Bergapten ameliorates combined allergic rhinitis and asthma syndrome after PM2.5 exposure by balancing Treg/Th17 expression and suppressing STAT3 and MAPK activation in a mouse model

Jiang, Yao; Nguyen, Thi Van; Jin, Juan; Yu, Zhen Nan; Song, Chang Ho; Chai, Ok Hee

doi:10.1016/j.biopha.2023.114959

Cited by 17 publications

(4 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While exposure to PM2.5 (100 µg/mouse for 30 days) aggravates OVAinduced combined allergic rhinitis and asthma syndrome (CARAS) with massive lung inflammation and lung injury in mice, treatment of mice with Bergapten (3,10,30 mg/kg) induces OVA-specific IgG2A and decreases the level of IgE and IgG1 in serum. Most importantly, Bergapten reduces the inflammation in nasal mucosa and lungs through induction of Th1 cytokine IL-12, IFN-and reduction of Th2 cytokines IL-4, IL-5, and IL-13 [62]. These results indicate that Bergapten is a potential natural therapeutic agent to treat CARAS and PM2.5-induced worst lung pathologies.…”

Section: Lessons From Studies Using Animal Models and Natural Compoundsmentioning

confidence: 73%

Air-pollutant Particulate Matter 2.5 (PM2.5)-induced Inflammation and Oxidative Stress in Diseases: Possible Therapeutic Approaches

Ghosh

2023

Preprint

View full text Add to dashboard Cite

Today, air pollution is the greatest threat to organismal healthspan. The environment of our planet earth, the habitat of over eight billion humans and estimated twenty billion billions other animals, is contaminated with a wide variety of pollutants. Unfortunately, humans, out of billions and billions of living organisms on earth, are solely responsible for polluting the environment through emitting pollutants like particulate matter from industry, fuel engine vehicles, biomass combustion, toxic fumes from blasting, and wildfire. In the modern world, human-caused air pollutants induce massive oxidative stress and inflammation, the major contributors in initiation and progression of many diseases including pulmonary, cardiovascular, renal, hepatic, reproductive, neurological, mental, and accelerated biological aging. The provocative question is the following: how can we solve this human-created problem? As it is not realistic to clean the environment at once from human-caused pollution, initiatives have been undertaken to develop novel therapeutic approaches to control air-pollutant-induced oxidative stress and inflammation to protect humans from pollution-induced devastating diseases. In this article, I discuss the key findings of numerous recent preclinical studies documenting first, the role of air pollutant PM2.5 in augmentation of inflammation, oxidative stress, and associated diseases; and second, the efficacies of different natural and synthetic compounds in amelioration of PM2.5-induced oxidative stress, inflammation, pyroptosis, and associated pathologies.

show abstract

Section: Lessons From Studies Using Animal Models and Natural Compoundsmentioning

confidence: 73%

Air-pollutant Particulate Matter 2.5 (PM2.5)-induced Inflammation and Oxidative Stress in Diseases: Possible Therapeutic Approaches

Ghosh

2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The smaller the particles are, the more they sediment into the lower airways, which allows them to affect the alveolar–capillary barrier directly [ 13 ]. They trigger cytotoxicity, leading to a local and systemic inflammatory response (via cytokines and mediators) [ 92 ]. Similar results were shown in a meta-analysis conducted by Liu et al [ 93 ].…”

Section: Discussionmentioning

confidence: 99%

Does Exposure to Ambient Air Pollution Affect Gestational Age and Newborn Weight?—A Systematic Review

Grabowski,

Feduniw,

Orzel

et al. 2024

Healthcare

View full text Add to dashboard Cite

Current evidence suggests that airborne pollutants have a detrimental effect on fetal growth through the emergence of small for gestational age (SGA) or term low birth weight (TLBW). The study’s objective was to critically evaluate the available literature on the association between environmental pollution and the incidence of SGA or TLBW occurrence. A comprehensive literature search was conducted across Pubmed/MEDLINE, Web of Science, Cochrane Library, EMBASE, and Google Scholar using predefined inclusion and exclusion criteria. The methodology adhered to the PRISMA guidelines. The systematic review protocol was registered in PROSPERO with ID number: CRD42022329624. As a result, 69 selected papers described the influence of environmental pollutants on SGA and TLBW occurrence with an Odds Ratios (ORs) of 1.138 for particulate matter ≤ 10 μm (PM10), 1.338 for particulate matter ≤ 2.5 μm (PM2.5), 1.173 for ozone (O3), 1.287 for sulfur dioxide (SO2), and 1.226 for carbon monoxide (CO). All eight studies analyzed validated that exposure to volatile organic compounds (VOCs) is a risk factor for SGA or TLBW. Pregnant women in the high-risk group of SGA occurrence, i.e., those living in urban areas or close to sources of pollution, are at an increased risk of complications. Understanding the exact exposure time of pregnant women could help improve prenatal care and timely intervention for fetuses with SGA. Nevertheless, the pervasive air pollution underscored in our findings suggests a pressing need for adaptive measures in everyday life to mitigate worldwide environmental pollution.

show abstract

“…On the other hand, bergapten was able to ameliorate the inflammatory symptoms associated with combined allergic rhinitis and asthma syndrome (CARAS) in a mouse model. Indeed, the administration of bergapten limited the release of pro-inflammatory cytokines, the activation of STAT3 and MAPKs signaling pathways, the infiltration of inflammatory cells and collagen deposition at the level of nasal mucosa and lung tissue [ 72 ]. Table 2 shows the effects of BEO on inflammatory-based respiratory ailments.…”

Section: Anti-inflammatory Activity Of Bergamot Derivatives and Bypro...mentioning

confidence: 99%

Bergamot Byproducts: A Sustainable Source to Counteract Inflammation

Russo,

Lombardo,

Bruschetta

et al. 2024

Nutrients

View full text Add to dashboard Cite

Chronic inflammation is the result of an acute inflammatory response that fails to eliminate the pathogenic agent or heal the tissue injury. The consequence of this failure lays the foundations to the onset of several chronic ailments, including skin disorders, respiratory and neurodegenerative diseases, metabolic syndrome, and, eventually, cancer. In this context, the long-term use of synthetic anti-inflammatory drugs to treat chronic illnesses cannot be tolerated by patients owing to the severe side effects. Based on this, the need for novel agents endowed with anti-inflammatory effects prompted to search potential candidates also within the plant kingdom, being recognized as a source of molecules currently employed in several therapeutical areas. Indeed, the ever-growing evidence on the anti-inflammatory properties of dietary polyphenols traced the route towards the study of flavonoid-rich sources, such as Citrus bergamia (bergamot) and its derivatives. Interestingly, the recent paradigm of the circular economy has promoted the valorization of Citrus fruit waste and, in regard to bergamot, it brought to light new evidence corroborating the anti-inflammatory potential of bergamot byproducts, thus increasing the scientific knowledge in this field. Therefore, this review aims to gather the latest literature supporting the beneficial role of both bergamot derivatives and waste products in different models of inflammatory-based diseases, thus highlighting the great potentiality of a waste re-evaluation perspective.

show abstract

Bergapten ameliorates combined allergic rhinitis and asthma syndrome after PM2.5 exposure by balancing Treg/Th17 expression and suppressing STAT3 and MAPK activation in a mouse model

Cited by 17 publications

References 54 publications

Air-pollutant Particulate Matter 2.5 (PM2.5)-induced Inflammation and Oxidative Stress in Diseases: Possible Therapeutic Approaches

Air-pollutant Particulate Matter 2.5 (PM2.5)-induced Inflammation and Oxidative Stress in Diseases: Possible Therapeutic Approaches

Does Exposure to Ambient Air Pollution Affect Gestational Age and Newborn Weight?—A Systematic Review

Bergamot Byproducts: A Sustainable Source to Counteract Inflammation

Contact Info

Product

Resources

About