Beryllium hypersensitivity and chronic beryllium lung disease

Tomas, Linus H. Santo

doi:10.1097/mcp.0b013e3283218341

Cited by 19 publications

(3 citation statements)

References 35 publications

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“…Berylliosis diagnosis involves establishing beryllium sensitivity, which is done by performing a beryllium lymphocyte proliferation test (BeLPT) using peripheral blood or bronchoalveolar lavage (BAL) fluid [75]. Lymphocytes are cultured with beryllium sulfate, and a high number of abnormal cells are counted [74,75]. Those with two abnormal BeLPTs with peripheral blood or one abnormal and one borderline result are considered beryllium sensitized.…”

Section: Berylliosismentioning

confidence: 99%

“…Bronchoscopy with BAL is performed for patients with a positive BeLPT to obtain cell counts [76]. A tissue biopsy is obtained from bronchoscopy to fulfill the final criterion for CBD diagnosis: the presence of granulomatous inflammation on lung biopsy [75,76]. The imaging findings of berylliosis are also not specific.…”

Section: Berylliosismentioning

confidence: 99%

“…Hilar lymphadenopathy, interstitial pulmonary fibrosis, and pleural thickening are typical later-stage findings. Other tests that may be used to diagnose berylliosis include arterial blood gas, pulmonary function tests, spirometry, and DLCO levels [70,75]. The differential diagnosis for berylliosis includes sarcoidosis, idiopathic pulmonary fibrosis, hypersensitivity pneumonitis, asthma, and other granulomatous lung diseases like histoplasmosis, tuberculosis, and silicosis [67,69].…”

Section: Berylliosismentioning

confidence: 99%

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Understanding Pneumoconiosis, A Misdiagnosed Subtype of Diffuse Interstitial Lung Disease

Coral

2023

IJOPRS

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Pneumoconiosis is a lung disease caused by inhalation of organic or nonorganic airborne dust and fibers for an extended period. The clinical presentation can vary depending on the dust type and the disease's severity. Common symptoms include cough, shortness of breath, chest tightness, and wheezing. Pneumoconiosis is one of the most common occupational diseases in the world. The most frequent types include asbestosis, silicosis, anthracosis, berylliosis, siderosis, and talcosis. It is important to note that there are other types of pneumoconiosis. However, due to their exceptionally rare occurrence, they are not addressed in this review. Diagnosis of pneumoconiosis typically involves a thorough medical history, physical examination, and imaging tests such as chest X-rays and CT scans. Pulmonary function tests may also be used to assess lung function. The prognosis of pneumoconiosis depends on several factors, including the type and severity of the disease, as well as the patient's age, overall health, and exposure to the causative dust. In some cases, the condition may progress and lead to severe respiratory impairment, while in other cases, the symptoms may be mild and manageable with treatment. Treatment strategies are mainly tailored to avoid further exposure to inhalants, smoking suspension, pulmonary rehabilitation, and symptomatic treatment. Patients with end-stage disease may be candidates for lung transplants. This narrative review article presents an overview of the most common types of pneumoconiosis.

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Section: Berylliosismentioning

confidence: 99%