Benzocaine anaphylaxis

Vu, Amy; Lockey, Richard F.

doi:10.1016/j.jaci.2006.04.035

Cited by 19 publications

(6 citation statements)

References 7 publications

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“…34 Practical observations about anaphylaxis included a reminder that accidental injection of a digit with epinephrine from an autoinjector may require therapy with warm soaks, topical nitroglycerin, or localized phentolamine injection; 35 that in an office-based allergy practice, 0.67% of injection immunotherapy treatments required treatment with epinephrine and 16% of these required more than 1 dose; 36 and that serum tryptase could sometimes be elevated for a prolonged period in idiopathic anaphylaxis. 37 Unique or rare causes of anaphylaxis were reported, including topical benzocaine, 38 the disinfectant solution ortho-phthalaldehyde, 39 and prostate-specific antigen in seminal plasma. 40 In regard to future therapy, a fast-disintegrating tablet to provide sublingual epinephrine was tested in a rabbit model and showed favorable pharmacokinetics compared with intramuscular injection.…”

Section: Anaphylaxismentioning

confidence: 99%

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects

Sicherer

Leung

2007

Journal of Allergy and Clinical Immunology

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This review highlights some of the research advances in anaphylaxis and hypersensitivity reactions to foods, drugs, and insects and in allergic skin disease that were reported primarily in the Journal in 2006. Advances in diagnosis include identification of food proteins to which IgE binding is associated with severe reactions; elucidation of diagnostic relationships of skin prick test wheal size with outcomes of egg, tree nut, and sesame allergy; evaluation of the diagnostic utility of atopy patch testing for food; and the observation that yellow jacket sting outcomes are influenced by species. Mechanistic observations include the following: heating of birch pollen-related foods disrupts IgE binding but not T-cell epitopes; a simple imbalance of T(H)1/T(H)2 response does not explain variations in clinical expression of peanut allergy; and elucidation of the role of dendritic cells in drug hypersensitivity. With regard to treatment, a rapidly disintegrating epinephrine tablet showed promise for sublingual treatment of anaphylaxis, RNA interference techniques showed promise in creating lower-allergenic foods, and anti-IL-5 showed promise for treatment of eosinophilic esophagitis. Progress in our understanding of the immunology and the etiology of skin barrier dysfunction in atopic dermatitis has also been made. These observations will likely contribute toward optimizing management of these common allergic disorders.

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Section: Anaphylaxismentioning

confidence: 99%

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects

Sicherer

Leung

2007

Journal of Allergy and Clinical Immunology

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“…11,21,24,25 Because ester local anesthetics may induce local anesthetic allergies and, at least in high doses, methemoglobinemia, it would be beneficial if an easy topical anesthetic technique using amide local anesthetics would be an option in Japan. 4,26,27 Conventionally, lidocaine had been thought to produce topical anesthesia at a concentration of 5% or more. 28 However, Nakamura et al 6 showed that a lower concentration of 2% could also be effective for topical anesthesia.…”

Section: Discussionmentioning

confidence: 99%

Effect of Topical Anesthesia Using an Adhesive Patch and Anesthetic Solution

Kishimoto

Matsuura

Kasahara

et al. 2017

Anesthesia Progress

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We analyzed trigeminal somatosensory evoked potentials (TSEP) to the alveolar mucosa to investigate the efficacy of an amide local anesthetic, 2% lidocaine hydrochloride with 12.5 lg/mL epinephrine (Lido treatment) as a topical anesthetic. Eighteen consenting healthy adult volunteers were enrolled. A volume of 0.06 mL of Lido, 0.06 g of 20% benzocaine, or 0.06 mL of physiological saline (control) was instilled onto a hemostatic adhesive patch, which was then applied to the alveolar mucosa at the maxillary right canine for 5 minutes. An electrical stimulus approximately 5 times that of the sensory threshold was applied using a surface stimulation electrode. The trigeminal somatosensory evoked potential was recorded immediately, 5 minutes, and 10 minutes after removal of the patch. Positive P125 and P310 peaks and negative N100 and N340 peaks were observed as a result of the electrical stimulation. A significant decrease in the percentage change in amplitude of N100-P125 was observed in the Lido treatment immediately, 5 minutes, and 10 minutes after patch removal. In the Lido treatment, trigeminal somatosensory evoked potential amplitude at N100-P125 decreased significantly, suggesting that topical anesthesia produced by an amide local anesthetic may have a topical anesthetic effect as potent as that produced by an ester local anesthetic.

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“…Allergic contact dermatitis caused by benzocaine was found in patients who used condoms containing benzocaine for ejaculation delay [ 24 ]. Vu and Lockey [ 25 ] reported anaphylactic shock after use of benzocaine as a local anesthetic during a cosmetic procedure. Thiurams are potent allergens, used mainly to accelerate vulcanization of various types of gum.…”

Section: Discussionmentioning

confidence: 99%

Analysis of skin patch test results and metalloproteinase-2 levels in a patient with contact dermatitis

Wojciechowska¹,

Czajkowski²,

Kowaliszyn³

et al. 2015

pdia

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IntroductionThe complex course of skin reactions that contact eczema involves is due in part to abnormalities of the extracellular matrix function. Proteins that degrade extracellular matrix components include metalloproteinases (MMP), which are divided into subcategories depending on the chemical structure and substrate specificity.AimTo analyse patch test results in contact dermatitis patients and to assess MMP-2 levels during skin lesion exacerbation and remission.Material and methodsFifty patients suffering from contact eczema were qualified to the study and 20 healthy volunteers as a control group. The study group patients had epidermal skin tests performed with the “European Standard” set. To assess the MMP-2 level in serum, venous blood was drawn, twice from study group patients – during contact dermatitis exacerbation and remission periods – and once from control group patients. Assessment of MMP-2 in serum was done with ELISA immunoassay. To verify the proposed hypotheses, parametric and nonparametric significance tests were used.ResultsHands were the most frequent location of contact dermatitis. Nickel (II) sulphate was the most frequent sensitizing substance. Mean MMP-2 levels were statistically higher in the study group both in contact dermatitis exacerbation and remission periods than in the control group. There was no statistically significant difference between MMP-2 levels and skin patch test results.ConclusionsNickel is one of the most allergenic contact allergens in patients with contact dermatitis. Metalloproteinase-2 is a good marker of contact dermatitis in various stages of the disease.

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Benzocaine anaphylaxis

Cited by 19 publications

References 7 publications

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects

Effect of Topical Anesthesia Using an Adhesive Patch and Anesthetic Solution

Analysis of skin patch test results and metalloproteinase-2 levels in a patient with contact dermatitis

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