Benign Cellular Responses in Rats to Different Wear Particles in Intra-Articular and Intramedullary Environments

Abstract

Benign cellular responses in rats to different wear particles in intra-articular and intramedullary environments van der Vis, H.M.; Marti, R.K.; Tigchelaar, W.; Schuller, H.M.; van Noorden, C.J.F. Published in:The journal of bone and joint surgery. British volume Link to publicationCitation for published version (APA): van der Vis, H. M., Marti, R. K., Tigchelaar, W., Schuller, H. M., & van Noorden, C. J. F. (1997). Benign cellular responses in rats to different wear particles in intra-articular and intramedullary environments. The journal of bone and joint surgery. British volume, 79, 837-843. General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. We examined the cellular responses to various particles injected into the knees and the intramedullary femoral cavities of rats in the presence of polymethylmethacrylate (PMMA) plugs.The intra-articular particles were mainly ingested by synovial fibroblasts. Increased numbers of macrophages were not detected and there was only a slight increase in synovial thickness.Cellular responses in the intramedullary space were similarly mild and bone resorption around the PMMA plug did not occur. Bone formation was inhibited only by polyethylene particles.In contrast to current views, our study shows that wear particles per se do not initiate bone resorption.

Sealing effect of hydroxyapatite coating: A 12-month study in canines

“…Howie et al (1988) first described PE particle-induced osteolysis in a stable bone-implant interface in an experimental study. A later study (Van Der Vis et al 1997) using the same model, however, could not reproduce the original finding of osteolysis. It can therefore be speculated that other factors are necessary to mediate peri-implant inflammation and osteolysis.…”

Aseptic loosening, not only a question of wear: A review of different theories

“…Based on their find-ings, these authors postulated that particles alone could cause bone resorption in the absence of motion and infection. These results have not been reproduced, however (Howie et al 1993, Van Der Vis et al 1997.…”

“…However, as shown in Table, the amounts and sizes of particles have varied between the different studies (Howie et al 1988, Goodman 1994, Bobyn et al 1995, Dowd et al 1995, Frökjaer et al 1995, Goodman et al 1995, 1999, Kraemer et al 1995, Allen et al 1996, Aspenberg and Herbertsson 1996, Shanbhag et al 1997, Van Der Vis et al 1997, Kim et al 1998, Frökjaer et al 1999, Lalor et al 1999, Brooks et al 2000, Rahbek et al 2000, 2001, Bechtold et al 2001, Bi et al 2001b, Sundfeldt et al 2002. The time of introduction of the particles and the design of the studies also varied greatly.…”

“…It is very difficult to make any clear connection between PE particles and bone resorption based on animal studies (Howie et al 1988, Søballe et al 1992, Bobyn et al 1995, Dowd et al 1995, Allen et al 1996, Van Der Vis et al 1997, Kim et al 1998, Frökjaer et al 1999, Lalor et al 1999, Brooks et al 2000, Rahbek et al 2000, Sundfeldt et al 2002.…”

Fluid pressure may cause periprosthetic osteolysis: Particles are not the only thing

“…However, we have failed to induce bone loss by introducing HDPE particles into a bone implant interface in rats, whereas osteolysis was easily induced by mechanical instability in the same model (Aspenberg and Herbertsson 1996). In other experiments, large amounts of particles of UMWPE, HDPE, Ti alloy, CoCr alloy, zirkonium oxide or latex failed to induce bone resorption after intra-articular injection and after placement in the marrow cavity together with a PMMA implant (Van Der Vis et al 1997a). Other models, which have been interpreted to show particleinduced osteolysis (e.g., the dog hip prosthesis model by Dowd et al 1995), may in fact, have shown instability-induced osteolysis due to particles inhibiting porous ingrowth, so that initial stability was never achieved.…”