Berberine improves reproductive features in obese Caucasian women with polycystic ovary syndrome independently of changes of insulin sensitivity

Orio, Francesco; Muscogiuri, Giovanna; Palomba, Stefano; Savastano, Silvia; Volpe, A.; Orio, Marcello; Colarieti, Giorgio; Sala, Giovanni Battista La; Colao, Annamaria; Marcianò, F.; Arillo, Antonio; Putignano, Pietro

doi:10.1016/j.clnme.2013.07.002

Cited by 19 publications

(30 citation statements)

References 29 publications

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“…Regarding specifically side effects, 3 out of 31 subjects (BBR group) complained of a bitter taste in their mouth versus 9 out of 30 subjects (MET group) suffered by nausea, vomiting, mild diarrhea and flatulence [19]. No adverse events were observed by Cicero et al [21] and Orio et al [25], while An et al reported 1/50 subject (BBR group) transient gastrointestinal side effects including diarrhea vs. 2/50 subjects (Met group) gastrointestinal side effects including diarrhea [22]. Wu et al reported that 1 subject out of 214 subject (BBR group) had constipation and nausea, no fetal abnormalities in BBR group versus 1 fetal abnormality in letrozole group resulting in termination of pregnancy [24].…”

Section: Resultsmentioning

confidence: 90%

“…Women enrolled by Wei et al and An et al received lifestyle and nutritional counseling before the treatment with berberine, metformin or placebo [19,22]; while in the study conducted by Orio et al, no lifestyle modifications were implemented [25] in spite of the fact that a good lifestyle has been demonstrated to be crucial to the amelioration of symptoms related to PCOS [3]. Only Cicero et al before the beginning of the study gave a three-month lipid-lowering diet to enrolled women [21].…”

Section: Resultsmentioning

confidence: 99%

“…Women affected by PCOS showed an impaired fasting glucose control and insulin resistance, and this aspect was investigated by all authors except Wu and colleagues [24]. Parameters taken into consideration from the authors were fasting glucose, fasting insulin, the HOMA index and the AUC INS ; in all studies, berberine showed an improvement of the parameters with a reduction of insulin resistance in a statistically significant way only in berberine groups vs. placebo (p < 0.01 or p < 0.05), so berberine reduced insulin resistance but is not superior to metformin [19,21,22,25]. All these authors also analyzed changes in the lipid profiles of PCOS women, and demonstrated that berberine improved, in all patients, HDL cholesterol and reduced total cholesterol and LDL cholesterol [19,21,22,25].…”

Section: Resultsmentioning

confidence: 99%

“…All research groups had analyzed the effect of berberine on women affected by PCOS, but nutraceutical and drugs formulations used were quite different; in particular, Wei et al and An et al administered berberine hydrochloride 500 mg three times/day [19,22], and Orio et al administered a tablet twice a day, with 588 mg of Berberis aristata extract tittered as 85% of berberine [25]. Cicero et al tested a nutraceutical compound tablet with 500 mg of berberine plus 3 mg of monacolins [21]; Wu et al administered berberine in a daily dose of 1.5 g [24].…”

Section: Resultsmentioning

confidence: 99%

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Polycystic ovary syndrome management: a review of the possible amazing role of berberine

Rondanelli

Infantino

Riva

et al. 2020

Arch Gynecol Obstet

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Purpose The therapy of polycystic ovary syndrome (PCOS) is based on synthetic hormones associated with lifestyle changes, but these therapies cannot be taken continuously, especially by women who would like to become pregnant. Thus, nutraceutical compounds were investigated as possible agents for treatment of PCOS. Berberine is shown to be effective against insulin resistance and obesity, particularly against visceral adipose tissue (VAT). Because of these properties, researchers theorized that berberine could be effective in PCOS treatment. Methods The aim of this narrative review was to assess the state of the art about the use of berberine in PCOS management. Results This review included 5 eligible studies. Despite the number of studies considered being low, the number of women studied is high (1078) and the results are interesting. Two authors find out that berberine induced a redistribution of adipose tissue, reducing VAT in the absence of weight loss and improved insulin sensitivity, quite like metformin. One author demonstrated that berberine improved the lipid pattern. Moreover, three authors demonstrated that berberine improved insulin resistance in theca cells with an improvement of the ovulation rate per cycle, so berberine is also effective on fertility and live birth rates. Conclusions Finally, berberine is safe to use in premenopausal women who want to get pregnant and showed few side effects in all the cited studies. In conclusion, the use of berberine for PCOS is safe and promising, even if more studies are needed to create a consensus about the dosage of berberine useful for long-term therapy.

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Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Polycystic ovary syndrome management: a review of the possible amazing role of berberine

Rondanelli

Infantino

Riva

et al. 2020

Arch Gynecol Obstet

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“…None of the studies seem to be favorable to controls, but from the forest plot it can be noted that of the 19 analyzed studies, three do not reach the threshold of statistical significance: Orio et al 24 with ES 0.08 (-0.31 to -0.48), Pirillo et al 38 with ES 0.00 (-0.45 to 0.45), and Solà et al 40 with ES -0.35 (-0.74 to 0.04).…”

Section: Effects On Tcmentioning

confidence: 98%

Berberine and Dyslipidemia: Different Applications and Biopharmaceutical Formulations Without Statin-Like Molecules—A Meta-Analysis

Bertuccioli

Moricoli

Amatori

et al. 2020

Journal of Medicinal Food

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The aim of this study was to analyze the efficacy of berberine taken alone or in other formulations (with silymarin or other mixtures) on dyslipidemia through a systematic review of the literature and a meta-analysis. A systematic investigation was conducted on 19 studies that were selected based on inclusion and exclusion criteria. Both controlled trials (n = 12) and cross-sectional trials (n = 7) were included. The following formulations were examined: berberine used alone (n = 5), berberine combined with silymarin (n = 8), and other mixture containing berberine (n = 6). A meta-analysis was performed using a fixed-effects model and meta-regression. Total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, highdensity lipoprotein (HDL) cholesterol, and triglycerides were considered. Moreover, possible associations of each parameter with age and the dose and duration of the treatment were analyzed. The data obtained showed a significant reduction in TC and LDL cholesterol for each formulation. A reduction in triglycerides was also observed for both TC and LDL but with a smaller impact. As regards HDL, a slight increase was observed, but it was not statistically significant. The formulation of berberine in association with silymarin was found to have the greatest impact on TC, LDL, HDL, and triglycerides. The greater efficacy of the formulation consisting of berberine associated with silymarin can probably be accounted for by the fact that the latter increases the bioavailability of berberine. However, it is necessary to carry out further clinical studies to better define the efficacy of the treatment and which patients show the best response.

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Effect and mechanism of berberine against polycystic ovary syndrome

Zhang

Zhou

Gober

et al. 2021

Biomedicine & Pharmacotherapy

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Berberine improves reproductive features in obese Caucasian women with polycystic ovary syndrome independently of changes of insulin sensitivity

Cited by 19 publications

References 29 publications

Polycystic ovary syndrome management: a review of the possible amazing role of berberine

Polycystic ovary syndrome management: a review of the possible amazing role of berberine

Berberine and Dyslipidemia: Different Applications and Biopharmaceutical Formulations Without Statin-Like Molecules—A Meta-Analysis

Effect and mechanism of berberine against polycystic ovary syndrome

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