2023
DOI: 10.1002/cbdv.202301271
|View full text |Cite
|
Sign up to set email alerts
|

Benzothiazole‐Propanamide Linker Pyrrolidine (Morpholine) as Monoamine Oxidase‐B and Butyrylcholinesterase Inhibitors

Zhi‐Wen He,
B. S. Kai‐Yin Jiang,
Xin‐Hao Sun
et al.

Abstract: According to the fusion technique create effective multi‐target‐directed ligands, in this study, we designed and synthesized a series of benzo[d]thiazol‐2‐yl)‐3‐(pyrrolidin‐1‐yl) or 3‐(morpholino‐1‐yl)propanamide derivatives, and evaluated their inhibitory potency against MAOs, AChE, BuChE by in vitro enzyme effect assays. Based on activity results, we found that derivatives N‐(5‐methylbenzo[d]thiazol‐2‐yl)‐3‐(pyrrolidin‐1‐yl)propanamide (2c) and N‐(6‐bromo‐ benzo[d]thiazol‐2‐yl)‐3‐(pyrrolidin‐1‐yl)propanamide… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
(1 citation statement)
references
References 33 publications
(58 reference statements)
0
1
0
Order By: Relevance
“…Monoamine oxidase A (MAO-A) inhibition assay was performed using the MAO-A Inhibitor Screening Assay Kit (Abcam, Cambridge, United Kingdom) ( Supplementary Information S1 ) ( He et al, 2023 ). Briefly, 10 µL MO extract solution and kit-positive control (clorgyline) solution were added to a 96-well plate.…”
Section: Methodsmentioning
confidence: 99%
“…Monoamine oxidase A (MAO-A) inhibition assay was performed using the MAO-A Inhibitor Screening Assay Kit (Abcam, Cambridge, United Kingdom) ( Supplementary Information S1 ) ( He et al, 2023 ). Briefly, 10 µL MO extract solution and kit-positive control (clorgyline) solution were added to a 96-well plate.…”
Section: Methodsmentioning
confidence: 99%