Benign and malignant odontogenic neoplasms of the jaws show a concordant nondiscriminatory p63/p40 positive immunophenotype

Argyris, Prokopios P.; Malz, Chris; Taleb, Reda; Koutlas, Ioannis G.

doi:10.1016/j.oooo.2018.08.018

Cited by 6 publications

(1 citation statement)

References 37 publications

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“…The negative expression of Nestin in AB is also supported by Fujita et al 54 NF-kB is a molecule of Protein Kinase B (AKT pathway) and is shown to be a putative regulator of local invasiveness of AB. 55 Together with the present finding of increased expression of NF-kB in AC compared to AB suggests further exploration of the predictive potential of this marker in malignant transformation of AB. Although p63 was shown to differentiate between AB and AC, as reported in this study, previous evidence suggested no discriminatory potential of this marker between odontogenic cysts and odontogenic tumors.…”

Section: Discussionsupporting

confidence: 75%

Differential Expression of Immunohistochemical Markers in Ameloblastoma & Ameloblastic Carcinoma: A Systematic Review and Meta-analysis of observational studies

Mishra,

Panda,

Mohanty

et al. 2024

F1000Res

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Background Differentiating between ameloblastoma (AB) and ameloblastic carcinoma (AC) is difficult, especially when AB has atypical cytological characteristics or an uncommon clinical history. This systematic review and meta-analysis aimed to elucidate the differential expression of immunohistochemical markers between AB and AC. Methods We conducted a thorough search of PUBMED and SCOPUS according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to identify cross-sectional studies that compared the expression of immunohistochemical markers in AB and AC. We used a random-effects model to analyze the risk ratios and their corresponding 95% confidence intervals (CIs). The quality of the included studies was assessed using the Newcastle-Ottawa scale. The Egger’s test was used to assess publication bias. Results In total, 301 articles were identified. After excluding irrelevant titles and abstracts, 86 articles were selected for full-text review. We categorized the 41 markers into proliferative and non-proliferative markers. Among non-proliferative markers, nuclear markers were differentially expressed in AB and AC. SOX2 was the only marker that significantly differentiated AB and AC, with an RR of -0.19 (CI 0.10-0.36, I2=0). Conclusion The current evidence suggests the significance of SOX2 in differentiating between AB and AC, warranting prospective confirmation in well-defined extensive studies. We highlight the paucity of high-quality replicated studies of other markers in this field. Collaborative efforts with standardized techniques are necessary to generate clinically useful immunohistochemical markers.

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Section: Discussionsupporting

confidence: 75%