Bergapten alleviates depression-like behavior by inhibiting cyclooxygenase 2 activity and NF-κB/MAPK signaling pathway in microglia

Yan, Meichen; Bo, Xuena; Zhang, Jingdan; Liu, Shuhan; Li, Xiaoheng; Liao, Yuhe; Liu, Qingshan; Cheng, Yong; Cheng, Jinbo

doi:10.1016/j.expneurol.2023.114426

Cited by 10 publications

(3 citation statements)

References 37 publications

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“…BGP-3, however, failed to reduce the marker of renal inflammation compared to CPM 200, except for the level of TNF-α, as shown in Figures and , respectively. The findings of our study correlate with the previously published study where BGP exhibited significant anti-inflammatory activity in various preclinical models. ,, …”

Section: Discussionmentioning

confidence: 99%

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Nephroprotective Effect of Bergapten Against Cyclophosphamide-Mediated Renal Stress, Inflammation, and Fibrosis in Wistar Rats: Probable Role of NF-kB and TGF-β1 Signaling Molecules

Mohsin,

Akhtar,

Alkahtani

et al. 2024

ACS Omega

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Cyclophosphamide (CPM) is a well-established antineoplastic drug with marked clinical outcomes in various types of cancers. Despite being a promising drug, its use is associated with significant renal toxicity and often limits its use, leading to compromised clinical outcomes. Therefore, this study explored the renal protective effect of bergapten (BGP), a natural bioactive compound that showed marked antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. Till now, BGP has not been studied for its renal protective effect in an in vivo model. Animals were divided into control, toxic, BGP-3, BGP-10, and BGP Per se. The control group was treated with normal saline for 2 weeks. To the toxic group, CPM 200 mg/kg was given on day 7 as i.p. To BGP-3, 10, and Per se, BGP-3 and 10 mg/kg, ip was given 2 weeks with a single shot of CPM 200 day 7. To the Per se group, only BGP 10 mg/kg, ip was given from day 1 to day 14. After 14 days, animals were sacrificed, and kidneys were removed and studied for the markers of oxidative stress, inflammation, renal injury, renal fibrosis, and renal damage using biochemical, histopathological, and immunohistochemical studies. We found that BGP-10 effectively reversed the damage toward normal, whereas BGP-3 failed to exhibit a significant renal protective effect. We conclude that bergapten could be a potential renal protective drug, and hence, more detailed cellular molecular-based studies are needed to bring this drug from the bench to the bedside.

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Section: Discussionmentioning

confidence: 99%

“…The findings of our study correlate with the previously published study where BGP exhibited significant anti-inflammatory activity in various preclinical models. 20 ,, 22 …”

Section: Discussionmentioning

confidence: 99%

Nephroprotective Effect of Bergapten Against Cyclophosphamide-Mediated Renal Stress, Inflammation, and Fibrosis in Wistar Rats: Probable Role of NF-kB and TGF-β1 Signaling Molecules

Mohsin,

Akhtar,

Alkahtani

et al. 2024

ACS Omega

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“…Our studies showed that conditional deletion of microglial Dlg1 significantly inhibited the NF-κB signaling activation in microglia, and alleviated lipopolysaccharides (LPS)-induced and chronic restraint stress-induced depression-like behaviors in mice ( 30 , 31 ). Moreover, treatment of Bergapten inhibited microglial activation and alleviated LPS-induced depression-like behavior in mice ( 32 ). Collectively, microglial activation-induced neuroinflammation was critical in the development of these diseases, and targeting neuroinflammation might be a promising strategy in the clinical treatment.…”

Section: Inflammation Contributes To Neuropathologymentioning

confidence: 99%

Role and regulatory mechanism of microRNA mediated neuroinflammation in neuronal system diseases

Zhang

et al. 2023

Front. Immunol.

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MicroRNAs (miRNAs) are small non-coding RNAs with the unique ability to degrade or block specific RNAs and regulate many cellular processes. Neuroinflammation plays the pivotal role in the occurrence and development of multiple central nervous system (CNS) diseases. The ability of miRNAs to enhance or restrict neuroinflammatory signaling pathways in CNS diseases is an emerging and important research area, including neurodegenerative diseases, stroke, and traumatic brain injury (TBI). In this review, we summarize the roles and regulatory mechanisms of recently identified miRNAs involved in neuroinflammation-mediated CNS diseases, aiming to explore and provide a better understanding and direction for the treatment of CNS diseases.

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Quality assessment and Q‐markers discovery in Citri Sarcodactylis Fructus by integrating serum pharmacochemistry and network pharmacology

Li,

Zhang,

Liu

et al. 2024

Phytochemical Analysis

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IntroductionCitri Sarcodactylis Fructus (CSF), a common fruit and traditional Chinese medicine (TCM), has been hindered in its further development and research owing to the lack of comprehensive and specific quality evaluation standards.ObjectiveThis study aimed to establish clear TCM quality standards related to the therapeutic mechanisms of CSF and to provide a basis for subsequent research and development.MethodsUltra‐high performance liquid chromatography coupled with hybrid quadrupole‐orbitrap high‐resolution mass spectrometry (UPLC‐Q‐orbitrap HRMS) technology was used to comprehensively identify CSF components and explore their absorbance levels in rat serum. Network pharmacology research methods were employed to investigate the potential mechanisms of action of the identified components in the treatment of major clinical diseases. Subsequently, a combination of HPLC chromatographic fingerprinting for qualitative analysis and multi‐index content determination was used to evaluate the detectability of the identified quality markers (Q‐markers).ResultsTwenty‐six prototype components were tentatively characterized in rat serum. Network pharmacology analysis showed six effective components, namely 7‐hydroxycoumarin, isoscopoletin, diosmin, hesperidin, 5,7‐dimethoxycoumarin, and bergapten, which played important roles in the treatment of chronic gastritis, functional dyspepsia, peptic ulcer, and depression and were preliminarily identified as Q‐markers. The results of content determination in 15 batches of CSF indicated significant differences in the content of medicinal materials from different origins. However, compared with the preliminarily determined Q‐markers, all six components could be measured and were determined as Q‐markers of CSF.ConclusionThe chemical Q‐markers obtained in this study could be used for effective quality control of CSF.

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Bergapten alleviates depression-like behavior by inhibiting cyclooxygenase 2 activity and NF-κB/MAPK signaling pathway in microglia

Cited by 10 publications

References 37 publications

Nephroprotective Effect of Bergapten Against Cyclophosphamide-Mediated Renal Stress, Inflammation, and Fibrosis in Wistar Rats: Probable Role of NF-kB and TGF-β1 Signaling Molecules

Nephroprotective Effect of Bergapten Against Cyclophosphamide-Mediated Renal Stress, Inflammation, and Fibrosis in Wistar Rats: Probable Role of NF-kB and TGF-β1 Signaling Molecules

Role and regulatory mechanism of microRNA mediated neuroinflammation in neuronal system diseases

Quality assessment and Q‐markers discovery in Citri Sarcodactylis Fructus by integrating serum pharmacochemistry and network pharmacology

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