Berberine Attenuated Aging-Accelerating Effect of High Temperature in Drosophila Model

Navrotskaya, Valeriya; Oxenkrug, Gregory F.; Vorobyova, Lyudmila; Summergrad, Paul

doi:10.4236/ajps.2014.53037

Cited by 21 publications

(16 citation statements)

References 11 publications

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“…Finally, the alkaloid polyphenol berberine activates autophagy via SIRT1 and reduces protein acetylation (Shukla et al, 2016), protecting liver function (Sun et al, 2018), exerting neuroprotective effects (Wang et al, 2017), and reducing cardiac damage (Yu et al, 2016) in rodents. Berberine was also shown to extend the lifespan of Drosophila (Navrotskaya et al, 2012). Though oral bioavailability of berberine is poor (Liu et al, 2016), several clinical studies have been or are being performed with berberine supplementation.…”

Section: Resveratrol and Other Sirt1 Activatorsmentioning

confidence: 99%

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

et al. 2019

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Section: Resveratrol and Other Sirt1 Activatorsmentioning

confidence: 99%

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

et al. 2019

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“…It was previously observed that BBR inhibited mTOR/S6 signaling concurrent with the reduction in the level of endogenous oxidants and constitutive DNA damage response (Zhao, Halicka, Li, & Darzynkiewicz, ). BBR also prolonged lifespan and improved viability of the wild‐type Drosophila melanogaster pupae, and the climbing activity of adult insects at higher temperatures is known to accelerate aging in wild‐type flies (Navrotskaya, Oxenkrug, Vorobyova, & Summergrad, ).…”

Section: Introductionmentioning

confidence: 99%

Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression

Dang

et al. 2019

Aging Cell

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Although aging and senescence have been extensively studied in the past few decades, however, there is lack of clinical treatment available for anti‐aging. This study presents the effects of berberine (BBR) on the aging process resulting in a promising extension of lifespan in model organisms. BBR extended the replicative lifespan, improved the morphology, and boosted rejuvenation markers of replicative senescence in human fetal lung diploid fibroblasts (2BS and WI38). BBR also rescued senescent cells with late population doubling (PD). Furthermore, the senescence‐associated β‐galactosidase (SA‐β‐gal)‐positive cell rates of late PD cells grown in the BBR‐containing medium were ~72% lower than those of control cells, and its morphology resembled that of young cells. Mechanistically, BBR improved cell growth and proliferation by promoting entry of cell cycles from the G0 or G1 phase to S/G2‐M phase. Most importantly, BBR extended the lifespan of chemotherapy‐treated mice and naturally aged mice by ~52% and ~16.49%, respectively. The residual lifespan of the naturally aged mice was extended by 80%, from 85.5 days to 154 days. The oral administration of BBR in mice resulted in significantly improved health span, fur density, and behavioral activity. Therefore, BBR may be an ideal candidate for the development of an anti‐aging medicine.

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“…The family of IDO inhibitors were identifi ed among alkaloids isolated from Berberis aristata , a herb widely used in Indian and Chinese systems of medicine (Yu et al 2010 ). One of them, berberine, improves IR in diabetic hamsters ) and diabetic patien ts (Zhao et al 2012 ;Di Pierro et al 2012 ) and prolonged life span and improved health span in Drosophila model (Navrotskaya et al 2012(Navrotskaya et al , 2014.…”

Section: Resultsmentioning

confidence: 99%

3-Hydroxykynurenic Acid and Type 2 Diabetes: Implications for Aging, Obesity, Depression, Parkinson’s Disease, and Schizophrenia

Oxenkrug

2015

Tryptophan Metabolism: Implications for Biological Processes, Health and Disease

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Aging, obesity, depression, Parkinson's and other neurodegenerative diseases, schizophrenia, and treatment with antipsychotic drugs are highly associated with insulin resistance (IR) and type 2 diabetes mellitus (T2D). Molecular mechanisms of increased associations remain uncertain. Current review of literature and our data suggest that one such mechanism is the overproduction of diabetogenic factors resulting from dysregulation of upstream and downstream pathways of tryptophan (TRP)-kynurenine (KYN) metabolism. Proinfl ammatory factors and stress hormones activate two upstream steps of TRP-KYN pathway: TRP conversion into KYN, a substrate for formation of kynurenic acid (KYNA), and KYN conversion into 3-hydroxyKYN (3-HK). The fi rst step of downstream pathway of 3-HK metabolism, formation of 3-hydroxyanthranilic acid (3-HAA), is catalyzed by pyridoxal-5-phosphate (P5P)-dependent kynureninase (KYNase). P5P defi ciency, associated with infl ammation, stress, and treatment with antipsychotic drugs, diverts metabolism of overproduced 3-HK from formation of 3-HAA to the excessive formation of 3-hydroxykynurenic acid (3H-KYNA). Human and experimental studies suggested diabetogenic (e.g., impairment of production, release, and biological activity of insulin) effect of KYN, 3H-KYNA, KYNA, and their metabolites. We propose that one of the mechanisms of increased association of IR (and T2D) with aging, obesity, depression, neurodegenerative diseases, schizophrenia, and treatment with antipsychotic drugs is overproduction of 3H-KYNA resulting from upregulated formation of 3-HK augmented by P5P defi ciency. Pharmacological regulation of upand downstream TRP-KYN metabolic pathways might be a new approach for prevention and treatment of IR (and IR progression to T2D) associated with aging, obesity, depression, neurodegenerative diseases, schizophrenia, and treatment with antipsychotic drugs.

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Berberine Attenuated Aging-Accelerating Effect of High Temperature in Drosophila Model

Cited by 21 publications

References 11 publications

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression

3-Hydroxykynurenic Acid and Type 2 Diabetes: Implications for Aging, Obesity, Depression, Parkinson’s Disease, and Schizophrenia

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