Berberine and lycopene as alternative or add-on therapy to metformin and statins, a review

Hedayati, Narges; Oskouei, Zahra; Tabeshpour, Jamshid; Naeini, Mehri Bemani

doi:10.1016/j.ejphar.2021.174590

Cited by 10 publications

(7 citation statements)

References 119 publications

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“…Lycopene is a natural substance that may be used in high doses as a dietary supplement without causing harm to human health or physiology [10][11][12]. In accordance with these findings, lycopene has gotten a lot of interest as a possible nutraceutical for disease prevention and therapy, notably for improving vascular function and lowering blood pressure [13][14][15]. Biological and biomedical researchers are becoming increasingly interested in the expanding body of evidence indicating lycopene's disease-preventive properties.…”

Section: Introductionmentioning

confidence: 91%

Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases

et al. 2022

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Lycopene is a bioactive red pigment found in plants, especially in red fruits and vegetables, including tomato, pink guava, papaya, pink grapefruit, and watermelon. Several research reports have advocated its positive impact on human health and physiology. For humans, lycopene is an essential substance obtained from dietary sources to fulfil the body requirements. The production of reactive oxygen species (ROS) causing oxidative stress and downstream complications include one of the major health concerns worldwide. In recent years, oxidative stress and its counter strategies have attracted biomedical research in order to manage the emerging health issues. Lycopene has been reported to directly interact with ROS, which can help to prevent chronic diseases, including diabetes and neurodegenerative and cardiovascular diseases. In this context, the present review article was written to provide an accumulative account of protective and ameliorative effects of lycopene on coronary artery disease (CAD) and hypertension, which are the leading causes of death worldwide. Lycopene is a potent antioxidant that fights ROS and, subsequently, complications. It reduces blood pressure via inhibiting the angiotensin-converting enzyme and regulating nitrous oxide bioavailability. It plays an important role in lowering of LDL (low-density lipoproteins) and improving HDL (high-density lipoproteins) levels to minimize atherosclerosis, which protects the onset of coronary artery disease and hypertension. Various studies have advocated that lycopene exhibited a combating competence in the treatment of these diseases. Owing to all the antioxidant, anti-diabetic, and anti-hypertensive properties, lycopene provides a potential nutraceutical with a protective and curing ability against coronary artery disease and hypertension.

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Section: Introductionmentioning

confidence: 91%

Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases

et al. 2022

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“…Tablet Pentoxifylline (400 mg), thrice a day, wherein two brands were prescribed such as Trental (₹30.45) and Kinetal (₹26.52) and which had total costs of ₹822.15 and ₹716.04 for 60 days duration respectively. In the study, statin was prescribed along with combination regimen for prophylactic purpose in PVD patients, [22] and the cost was ₹1227 for 30 days. It represented the better disease control in patients with cost effectiveness.…”

Section: Fig 1 Patients Having Types Of Blockages At Different Sites ...mentioning

confidence: 99%

A Combined Treatment Effect of Cilostazol and Pentoxifylline in the Treatment of Peripheral Vascular Disease

Suthar

Shah²,

Ranjan

2022

AJMAH

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Background: (50 mg BD) and pentoxifylline (400 mg TDS) therapy in patients with PVD. Additionally, the adverse effects and economic burden of the combination was taken in to account. Methodology: An Observational antegrade study was done among 100 patients. A Patient with PVD visited to OPD of the vascular department was enrolled in the study. Data was collected as per the Case Record Form. Results: The mean age was found to be 58.4 ± 11.3 years of total 100 patients. An improvement in a Doppler testing (follow-up at the time interval after 1 month, 3 months and 6 months) and increased in peak systolic velocity in distal vessels as well as collaterals were observed in all patients. The PVD was prevalent in 50 to 60 years of age groups and hypertension and smoking were the most common risk factors present in PVD patients. There was more than 70% increase in walking distance after 24 weeks of treatment. Headache 24 (36.4%) and Dizziness 9 (13.6%) were observed as common side effect of therapy. The total cost of the combination therapy was affordable with improved quality of life. Conclusion: The combination treatment showed symptomatic improvement in peripheral vascular disease in the study. The peak systolic velocity gradually increased in the distal vessel and the combination was found to be cost-effective.

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“…Lycopene treatment is given either in single doses or in combination with other therapies such as metformin and statins. The results showed that lycopene is very beneficial for diabetic patients who are intolerant to statins (13). The combination of metformin with low doses of lycopene can reduce fasting blood glucose levels after two weeks of intervention (14), while high doses of 45 mg/kg can reduce blood glucose by 50%, and the results are the same as with single or combined doses of metformin and lycopene (15).…”

Section: Introductionmentioning

confidence: 99%

Lycopene Improves the Metformin Effects on Blood Glucose and Neutrophil Counts in Type 2 Diabetic Rats

Sianturi

Susilaningsih

Nugroho

et al. 2023

IJMLST

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In patients with type 2 diabetes mellitus (T2DM), both innate and acquired immunity are weakened by hyperglycemia. Lycopene is one of the hydrocarbon carotenoids that has been widely studied for its powerful antioxidant and anti-inflammatory properties, furthermore act as hypoglycemic and immunomodulator. Herein, we investigated the effect of lycopene and metformin combination on fasting blood glucose (FBG) and neutrophil counts. The rats were divided randomly into six groups, each containing five rats. Group 1 consisted of normal rats (N) and group 2, T2DM (DM) rats, which were administered 0.5 mL of coconut oil; group 3 T2DM rats were administered 250 mg/kg of metformin in 0.5 mL of coconut oil; groups 4,5 and 6 rats were administered a combination of metformin 250 mg/kg with 10 mg/kg (DML-10), 20 mg/kg (DML-20) and 40 mg/kg (DML-40) of lycopene in 0.5 mL of coconut oil, respectively. Treatment was administered every day for 28 days. A model of T2DM rats was induced by a high-fat diet for two weeks combined with streptozotocin–nicotinamide. Data were analyzed with a one-way ANOVA test followed by the least significant difference (LSD) test. There were significant differences in FBG levels and the number of neutrophils in all groups. Lycopene combined with metformin had lower FBG concentrations and higher neutrophil counts compared to metformin monotherapy (p<0.001), and these observations were dose-dependent. Lycopene combined with metformin can improve blood glucose and neutrophil counts in rats with diabetes. The highest effect was observed in combination with lycopene at a dose of 40 mg/kg and metformin at a dose of 250 mg/kg.

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Berberine and lycopene as alternative or add-on therapy to metformin and statins, a review

Cited by 10 publications

References 119 publications

Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases

Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases

A Combined Treatment Effect of Cilostazol and Pentoxifylline in the Treatment of Peripheral Vascular Disease

Lycopene Improves the Metformin Effects on Blood Glucose and Neutrophil Counts in Type 2 Diabetic Rats

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