Berbamine Analogs Exhibit Differential Protective Effects From Aminoglycoside-Induced Hair Cell Death

Hudson, Alexandria M.; Lockard, Gavin; Namjoshi, Ojas A.; Wilson, Joseph W.; Kindt, Katie S.; Blough, Bruce E.; Coffin, Allison B.

doi:10.3389/fncel.2020.00234

Cited by 9 publications

(10 citation statements)

References 60 publications

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“…In zebrafish, it has been shown that treatment with quinoline ring derivatives such as amsacrine, quinine, and mefloquine protects against aminoglycoside-induced hair-cell death by blocking uptake (Ou et al, 2012). Analogs of the quinoline ring derivative berbamine have also recently been shown to block uptake of aminoglycosides into hair cells; however, the degree of uptake block did not correlate with the magnitude of hair-cell protection from aminoglycosides, suggesting a second uptake-independent mechanism (Kruger et al, 2016;Hudson et al, 2020). Quinoline ring derivatives have been shown to have antioxidant properties in other systems (Detsi et al, 2007;Naik et al, 2009;Ghinet et al, 2012).…”

Section: Mitochondrial Ros Production and Antioxidant Protection Agai...mentioning

confidence: 99%

Using the Zebrafish Lateral Line to Understand the Roles of Mitochondria in Sensorineural Hearing Loss

Holmgren

Sheets

2021

Front. Cell Dev. Biol.

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Hair cells are the mechanosensory receptors of the inner ear and can be damaged by noise, aging, and ototoxic drugs. This damage often results in permanent sensorineural hearing loss. Hair cells have high energy demands and rely on mitochondria to produce ATP as well as contribute to intracellular calcium homeostasis. In addition to generating ATP, mitochondria produce reactive oxygen species, which can lead to oxidative stress, and regulate cell death pathways. Zebrafish lateral-line hair cells are structurally and functionally analogous to cochlear hair cells but are optically and pharmacologically accessible within an intact specimen, making the zebrafish a good model in which to study hair-cell mitochondrial activity. Moreover, the ease of genetic manipulation of zebrafish embryos allows for the study of mutations implicated in human deafness, as well as the generation of transgenic models to visualize mitochondrial calcium transients and mitochondrial activity in live organisms. Studies of the zebrafish lateral line have shown that variations in mitochondrial activity can predict hair-cell susceptibility to damage by aminoglycosides or noise exposure. In addition, antioxidants have been shown to protect against noise trauma and ototoxic drug–induced hair-cell death. In this review, we discuss the tools and findings of recent investigations into zebrafish hair-cell mitochondria and their involvement in cellular processes, both under homeostatic conditions and in response to noise or ototoxic drugs. The zebrafish lateral line is a valuable model in which to study the roles of mitochondria in hair-cell pathologies and to develop therapeutic strategies to prevent sensorineural hearing loss in humans.

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Section: Mitochondrial Ros Production and Antioxidant Protection Agai...mentioning

confidence: 99%

Using the Zebrafish Lateral Line to Understand the Roles of Mitochondria in Sensorineural Hearing Loss

Holmgren

Sheets

2021

Front. Cell Dev. Biol.

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“…Male C57/BL6 mice (8 weeks old, 20-25 g body weight) were provided by the Laboratory Animal Center at the Air Force Medical University and housed in a controlled environment (22)(23)(24)(25)…”

Section: Animalsmentioning

confidence: 99%

“…BA derivatives can improve cell proliferation of ROS and target calcium/calmodulin‐dependent death protein kinase II. Therefore, BA may play a potential protective role in antitumor and cardiovascular protection 22–25 . Previous studies have shown that BA prevents cardiomyocyte death and injury by inhibiting mitochondrial oxidative stress and the inflammatory response 26 .…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, BA may play a potential protective role in antitumor and cardiovascular protection. 22 , 23 , 24 , 25 Previous studies have shown that BA prevents cardiomyocyte death and injury by inhibiting mitochondrial oxidative stress and the inflammatory response. 26 Additionally, Sharma et al indicated that the protective effects of the preoperative application of BA are related to the AMPK activation/regulation of the mTOR/SREBP‐1c axis and the Nrf2/ antioxidant response element pathway to allay lipid accumulation and oxidative stress in steatotic HepG2 cells.…”

Section: Introductionmentioning

confidence: 99%

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Effects of berbamine against myocardial ischemia/reperfusion injury: Activation of the 5' adenosinemonophosphate‐activatedprotein kinase/nuclear factor erythroid2‐relatedfactor pathway and changes in the mitochondrial state

Liu

Zhai

et al. 2022

BioFactors

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This study was designed to investigate whether berbamine (BA)‐induced cardioprotective effects were related to 5′ adenosine monophosphate‐activated protein kinase (AMPK)/nuclear factor erythroid 2‐related factor (Nrf2) signaling and changes in the mitochondria in myocardial ischemia/reperfusion (I/R) injury. C57/BL6 mice were exposed to BA (10 mg/kg/d), with or without administration of the AMPK specific inhibitor compound C (5 mg/kg/d) or the Nrf2 specific inhibitor ML‐385 (30 mg/kg/d), and then subjected to a myocardial I/R operation. As expected, BA significantly improved post‐ischemic cardiac function, reduced infarct size and apoptotic cell death, decreased oxidative stress, and improved the mitochondrial state. Furthermore, BA markedly increased AMPK activation, Nrf2 nuclear translocation, and the levels of NAD(P)H quinone dehydrogenase and heme oxygenase‐1. Nevertheless, these BA‐induced changes were abrogated by compound C. In addition, ML‐385 also canceled the cardioprotective effects of BA but had little effect on AMPK activation. Our results demonstrate that BA alleviates myocardial I/R injury and the mitochondrial state by inhibiting apoptosis and oxidative stress via the AMPK/Nrf2 signaling pathway.

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“…39 Berbamine analogues protect against aminoglycoside-induced hair cell death in distinct ways. 40 Berbamine shields the heart from isoproterenol-induced myocardial infarction in rats via regulating the expression of eNOS and iNOS. 41 Through autophagy regulation, Berbamine post conditioning shields the myocardium from ischemia/reperfusion injury.…”

Section: Berbamine In Cancermentioning

confidence: 99%

Berbamine application beyond cancer

Soni¹

2021

Int J Basic Clin Pharmacol

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The main purpose of this review was to ascertain the clinical application and future non oncological uses of Berbaminebamine (BERBAMINE). Berbaminebamine, as a STAT3 (signal transducer and activator of transcription) inhibitor, antioxidant, anti-inflammatory and modulator of many signalling pathways, should be investigated in autoimmune diseases. Berbaminebamine has been found to have pharmacological activity in the following cancers: breast cancer, lung cancer, prostate cancer, pancreatic cancer, ovarian cancer, glioblastoma, colon cancer, bladder cancer, chronic myeloid leukemia, hepatocellular carcinoma, triple negative breast cancer and osteosarcoma. Ischemic reperfusion injury, melanoma, COVID-19 and allergy diseases are among the conditions for which it is beneficial. It may aid in the treatment of obesity, metabolic syndrome, inflammatory syndrome, sepsis, COVID-19, dengue fever, Nipah virus infection, influenza, solid tumors, lymphoma, cancer, hematological malignancies, skin inflammatory disorder and atopic dermatitis. BERBAMINE can be used as versatile molecule in alcoholic liver disease, diabetic nephropathy and antiviral, anti-inflammatory.

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Berbamine Analogs Exhibit Differential Protective Effects From Aminoglycoside-Induced Hair Cell Death

Cited by 9 publications

References 60 publications

Using the Zebrafish Lateral Line to Understand the Roles of Mitochondria in Sensorineural Hearing Loss

Using the Zebrafish Lateral Line to Understand the Roles of Mitochondria in Sensorineural Hearing Loss

Effects of berbamine against myocardial ischemia/reperfusion injury: Activation of the 5' adenosinemonophosphate‐activatedprotein kinase/nuclear factor erythroid2‐relatedfactor pathway and changes in the mitochondrial state

Berbamine application beyond cancer

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