Benzofuran derivatives and their anti-tubercular, anti-bacterial activities

Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer

“…Heterocyclic compounds in particular oxygen containing heterocycles represent an important class of compounds possessing interesting pharmacological and biological activities [21][22][23] . Benzofuran nucleus, as a key functional scaffold, represents a basic structure in a diversity of biologically active synthetic and natural products [24][25][26] , with broad range of desirable activities including; anti-Alzheimer's 27 , antibacterial 28 , anti-tubercular 29 , antioxidant 30 , anti-inflammatory 31 , as well as antitumor activities 32 . Benzofuran derivatives exert their antiproliferative activity with diversified mechanisms such as inhibition of tubulin polymerisation 33,34 , HIF-1 35 , Aurora B kinase 36 and VEGFR-2 activity 37 .…”

Development of 3-methyl/3-(morpholinomethyl)benzofuran derivatives as novel antitumor agents towards non-small cell lung cancer cells

“…Lung infections, headed by tuberculosis have been implicated as potentially contributing to lung cancer 35 . In this study, we decided to explore the potential anti-tubercular activity of target benzofuran derivatives 17 . The three most promising benzofuran-based derivatives herein reported (4b, 15a and 16a) were assessed for their potential anti-tubercular activity towards M. tuberculosis following the procedures of the Microplate Alamar Blue Assay 36 , and using INH as a reference anti-TB drug.…”

“…Benzofuran derivatives tagged with diverse pharmacophoric groups proved to possess multiple pharmacological activities for the past decades 9,10 . Among these pharmacological activities, benzofuran derivatives exhibit significant inhibitory carbonic anhydrase 11,12 , antioxidant 13 , anti-Alzheimer's 14 , anti-inflammatory 15 , antibacterial 15,16 , antitubercular 17 , as well as anticancer activities 18 . Benzofurans were reported to exert their antiproliferative activities through diverse mechanisms of cellular proliferation inhibition including apoptosis induction [19][20][21][22][23] and VEGFR-2 inhibitory action [24][25][26] .…”

Synthesis, structure and in vitro cytotoxicity testing of some 2-aroylbenzofuran-3-ols

“…For example, (+)-liphagal is a selective phosphoinositide-3-kinase -inhibitor (Marion et al, 2006), cyclopenta [b]benzofuran compounds possess antitumour and antiviral activities (Kim et al, 2006), while derivatives of egonol have antioxidant and anti-inflammatory activities (Timmers et al, 2015). Synthetic benzofuran derivatives are found to possess antitumour and anticancer (Shi et al, 2016;Marquès et al, 2016;Napió rkowska et al, 2019;Asadi et al, 2017), antimicrobial (Asadi et al, 2017;He et al, 2017;Xu et al, 2019) and antitubercular (Xu et al, 2019) activities. Some synthetic benzofuran derivatives have been investigated in the role of osteogenic (Marquè s et al, 2016;Kushwaha et al, 2018;Modukuri et al, 2017) or vasorelaxant (Hassan et al, 2014) agents.…”