Transfer Of Maternal Antibodies Through Placentamentioning

confidence: 99%

“…However, the mechanism of this tolerance cannot be explained clearly. 15,29,30 This tolerance can be permanent or temporary. But it has been established that the key point of the maternal-fetal tolerance is the induction of genes that inhibit the immune response by selective inhibition of the placental genes that activate the maternal immune system.…”

Section: Maternal Tolerancementioning

confidence: 99%

See 2 more Smart Citations

Importance of Pregnancy Induced Paternal HLA Antibody Production in Transplantation: Review

Gürbüz¹,

Soyöz²,

Ayna³

et al. 2016

Turkiye Klinikleri J Med Sci

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Genetic and non‐genetic risk factors for pre‐eclampsia: umbrella review of systematic reviews and meta‐analyses of observational studies

Giannakou

Εvangelou

Papatheodorou

2018

Ultrasound in Obstet & Gyne

104

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Short title: Genetic and non-genetic risk factors for preeclampsia Keywords: Preeclampsia, Risk factors, Epidemiology, Meta-analysis, Umbrella reviewThis article is protected by copyright. All rights reserved.This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/uog.18959 Accepted Article AbstractObjective: To summarize evidence from the literature on the risk factors associated with preeclampsia, assess the presence of statistical biases and identify associations with robust evidence. Methods:We searched PubMed and ISI Web of Science from inception to October, 2016, to identify systematic reviews and meta-analyses of observational studies examining associations between genetic and non-genetic risk factors for preeclampsia.For each meta-analysis we estimated the summary effect size by random-effects and fixed-effects models, the 95% confidence interval and the 95% prediction interval. We estimated the between-study heterogeneity expressed by I 2 (considering above 75% as very large), evidence of small-study effects (large studies had significantly more conservative results than smaller studies and evidence of excess significance bias (too many studies with statistically significant results).Results: Fifty-seven eligible papers were identified providing data on 130 associations including 1466 primary studies, covering a very wide range of risk factors: co-morbid diseases, genetic factors, exposure to environmental agents and a range of biomarkers.Sixty-five (50%) associations had nominally statistically significant findings at P<0.05, while sixteen (12%) were significant at P<10 -6 . Sixty-four (49%) associations had large or very large heterogeneity. Evidence for small-study effects and excess significance bias was found in ten (8%) and twenty-six (20%) associations, respectively. Oocyte donation vs normal conception (OR 4.33, 95% CI: 3.11-6.03) had >1000 cases, 95% prediction intervals excluding the null, not suggestive of large heterogeneity (I 2 <50%), small-study effects (P for Egger's test>0.10), or excess of significance (P>0.05

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Beneficial or Harmful Effect of Antipaternal Human Leukocyte Antibodies on Pregnancy Outcome? A Systematic Review and Meta‐Analysis

Cited by 46 publications

References 60 publications

The risks of using allogeneic cell lines for vaccine production: the example of Bovine Neonatal Pancytopenia

The risks of using allogeneic cell lines for vaccine production: the example of Bovine Neonatal Pancytopenia

Importance of Pregnancy Induced Paternal HLA Antibody Production in Transplantation: Review

Genetic and non‐genetic risk factors for pre‐eclampsia: umbrella review of systematic reviews and meta‐analyses of observational studies

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