Benzofuran Small Molecules as Potential Inhibitors of Human Protein Kinases. A Review

Abstract

Kinases are known to regulate the majority of human cellular processes such as communication, division, metabolism, survival and apoptosis therefore they can be promising targets in cancer diseases, viral infection and in other disorders. Small molecules acting as selective human protein kinase inhibitors are very attractive pharmacological targets. This review presents a number of examples of biologically active natural and synthetic benzo[b]furans and their derivatives, such as benzo[b]furan-2- and 3-ones, benzo[b]furan-2- and 3-carboxylic acids, as well as benzo[c]furans as potential inhibitors of various human protein kinases. The pathways of function and implication of the inhibitors in cancer and other diseases are discussed.

A novel benzofuran derivative, ACDB, induces apoptosis of human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress

“…Benzofuran appears structurally like natural products and functions as human protein kinase inhibitors [19]. Recently, benzofuran has been reported the role of antiproliferative activity in tumors especially against p53-independent malignant tumors [20].…”

Effect of Alloying on Magnetism and Electronic Structure of Gd(In1-xSnx)3System - ab initio Study

“…For each calculated structure the test of total energy convergence against the k mesh was performed to achieve the total energy accuracy of 0.1 mRy, sucient for analysis of magnetic ordering effects. The calculations were performed for three types of antiferromagnetic structure using the experimental values of lattice parameters taken from [4].…”

Development of 3-methyl/3-(morpholinomethyl)benzofuran derivatives as novel antitumor agents towards non-small cell lung cancer cells

“…Benzofuran derivatives tagged with diverse pharmacophoric groups proved to possess multiple pharmacological activities for the past decades 9,10 . Among these pharmacological activities, benzofuran derivatives exhibit significant inhibitory carbonic anhydrase 11,12 , antioxidant 13 , anti-Alzheimer's 14 , anti-inflammatory 15 , antibacterial 15,16 , antitubercular 17 , as well as anticancer activities 18 . Benzofurans were reported to exert their antiproliferative activities through diverse mechanisms of cellular proliferation inhibition including apoptosis induction [19][20][21][22][23] and VEGFR-2 inhibitory action [24][25][26] .…”