Berberine as a potential agent for breast cancer therapy

Zhong, Xiao-Dan; Chen, Lijuan; Xu, Xin-Yang; Liu, Yanjun; Fan, Tao; Zhu, Minghui; Li, Changyun; Zhao, Dan; Yang, Guan–Jun; Chen, Jiong

doi:10.3389/fonc.2022.993775

Cited by 35 publications

(17 citation statements)

References 143 publications

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“…Berberine is a pentacyclic isoquinoline alkaloid compound isolated from Berberis genus plants. The broad pharmacological application of berberine includes anticancer, antidiabetic, anti-obesity, and cardioprotective effects ( Zhong et al, 2022 ). This compound interacts with specific receptors, ligands, and biological enzymes leading to anti-inflammatory and antioxidant activities ( Song et al, 2020 ).…”

Section: Targeting Lncrnas With Natural Products For Potential Crc Tr...mentioning

confidence: 99%

Targeting lncRNAs of colorectal cancers with natural products

Sung

Hong

2023

Front. Pharmacol.

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Non-coding RNA (ncRNA) is one of the functional classes of RNA that has a regulatory role in various cellular processes, such as modulation of disease onset, progression, and prognosis. ncRNAs, such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have been actively studied in recent years. The change in ncRNA levels is being actively studied in numerous human diseases, especially auto-immune disorders and cancers; however, targeting and regulating ncRNA with natural products to cure cancer has not been fully established. Recently many groups reported the relationship between ncRNA and natural products showing promising effects to serve as additional therapeutic approaches to cure cancers. This mini-review summarizes the aspects of lncRNAs related to cancer biology focusing on colorectal cancers that natural products can target.

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Section: Targeting Lncrnas With Natural Products For Potential Crc Tr...mentioning

confidence: 99%

Targeting lncRNAs of colorectal cancers with natural products

Sung

Hong

2023

Front. Pharmacol.

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“…BBR reduced the phosphorylation of the Rb protein, preventing transcriptional E2F activator separation from Rb and inhibiting the G1 to S phase transition (Wu et al, 2015). BBR induce the upregulation of p21 and p27 proteins to arrest the cell cycle (Zhong et al, 2022). BBR affects cell cycle progression to limit cancer cell growth Figure 1.…”

Section: Effect Of Bbr On Cell Cycle Regulationmentioning

confidence: 99%

Current understanding and future prospects on Berberine for anticancer therapy

Goel

2023

Chem Biol Drug Des

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Berberine (BBR) is a potential plant metabolite and has remarkable anticancer properties. Many kinds of research are being focused on the cytotoxic activity of berberine in in vitro and in vivo studies. A variety of molecular targets which lead to the anticancer effect of berberine ranges from p‐53 activation, Cyclin B expression for arresting cell cycles; protein kinase B (AKT), MAP kinase and IKB kinase for antiproliferative activity; effect on beclin‐1 involved in autophagy; reduced expression of MMP‐9 and MMP‐2 for the inhibition of invasion and metastasis etc. Berberine also interferes with transcription factor‐1 (AP‐1) activity responsible for the expression of oncogenes and neoplastic transformation of the cell. It also leads to the inhibition of various enzymes which are directly or indirectly involved in carcinogenesis like N acetyl transferase, Cyclo‐oxygenase‐2, Telomerase and Topoisomerase. In addition to these actions, Berberine plays a role in, the regulation of reactive oxygen species and inflammatory cytokines in preventing cancer formation. Berberine anticancer properties are demonstrated due to the interaction of berberine with micro‐RNA. The summarized information presented in this review article may help and lead the researchers, scientists/industry persons to use berberine as a promising candidate against cancer.

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“…Therefore, there is a need to discover and develop alternatives that work through multi-targets of cancer cells and used as a single or co-therapeutic agent with other drugs to treat cancers. In this regard, BBR has arisen from the traditional Chinese medicine [68]. BBR is a multi-target drug and has been proven effective in treating many cancers and inflammatory diseases.…”

Section: Effect Of Berberine On Apoptosis and Necrosis Of Transformed...mentioning

confidence: 99%

“…It also binds directly to several proteins and DNA sequences to exert its anticancer activities, such as salt-inducible kinase 3 (SIK3) [69], a single transmembrane cell surface protein ephrin-B2 [70], histone lysine demethylase 1 (LSD1) [71], DNA, TATA box and ply(A) tails [72][73][74], microRNA-214-3p and secretin [75][76][77]. BBR suppresses proliferation and migration of breast cancer cells through ZO-1 mediated Wnt/β-catenin signaling pathway, induces cell cycle arrest through upregulating p21 and p27, sensitizes chemical agents and overcomes drug resistance via activating AMPLK signaling, and inhibits TPA-induced PKC-α signaling in breast cancer cells [68]. In MCF-7/DOX Fluc cells, BBR reverses multi-drug resistance by inhibiting the efflux function of ATP-binding cassette transporters and downregulating their expression [78].…”

Section: Effect Of Berberine On Apoptosis and Necrosis Of Transformed...mentioning

confidence: 99%

Unravelling the Effects of Berberine on Metabolic Activity, Apoptosis and Proliferation of Transformed Cells

Alam¹,

Kulka²,

Wang³

2023

Preprint

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Berberine (BBR) is an isoquinoline that inhibits the proliferation of transformed cells in vitro, but due to its poor solubility and bioavailability, it has only moderate therapeutic potential in vivo. Increasing evidence indicates that BBR specifically targets several metabolic, signaling and gene transcription events in transformed cells, altering their progression through the cell cycle and decreasing their metabolic rate and proliferation. In order to further develop BBR as a therapeutic, its mode of cellular internalization and localization within the cell needs to be further examined. BBR’s molecular targets and interactions with kinases, transcription factors and some enzymes are discussed in an attempt to better understand BBR’s role in these important pathways and how they may lead to changes in metabolism. Lastly, this review examines some of the benefits and challenges of using BBR as an inhibitor in cancer cell proliferation in breast cancer and glioblastoma, as two examples. BBR is a potent drug with multiple targets and it is this multiplicity of function that makes BBR such a promising drug for targeting cell metabolism and proliferation.

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Berberine as a potential agent for breast cancer therapy

Cited by 35 publications

References 143 publications

Targeting lncRNAs of colorectal cancers with natural products

Targeting lncRNAs of colorectal cancers with natural products

Current understanding and future prospects on Berberine for anticancer therapy

Unravelling the Effects of Berberine on Metabolic Activity, Apoptosis and Proliferation of Transformed Cells

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