�ber den Einflu� verschiedener kardiotonischer Verbindungen auf die Transport-ATPase in der Zellmembran des Herzmuskels

Repke, K.; Portius, H. J.

doi:10.1007/bf00260048

Cited by 17 publications

(3 citation statements)

References 7 publications

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“…From clinical experience it is well known that the enteral absorption of cardiac glycosides shows large differences for the various drugs : thus, whereas digitoxin is absorbed completely, the absorption of ouabain is particularly uncertain and in most cases negligible. These clinical observations confirmed early animal studies with the Hatcher procedure (for reviews see Rothlin & Bircher, 1954;Wright, 1960). In recent experiments (Lahrtz, Sattler & Zwieten, 1968) it was shown that in the cat, intraduodenally applied [3H]labelled digitoxin reached a much higher serum level than did [3H]digoxin by the same route.…”

Section: Fate Of [3h]labelled Glycosides In Animals and Mansupporting

confidence: 72%

“…The distribution of radioactively labelled cardiac glycosides between various organs has been investigated in a number of animal species (Repke, 1958 ;Gonzalez & Layne, 1960;Bretschneider, Doering & others, 1962;Dutta, Marks & Smith, 1963;Marks, Dutta & others, 1964;Fauconnet &Widmer, 1965;Liillmann & Schaum, 1968) In most of these studies no particular affinity of the cardiac glycosides for heart muscle tissue could be demonstrated. No particular accumulation in heart muscle tissue was observed, since the highest concentration was found in the excretion organs like liver, colon and kidneys.…”

Section: Fate Of [3h]labelled Glycosides In Animals and Manmentioning

confidence: 99%

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The kinetic behaviour of cardiac glycosides in vivo, measured by isotope techniques

Lüllmann

Zwieten

1969

Journal of Pharmacy and Pharmacology

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Section: Fate Of [3h]labelled Glycosides In Animals and Mansupporting

confidence: 72%

Section: Fate Of [3h]labelled Glycosides In Animals and Manmentioning

confidence: 99%

The kinetic behaviour of cardiac glycosides in vivo, measured by isotope techniques

Lüllmann

Zwieten

1969

Journal of Pharmacy and Pharmacology

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“…It is well known that the Na, K-activated ATP-hydrolyzing enzyme system (Na, K-ATPase) is inhibited by sulfhydryl blocking reagents (AUDITORE and MURRAY, 1962;GLYNN, 1963;LANDON and NORRIS, 1963;REPKE and PORTIUS, 1963). One of the sulfhydryl blocking reagents i.e., NEM, which was used in the present study, also inhibits the activity of Na, K-ATPase in brain tissues (SKOU, 1963 ;SKOU and HILBERG, 1965).…”

mentioning

confidence: 81%

Different Effects of N-Ethylmaleimide on the Tension Components of Bullfrog Atrium

Aomine

Abe

1978

Jpn.J.Physiol

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The effects of N-ethylmaleimide (NEM) on the tension components of bullfrog atrium were studied under voltage clamp conditions using the double sucrose gap technique. NEM at a dilution of 10-3 M inhibited the ICa-independent tonic tension elicited by large and long depolarizing pulses (140 mV, 2 sec) time-dependently, whereas the drug produced an initial transient increase and a later decrease of the ICa-dependent phasic tension elicited by small and short depolarizing pulses (60 mV, 100 msec). The effect of NEM was facilitated when the atrial muscles were exposed to a solution having either a reduced Na or an increased Ca concentration. In the presence of Mn ions, 10-3 M NEM did not evidently inhibit tonic tension, and it led to a slight transient increase in phasic tension. NEM at 10-3 M, which is known to inhibit sarcolemmal Na, K-ATPase, enhanced both the phasic tension and the tonic tension in the presence of ouabain and when perfused with K-free solution. Even under these conditions 10-3 M NEM caused an initial transient decrease of ICa-independent tonic tension. This suggests that NEM has a different action on the atrial muscle from those of cardiac glycosides such as ouabain.

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Digitalisforschung in Berlin‐Buch – Rückblick und Ausblick

et al. 1995

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Der Arzt William Withering führte 1785 mit seinem Buch „An Account of the Foxglove and some of its Medical Uses”︁ Präparate aus Digitalisblättern in die Therapie der Wassersucht (des Herzversagens) ein und erklärte: „The following remarks consist partially of matter of fact, and partially of opinion. The former will be permanent; the latter must vary with the detection of error, or the improvement of knowledge. I hazard them with diffidence, and hope they will be examined with candour.”︁ Diese Bemerkungen sind hier vom Seniorautor angeführt, da er die Schwierigkeit sieht, einen ausgewogenen Bericht über sein lebenslanges Forschungsprojekt zur Digitalis‐Weiterentwicklung zu bieten. Seine Entscheidung, sich der Digitalisforschung zu widmen, entstand am Krankenbett, an dem er als Arzt die furchtbaren Endstadien des Herzversagens erlebte, in denen für die Kranken keine wirkliche Hilfe mehr möglich ist. Unglücklicherweise paßte dieses Vorhaben nicht in das vom Wissenschaftsministerium der DDR dekretierte Forschungsprogramm, so daß er das Digitalisprojekt zugunsten von Biomembran‐Untersuchungen einstellen sollte. Glücklicherweise entging er dem Verdikt durch Etikettierung der digitalisartig wirkenden Steroide als chemische Sonden für die Zellmembran‐lokalisierte Na+/K+ ‐transportierende ATPase, die er gerade als den Digitalisrezeptor erkannt hatte. Über die Arbeit der Autoren wird hier erstmals im Zusammenhang berichtet. Ziel des Überblicks ist, die Forschung für die Lösung einer großen Aufgabe zu fördern: die Entwicklung von Steroidwirkstoffen zur Verhinderung und Heilung der Herzinsuffizienz.

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�ber den Einflu� verschiedener kardiotonischer Verbindungen auf die Transport-ATPase in der Zellmembran des Herzmuskels

Cited by 17 publications

References 7 publications

The kinetic behaviour of cardiac glycosides in vivo, measured by isotope techniques

The kinetic behaviour of cardiac glycosides in vivo, measured by isotope techniques

Different Effects of N-Ethylmaleimide on the Tension Components of Bullfrog Atrium

Digitalisforschung in Berlin‐Buch – Rückblick und Ausblick

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