Berberine from Argemone mexicana L exhibits a broadspectrum antibacterial activity

More, Nilesh V; Kharat, Kiran; Kharat, Arun S.

doi:10.18388/abp.2017_1621

Cited by 28 publications

(15 citation statements)

References 19 publications

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“…Furthermore, the bacterial community was driven away from the Nor group along PC1 and was closer to the Nor group along PC2 in the Sta + BBR group in comparison to the BBR group (Figure d). Thus, both berberine alone and berberine with stachyose reduced the diversity and richness of microbiota, which may mainly result from the broad antibacterial action of berberine (More et al, ), which is only minimally reversed by the prebiotic stachyose. No significant differences were found between the BBR and Sta + BBR groups.…”

Section: Resultsmentioning

confidence: 99%

“…(Berberidaceae), has been reported to exert many therapeutic effects, including anti‐diabetes, lipid‐lowering, and anti‐cancer. Currently, berberine is primarily obtained by chemical synthesis and is used in China in the treatment of diarrhea for its effects on intestines and its antibacterial effects (Imenshahidi & Hosseinzadeh, ; More, Kharat, & Kharat, ). Although berberine is also used in obese diabetic patients, its poor intestinal absorption may induce different degrees of diarrhea in some patients (Imenshahidi & Hosseinzadeh, ) and therefore prevents long‐term and wide application in the treatment of Type 2 diabetes mellitus (T2DM).…”

Section: Introductionmentioning

confidence: 99%

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Berberine combined with stachyose induces better glycometabolism than berberine alone through modulating gut microbiota and fecal metabolomics in diabetic mice

Wang

Lei

et al. 2019

Phytotherapy Research

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Berberine (BBR), a small alkaloid, is used as a hypoglycemic agent in China. Stachyose (Sta), a Rehmannia glutinosa oligosaccharide, acts as a prebiotic. This study aimed to evaluate whether BBR combined with Sta produced better glycometabolism than BBR alone, and explored the effects on gut microbiota and metabolomics. Type-2 diabetic db/db mice were administered BBR (100 mg/kg), Sta (200 mg/kg), or both by gavage once daily. Glucose metabolism, the balance of αand β-cells, and mucin-2 expression were ameliorated by combined treatment of BBR and Sta, with stronger effects than upon treatment with BBR alone. The microbial diversity and richness were altered after combined treatment and after treatment with BBR alone. The abundance of Akkermansia muciniphila was increased by combined treatment compared to treatment with BBR alone, while the levels of the metabolite all-transheptaprenyl diphosphate were decreased and the levels of fumaric acid were increased, which both showed a strong correlation with A. muciniphila. In summary, BBR combined with Sta produced better glycometabolism than BBR alone through modulating gut microbiota and fecal metabolomics, and may aid in the development of a novel pharmaceutical strategy for treating Type 2 diabetes mellitus. K E Y W O R D Sberberine, metabolomics, microbiota, stachyose, type 2 diabetes

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Berberine combined with stachyose induces better glycometabolism than berberine alone through modulating gut microbiota and fecal metabolomics in diabetic mice

Wang

Lei

et al. 2019

Phytotherapy Research

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“…12 Pharmacological studies using doses of berberine (50-200 mg/kg per time, one time a day) 13 substantially exceed those likely to occur in humans (0.1-0.3 g per time, three times a day) have demonstrated that berberine has a broad-spectrum antibiotic activity, including Vibrio cholera, Shigella and Pseudomonas [14][15][16] and have approved that berberine has advantages in treating intestinal bacterial infections, including bacterial dysentery and viral infections. 10,[17][18][19][20] Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis can also be suppressed by berberine. 21 In addition, berberine has broad prospects in the treatment of secretory diarrhea, it can inhibit the hypersecretion of electrolytes caused by cholera toxin.…”

Section: Introductionmentioning

confidence: 99%

Berberine for diarrhea in children and adults: a systematic review and meta-analysis

Jin

Liang

et al. 2020

Therap Adv Gastroenterol

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Background: Diarrhea is a ubiquitous digestive system disease, leading to loss of fluid and electrolytes, and may be life-threatening, especially in children and adults who are immunosuppressed or malnourished. Berberine has a broad-spectrum antibiotic activity and is very widely used to treat diarrhea in China. No systematic review has been carried out to evaluate the evidence presented in clinical trials. The aim of this study was to assess the effectiveness and safety of berberine in diarrhea treatment among children and adults. Methods: Seven databases and two clinical trial registries were searched on 1 September 2019. Randomized controlled trials were included, where participants were diagnosed (first diagnosed) as having diarrhea according to clear diagnostic criteria. Berberine alone or in combination with Western medication as intervention were included. Subgroup analyses were conducted based on children or adults, acute or persistent diarrhea, infectious or noninfectious and treatment courses. Primary outcomes were clinical cure rate and duration of diarrhea. The GRADE tool was used to assess the quality of evidence. Results: A total of 38 randomized controlled trials were included involving 3948 participants (including 27 trials on 2702 children) were included. Compared with antibiotics, berberine plus antibiotics showed better results in both adults and in children in general, especially when given for 7 days or 3 days in acute infectious diarrhea of children. Compared with the control groups, using berberine alone or in combination with montmorillonite, probiotics, and vitamin B increased the clinical cure rate of diarrhea. The use of berberine alone or berberine combined with montmorillonite reduced the duration of hospitalization. Using berberine had significantly better laboratory indicators (isoenzyme, inflammatory factors, myocardial enzyme, and fecal trait) and fewer systemic symptoms than the no berberine groups. Overall, 22 of 27 trials on children used berberine as an enema. No deaths and serious adverse events were reported. The quality of evidence of included trials was moderate to low or very low. The impact of different dosages, frequencies and treatment durations on the outcomes was not evaluated due to insufficient number of trials. Conclusion: This review demonstrated that berberine was generally effective in improving clinical cure rates and shortening the duration of diarrhea compared with control groups. No severe adverse event was reported. However, there is still a lack of high-quality evidence for evaluating the efficacy and safety of berberine. Trial registration: PROSPERO CRD42020151001 (available from http://www.crd.york.ac.uk/PROSPERO/ ).

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“…in a mice study [20]. In addition to anti-inflammation effect of berberine, baicalin and geniposide, berberine also has anti-bacterial activity [21,22]. Therefore, the potential anti-inflammation and anti-bacterial effects of these compounds in mHLJD decoction cream might constitute of the therapeutic effect in this trial.…”

Section: Discussionmentioning

confidence: 90%

Alleviation of EGFR Tyrosine Kinase Inhibitor-induced Skin Toxicity by Modified Huang-Lian-Jie-Du Decoction Cream in Cancer Patients

Lee

Lin

Chang

et al. 2020

Preprint

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Background. The EGFRIs and TKIs are effective for cancer target therapy, but the acneiform rashes or called inflammatory papulopustular exanthemas are common (50% to 100%). The conventional therapy for EGFRIs/TKIs-induced skin toxicity is steroids and antibiotics, but their effect is still limited. In this study, a modified Chinese herbal medicine Huang Lian Jie Du decoction cream with Yin-Cold (YC) medicine characteristic was investigated for the effect on patients suffering EGFRIs/TKIs-induced skin toxicity.Methods. The modified Huang Lian Jie Du (mHLJD) decoction cream was made from 10 herbal medicines including 4 major medicines (Huanglian, Huangqin, Huangbo, and Zhizi) in traditional HLJD decoction. Patients with EGFRIs/TKIs-induced skin toxicity were enrolled. Patients were excluded if they also used other cream for the skin toxicity. Skin conditions were follow up every 2 weeks. The patients’ characteristics, the skin toxicities and treatment response were recorded and analyzed after using mHLJD decoction cream for 1~2 months.Results. The mHLJD decoction cream and its subpackages were stored at 4℃ before use. Thirty-four patients who had grade 1-3 skin toxicities after receiving EGFRIs or TKIs were enrolled. Five patients were withdrawal or excluded, 2 patients with paronychia syndrome had no improvement and were excluded, too. Finally, data from 27 patients were analyzed. The mean grade of rash acneiform was decreased from 2.23 (ranged 1 to 3) to 0.38 (ranged 0 to 1) after mHLJD decoction cream treatment for 1~2 months. And the mean grade of dry skin was decreased from 1.57 (ranged 1 to 2) to 0.77 (ranged 0 to 1). The changes of skin toxicity were significant and no obvious adverse events.Conclusions. In summary, the mHLJD decoction cream is effective for alleviation of EGFRIs/TKIs-induced skin rash acneiform and dry skin. And mHLJD decoction cream has no effect in patients with paronychia syndrome.

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Berberine from Argemone mexicana L exhibits a broadspectrum antibacterial activity

Cited by 28 publications

References 19 publications

Berberine combined with stachyose induces better glycometabolism than berberine alone through modulating gut microbiota and fecal metabolomics in diabetic mice

Berberine combined with stachyose induces better glycometabolism than berberine alone through modulating gut microbiota and fecal metabolomics in diabetic mice

Berberine for diarrhea in children and adults: a systematic review and meta-analysis

Alleviation of EGFR Tyrosine Kinase Inhibitor-induced Skin Toxicity by Modified Huang-Lian-Jie-Du Decoction Cream in Cancer Patients

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