Benign Convulsions with Mild Rotavirus and Norovirus Gastroenteritis: Nationwide Data from the Health Insurance Review and Assessment Service in South Korea

Kim, Dong Hyun; Ha, Dong Jun; Lee, Yeong Seok; Chun, Min Jun; Kwon, Young Se

doi:10.3390/children8040263

Cited by 5 publications

(19 citation statements)

References 47 publications

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“…The ratio of NoV-associated CwG to NoV gastroenteritis and that of rotavirus-associated CwG to rotavirus gastroenteritis were different among studies [113,116]. One nationwide dataset from health insurance reviews and associated services in South Korea showed that the prevalence of rotavirusassociated CwG did not change (0.013-0.024%) but the annual prevalence of NoV-associated CwG is increasing by 1.790 times each year from 0.00001% [112,113]. However, these studies have limitations as they use diagnostic codes without compiling data directly from patient charts.…”

Section: Benign Convulsions With Mild Gastroenteritismentioning

confidence: 82%

“…CwG is characterized by afebrile convulsions within 5 days of acute viral gastroenteritis in previously healthy infants and children between the ages of 6 months and 3 years without electrolyte balance or abnormal blood sugar level or abnormal result of cerebrospinal fluid analysis. Several reports have broadened the range of definitions for children aged <6 years with CwG [103,104,[109][110][111][112][113][114]. Convulsions in CwG are mostly generalized, usually clustered, and last less than 5 min.…”

Section: Benign Convulsions With Mild Gastroenteritismentioning

confidence: 99%

Section: Benign Convulsions With Mild Gastroenteritismentioning

confidence: 99%

“…After rotavirus vaccination, some changes in epidemiology and clinical characteristics occurred in NoV-associated CwG [103,104,112,113,115]. The ratio of NoV-associated CwG to NoV gastroenteritis and that of rotavirus-associated CwG to rotavirus gastroenteritis were different among studies [113,116]. One nationwide dataset from health insurance reviews and associated services in South Korea showed that the prevalence of rotavirusassociated CwG did not change (0.013-0.024%) but the annual prevalence of NoV-associated CwG is increasing by 1.790 times each year from 0.00001% [112,113].…”

Section: Benign Convulsions With Mild Gastroenteritismentioning

confidence: 99%

See 3 more Smart Citations

Epidemiology, Clinical Features, and Unusual Complications of Norovirus Infection in Taiwan: What We Know after Rotavirus Vaccines

Lin

Hsu

et al. 2022

Pathogens

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Noroviruses (NoVs) are one of the emerging and rapidly spreading groups of pathogens threatening human health. A reduction in sporadic NoV infections was noted following the start of the COVID-19 pandemic, but the return of NoV gastroenteritis during the COVID-19 pandemic has been noted recently. Research in recent years has shown that different virus strains are associated with different clinical characteristics; moreover, there is a paucity of research into extraintestinal or unusual complications that may be associated with NoV. The genomic diversity of circulating NoVs is also complex and may vary significantly. Therefore, this short narrative review focuses on sharing the Taiwan experience of NoV infection including epidemiology, clinical features, and complications following suboptimal rotavirus immunization in Taiwan (after October 2006). We also highlight the unusual complications associated with NoV infections and the impacts of NoV infection during the COVID-19 pandemic in the literature for possible future research directions. To conclude, further research is needed to quantify the burden of NoV across the spectrum of disease severity in Taiwan. The evidence of the connection between NoV and the unusual complications is still lacking.

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Section: Benign Convulsions With Mild Gastroenteritismentioning

confidence: 82%

Section: Benign Convulsions With Mild Gastroenteritismentioning

confidence: 99%

Section: Benign Convulsions With Mild Gastroenteritismentioning

confidence: 99%

Section: Benign Convulsions With Mild Gastroenteritismentioning

confidence: 99%

See 2 more Smart Citations

Epidemiology, Clinical Features, and Unusual Complications of Norovirus Infection in Taiwan: What We Know after Rotavirus Vaccines

Lin

Hsu

et al. 2022

Pathogens

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show abstract

“…Since then, several reports have broadened the range of definitions for patients aged <6 years with CwG. [10][11][12][13][14][15][16] CwG is frequently reported in East Asian countries as well as in the United States and Europe. 17,18) After the introduction of rotavirus vaccines, some changes in epidemiology and clinical characteristics occurred in rotavirusassociated CwG (RaCwG) as well as norovirus-associated CwG (NaCwG).…”

Section: Introductionmentioning

confidence: 99%

Update on benign convulsions with mild gastroenteritis

Lee

Kwon

2022

Clin Exp Pediatr

Self Cite

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Benign convulsions with mild gastroenteritis (CwG) are characterized by afebrile convulsions associated with viral gastroenteritis in previously healthy infants and children. The main causative pathogens are rotavirus and norovirus. CwG occurs frequently in both East Asian and Western countries. The prevalence of CwG was reportedly not decreased by the introduction of rotavirus vaccines, and the prevalence of norovirus-associated CwG has been increasing annually. Convulsions in CwG are usually clustered, do not last longer than 5 minutes, and are mostly generalized. Laboratory diagnostics, electroencephalography (EEG), and imaging findings are usually normal. There is a probability of mild, transient abnormal findings on EEG or imaging limited to the acute disease phase. Although several reports have suggested that pathogens that affect the central nervous system through direct or indirect mechanisms could be related to the pathophysiology of CwG, its mechanism is not fully understood. Several antiepileptic drugs are effective during convulsions; however, long-term antiepileptic treatment is not required as CwG usually has a good prognosis.

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Norovirus-associated neurological manifestations: summarizing the evidence

Deb,

Mondal,

Lahiri

et al. 2023

J. Neurovirol.

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Norovirus, a positive-stranded RNA virus, is one of the leading causes of acute gastroenteritis among all age groups worldwide. The neurological manifestations of norovirus are underrecognized, but several wide-spectrum neurological manifestations have been reported among infected individuals in the last few years. Our objective was to summarize the features of norovirus-associated neurological disorders based on the available literature. We used the existing PRISMA consensus statement. Data were collected from PubMed, EMBASE, Web of Science, and Scopus databases up to Jan 30, 2023, using pre‐specified searching strategies. Twenty-one articles were selected for the qualitative synthesis. Among these, seven hundred and seventy-four patients with norovirus-associated neurological manifestations were reported. Most cases were seizure episodes, infection-induced encephalopathy, and immune-driven disorders. However, only a few studies have addressed the pathogenesis of norovirus-related neurological complications. The pathogenesis of these manifestations may be mediated by either neurotropism or aberrant immune-mediated injury, or both, depending on the affected system. Our review could help clinicians to recognize these neurological manifestations better and earlier while deepening the understanding of the pathogenesis of this viral infection.

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Benign Convulsions with Mild Rotavirus and Norovirus Gastroenteritis: Nationwide Data from the Health Insurance Review and Assessment Service in South Korea

Cited by 5 publications

References 47 publications

Epidemiology, Clinical Features, and Unusual Complications of Norovirus Infection in Taiwan: What We Know after Rotavirus Vaccines

Epidemiology, Clinical Features, and Unusual Complications of Norovirus Infection in Taiwan: What We Know after Rotavirus Vaccines

Update on benign convulsions with mild gastroenteritis

Norovirus-associated neurological manifestations: summarizing the evidence

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