Bentall Operation for Prosthetic Valve Endocarditis with Hereditary Hemorrhagic Telangiectasia

Morita, Hideki; Kimura, Naoyuki; Yasuda, Kôichi; Adachi, Koichi; Yamaguchi, Atsushi; Adachi, Hideo

doi:10.5761/atcs.cr.12.01933

Cited by 4 publications

(1 citation statement)

References 4 publications

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“…11 Entre los sitios extracerebrales se han descrito: endocarditis bacteriana, empiema, abscesos hepáticos y espondilodiscitis, siendo frecuentemente aislado Staphylococcus aureus como germen responsable. 13,14 Musso y colaboradores lograron identificar en su experiencia, únicamente 1 caso de espondilodiscitis, 13 debido a lo cual, el caso que se presenta puede considerarse particularmente inusual.…”

Section: Discussionunclassified

Síndrome Rendu Osler Weber asociado a Espondilodiscitis por Staphylococcus aureus

Carranza-Valverde

Padilla-Cuadra

Carballo-Madrigal

2020

AMC

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La telangiectasia hemorrágica hereditaria o síndrome de Rendu-Osler-Weber, es un desorden autonómico dominante, debido a mutaciones del gen de la endoglina o del gen de la cinasa análoga al receptor de activina. Dichaenfermedad se caracteriza por la presencia de telangiectasias en piel y mucosas, epistaxis recurrente y espontánea, además de malformaciones arteriovenosas en pulmones, cerebro y sistema gastrointestinal. Se ha reportado la asociación entre esta entidad e infecciones en diferentes sitios por Staphylococcus aureus. Los mecanismos de dicha predisposición incluyen la presencia de fístulas arteriovenosas y disfunción polimorfonuclear. Se reporta el caso de una paciente portadora de la enfermedad que asoció osteomielitis vertebral; requirió tratamiento antibiótico prolongado y cirugía de fusión e instrumentación de la columna vertebral a nivel torácico. Es necesario considerar este tipo de infecciones en pacientes con tal enfermedad, lo cual puede ayudar a la escogencia del tratamiento antibiótico y del manejo del paciente más expedito.

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Section: Discussionunclassified

Síndrome Rendu Osler Weber asociado a Espondilodiscitis por Staphylococcus aureus

Carranza-Valverde

Padilla-Cuadra

Carballo-Madrigal

2020

AMC

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Hereditary haemorrhagic telangiectasia type 1 complicated by recurrent deep-seated MSSA infections necessitating lifelong antibiotic suppression

Tracy,

Adereti,

Chu

et al. 2024

BMJ Case Rep

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Hereditary haemorrhagic telangiectasia (HHT) leads to arteriovenous malformations (AVM) that increase the risk of haemorrhage and cause right-left shunting bypassing the reticuloendothelial system increasing the risk for recurrent infections. A 60+ year old male patient with HHT type 1 (status post six pulmonary AVM coiled embolisations) with epistaxis presented with intractable back pain, methicillin-sensitiveStaphylococcus aureus(MSSA) bacteraemia and spinal MRI revealing spondylodiskitis and L4-L5 epidural phlegmon. He has an extensive history of deep-seated infections including two prior spinal infections, two joint infections and one muscular abscess—all with MSSA. The patient was treated with 6 weeks of intravenous nafcillin with symptom resolution. Infectious disease prescribed cefalexin 500 mg daily for suppression of infection recurrence considering his extensive deep-seated infection history and multiple risk factors. This case raises important questions about preventative antimicrobial management of high-risk patients with HHT, which is a grey area in current international HHT guidelines.

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Probiotics and infective endocarditis in patients with hereditary hemorrhagic telangiectasia: a clinical case and a review of the literature

et al. 2018

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BackgroundIn the last decades, probiotics have been widely used as food supplements because of their putative beneficial health effects. They are generally considered safe but rare reports of serious infections caused by bacteria included in the definition of probiotics raise concerns on their potential pathogenic role in patients with particular predisposing factors. Patients with hereditary hemorrhagic telangiectasia (HHT) are exposed to infections because of telangiectasias and arteriovenous malformations (AVMs). We describe what is, to our knowledge, the first case of infective endocarditis (IE) caused by Lactobacillus rhamnosus in a patient with HHT. A systematic review of the relevant medical literature is presented.Case presentationA patient with HHT and an aortic bioprosthesis was admitted because of prolonged fever not responding to antibiotics. The patient had a history of repeated serious infections with hospitalizations and prolonged use of antibiotics, and used to assume large amounts of different commercial products containing probiotics. Weeks before the onset of symptoms the patient had been treated with nasal packings and with surgical closure of a nasal bleeding site because of recurrent epistaxis. A diagnosis of IE of the aortic bioprosthesis was made. All blood coltures were positive for L. rhamnosus. The patients responded to a cycle of 6 weeks of amoxicillin/clavulanate plus gentamicin. A systematic review of IE linked to consumption of probiotics, and of infective endocarditis in patients with HHT was conducted. 10 cases of IE linked to probiotics consumption and 6 cases of IE in patients with HHT were found.ConclusionsConsumption of probiotics can pose a risk of serious infections in patients with particular predisposing factors. Patients with HHT can be considered at risk because of their predisposition to infections. Prophylaxis with antibiotics before nasal packings in patients with HHT can be considered.Electronic supplementary materialThe online version of this article (10.1186/s12879-018-2956-5) contains supplementary material, which is available to authorized users.

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Bentall Operation for Prosthetic Valve Endocarditis with Hereditary Hemorrhagic Telangiectasia

Cited by 4 publications

References 4 publications

Síndrome Rendu Osler Weber asociado a Espondilodiscitis por Staphylococcus aureus

Síndrome Rendu Osler Weber asociado a Espondilodiscitis por Staphylococcus aureus

Hereditary haemorrhagic telangiectasia type 1 complicated by recurrent deep-seated MSSA infections necessitating lifelong antibiotic suppression

Probiotics and infective endocarditis in patients with hereditary hemorrhagic telangiectasia: a clinical case and a review of the literature

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