�ber das fetale Gef��system der reifen menschlichen Placenta

Nikolov, Sp. D.; Schiebler, T. H.

doi:10.1007/bf00306590

Cited by 43 publications

(13 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is evident from the current results that the sinusoidal dilatation cannot be regarded as dilated venous limbs of the capillary loop which allow for a retarded venous back flow as has been suggested by Nikolov and Schiebler (1973). The localization of the sinusoids near to the villous tips may support the conclusion of Arts (1961) that the sinusoids locally decelerate the blood flow, thus providing ample opportunity for feto-maternal exchange.…”

Section: Functional Relevance Of Sinusoidssupporting

confidence: 49%

See 1 more Smart Citation

Three-Dimensional Representation of the Fetal Vessel System in the Human Placenta

Kaufmann

Luckhardt

Leiser

1988

Placental Vascularization and Blood Flow

View full text Add to dashboard Cite

Section: Functional Relevance Of Sinusoidssupporting

confidence: 49%

“…From 0 to 380 spiral turns have been reported (Boyd and Hamilton, 1970). It should be noted that except for the first centimeter of the cord near the umbilicus, the following placental vessels are free of nerves (Lachenmayer, 1971, Nikolov andSchiebler, 1973).…”

Section: Umbilical Vessels and Vessels Of The Chorionic Platementioning

confidence: 97%

Three-Dimensional Representation of the Fetal Vessel System in the Human Placenta

Kaufmann

Luckhardt

Leiser

1988

Placental Vascularization and Blood Flow

View full text Add to dashboard Cite

“…Nikolov and Schiebler (1973) reported for foetal blood vessels of the term placenta, that elastic fibres were present only in umbilical veins but absent in placental vessels. In contrast, Hofman (1967) and Boyd and Hamilton (1970) described elastic fibres in placental blood vessels.…”

Section: Discussionmentioning

confidence: 93%

Elastic fibres are an essential component of human placental stem villous stroma and an integrated part of the perivascular contractile sheath

Graf

Neudeck

Gossrau

et al. 1995

Cell and Tissue Research

View full text Add to dashboard Cite

The stroma of human placental stem villi is believed to consist only of reticular and collagen fibres. In the present study we were able to show for the first time by light (orcein staining) and electron microscopy large amounts of elastic fibres in the stem villous stroma. Electron microscopically, homogeneous elastin was found alone or in association with microfibrils. In addition, microfibrils were observed forming long bands. These three structures, generally known to form elastic connective tissue, were seen in close connection with placental extravascular smooth muscle cells, which belong to the perivascular contractile sheath (PVCS) of stem villi. Elastin was associated with these smooth muscle cells and connected to collagen fibres via microfibrils. Collagen fibres were additionally interconnected by spike-like structures. Extravascular smooth muscle cells revealed numerous adhesion plaques which occupied conspicuously long cytoplasmic faces of the plasma membrane. In cryostat sections, immunoreactivity of talin, an attachment protein of adhesion plaques linking intracellular alpha-actin filaments with extracellular fibronectin, was detected in extravascular and vascular (media) smooth muscle cells. The arrangement of placental extravascular smooth muscle cells, elastic and collagen fibres suggests a functional myofibroelastic unit within the PVCS, which surrounds the large foetal blood vessels possibly contributing to elasticity and supporting tensile and/or contracting forces within the stem villi.

show abstract

“…The existence of elastic tissue fibres in the placental stroma and fetal placental blood vessel tree has been controversially discussed during the last century (Henneberg 1902;Hofman 1967;Boyd and Hamilton 1970;Nikolov and Schiebler 1973;Baccarani-Contri et al 1989). In a series of studies, we have demonstrated that elastic tissue fibres are an essential component of both, perivascular contractile sheath and fetal blood vessels within trunci and rami chorii in human placental stem villi and umbilical cord stroma and blood vessels (Graf et al 1996(Graf et al , 1998Junek et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Decrease of elastic tissue fibres in stem villus blood vessels of the human placenta during IUGR and IUGR with concomitant pre-eclampsia

Wilhelm

Mansmann

Neudeck

et al. 2002

Anatomy and Embryology

View full text Add to dashboard Cite

In a recent study we described an increase of elastic tissue fibres in blood vessel walls of placental stem villi during pre-eclampsia when compared to uncomplicated pregnancies. Furthermore, the thickness of these blood vessel walls was enhanced in pre-eclampsia. Since it is known that elastic tissue fibres increase in systemic hypertension, it may be assumed that the enhancement of elastic tissue fibres in placental stem villi during pre-eclampsia may be induced by the hypertension. To get further insight into this assumption, we examined the amount of elastic tissue fibres in stem villus blood vessels of placentae of pregnancies complicated by intrauterine growth retardation (isolated IUGR, fourteen cases), a disease without hypertension of the mother and such with pre-eclampsia and concomitant IUGR (IUGR+PE, nine cases). Each study group was compared with uncomplicated pregnancies (twenty-six cases). Unfixed cryostat serial sections were processed for conventional orcein staining and for the demonstration of alpha-actin-immunoreactivity. The intensity of orcein staining of stem villus blood vessel walls was evaluated by a semiquantitative score method. Significant lower intensities of orcein staining were calculated for blood vessel walls of placentae of isolated IUGR (P=0.0007) and IUGR+PE (P=0.0039) when compared to uncomplicated pregnancies each. Additionally, the blood vessel wall thickness of stem villi of isolated IUGR (P=0.0081) and IUGR+PE (P=0.0007) was significantly reduced. In comparison to the above mentioned investigation, our results show that, in contrast to isolated pre-eclampsia, elastic tissue fibres are decreased during pregnancies complicated by IUGR, independently of the occurrence of concomitant pre-eclampsia when compared to uncomplicated pregnancies. From our studies it may be considered that the increase of elastic tissue fibres in placentae of patients with isolated pre-eclampsia may be induced by systemic hypertension. Furthermore, our study underline arguments that IUGR may be an independent disease of the fetus.

show abstract

�ber das fetale Gef��system der reifen menschlichen Placenta

Cited by 43 publications

References 33 publications

Three-Dimensional Representation of the Fetal Vessel System in the Human Placenta

Three-Dimensional Representation of the Fetal Vessel System in the Human Placenta

Elastic fibres are an essential component of human placental stem villous stroma and an integrated part of the perivascular contractile sheath

Decrease of elastic tissue fibres in stem villus blood vessels of the human placenta during IUGR and IUGR with concomitant pre-eclampsia

Contact Info

Product

Resources

About