.BETA.2- and .BETA.3-Adrenoceptor Polymorphisms Relate to Subsequent Weight Gain and Blood Pressure Elevation in Obese Normotensive Individuals

Kawaguchi, Hideki; Masuo, Kazuko; Katsuya, Tomohiro; Sugimoto, Ken; Rakugi, Hiromi; Ogihara, Toshio; Tuck, Michael L.

doi:10.1291/hypres.29.951

Cited by 41 publications

(30 citation statements)

References 48 publications

(45 reference statements)

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“…We found that the participants with the Arg allele were more apt to gain weight when compared to those without the Arg allele. This is consistent with previous reports examining the relation between the Trp64Arg polymorphism and long-term weight gain in obese people (Kawaguchi et al, 2006). Kawaguchi et al (2006) found that when compared, the obese normotensive subjects who had a significant weight gain, over a 5-year period, carried higher frequencies of the Arg64 allele of the ADRB3 than subjects without a significant weight gain.…”

Section: Discussionsupporting

confidence: 93%

“…However, there have been few reports examining a similar association on long-term weight change in obese people. Recently, Kawaguchi et al (2006) showed that the Trp64Arg polymorphism of the ADRB3 was associated with weight gain over a 5-year period in obese Japanese men. However, this finding has not been confirmed in another study (Shiwaku et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

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The Trp64Arg Polymorphism of the β3-adrenergic Receptor Gene is Associated with Weight Changes in obese Japanese Men: A 4-year Follow-up Study

Yamakita

Ando

Tang

et al. 2010

J Physiol Anthropol

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The aim of this study was to investigate whether the Trp64Arg polymorphism of the b 3 -adrenergic receptor gene (ADRB3) is associated with weight changes in obese Japanese men at 4-year follow-up. The participants were 145 obese Japanese men [age: 35.8Ϯ5.3 y; body mass index (BMI): 27.5Ϯ3.3 kg/m 2 ]. The participants were divided into two groups according to the Trp64Arg genotype: (1) with the Arg64 allele of the ADRB3 (Trp64Arg and Arg64Arg genotypes, nϭ50); (2) without the Arg64 allele of the ADRB3 (Trp64Trp genotype, nϭ95). The ADRB3 genotyping was performed by denaturing high performance liquid chromatography (DHPLC). Body weight, BMI, and blood pressure were determined at baseline and at 4 years. After 4 years, the participants with the Arg allele of the ADRB3 significantly increased their body weight (2.1Ϯ4.7 kg, pϭ0.002) and BMI (0.64Ϯ1.6 kg/m 2 , pϭ0.006) whereas the participants without the Arg allele of the ADRB3 did not significantly change in these parameters (body weight: Ϫ0.36Ϯ4.2 kg, pϭ0.41; BMI: Ϫ0.24Ϯ1.5 kg/m 2 , pϭ0.12). The results in this study showed that the Arg allele of the ADRB3 is associated with long-term changes in body weight in obese individuals. This polymorphism may become an indicator in personalized weight loss programs in obese men.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

The Trp64Arg Polymorphism of the β3-adrenergic Receptor Gene is Associated with Weight Changes in obese Japanese Men: A 4-year Follow-up Study

Yamakita

Ando

Tang

et al. 2010

J Physiol Anthropol

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“…These results demonstrate that subjects carrying the Arg223 homozygous or Asn656 allele, which are closely linked to obesity, have relatively blunted leptin-mediated sympathetic nerve activity (observed as lower whole-body NE spillover) leading to lower thermogenesis, which may result in obesity (central obesity). Blunted leptin-mediated sympathetic nerve activity might play an important role in obesity, as we have previously reported (9,40). However, we could not discuss the relationship of leptin-receptor polymorphisms in thermogenesis or energy expenditure because we did not measure resting metabolic rates or energy expenditure in the present study.…”

Section: Discussionmentioning

confidence: 80%

Leptin-Receptor Polymorphisms Relate to Obesity through Blunted Leptin-Mediated Sympathetic Nerve Activation in a Caucasian Male Population

et al. 2008

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Leptin plays a key role in the regulation of body weight through the sympathetic nervous system; however, the contributions of leptin-receptor polymorphisms to obesity and sympathetic nerve activity have not been fully clarified. In the present study, we examined the relationships between leptin-receptor polymorphisms, plasma leptin and whole-body norepinephrine (NE) spillover as an index of sympathetic nerve activity in a Caucasian male cohort. In 129 young healthy normotensive men with a wide range of body mass index (BMI) (19.4-39.5 kg/m 2 ), we measured leptin-receptor polymorphisms (Gln223Arg, Lys656Asn, and Lys109Arg), plasma leptin levels, whole-body NE spillover, whole-body NE clearance, BMI and blood pressure (BP) levels in the supine position after overnight fasting. Overweight-obese (BMI≥25 kg/m 2 ) subjects had significantly greater BMI, BP levels, plasma leptin and whole-body NE spillover compared to lean (BMI <25 kg/m 2 ) subjects, but the NE clearance was similar. Overweight-obese subjects had significantly higher frequencies of the Arg223 allele and the Arg223 homozygous allele of Gln223Arg and the Asn656 allele of Lys656Asn compared to lean subjects. Subjects carrying the Arg223 homozygous or the Asn656 allele had higher levels of plasma leptin, BMI, waist circumference, and waist-to-hip ratio, but significantly less whole-body NE spillover, especially when they were also overweight-obese. BP levels and whole-body NE clearance were similar between subjects with and without the Arg223 homozygous or Asn656 allele. No differences were found in the distributions of the Arg109 allele of Lys109Arg polymorphism between nonobese and overweightobese subjects. In addition, BMI, BP, plasma leptin levels, whole-body NE spillover and whole-body NE clearance were similar between those with and without the Arg109 allele. Together, these findings demonstrate that leptin-receptor polymorphisms were related to the incidence of obesity in a Caucasian male population. These polymorphisms were accompanied by high plasma leptin levels (leptin resistance) and lower whole-body plasma NE spillover (blunted sympathetic nerve activity). We therefore hypothesize that leptin-receptor play a role in the development of obesity through leptin resistance and blunted leptin-mediated sympathetic nerve activity. (Hypertens Res 2008; 31: 1093-1100)

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“…We have also pointed out that leptin-receptor gene (LEPR) polymorphisms have a function in the development of obesity through leptin resistance and blunted leptin-mediated sympathetic nerve activity. 30 As the Gly16 allele of ADRB2 polymorphisms is linked to weight gain-induced BP elevation and is associated with leptin resistance, 31 the genotype information of adrenoceptors and leptin receptor gene polymorphisms may be useful for determining optimal diet and exercise.…”

Section: Genetic Basis For Hypertensionmentioning

confidence: 99%

Genetic basis of hypertension for the development of tailored medicine

et al. 2009

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Similar to a tsunami wave, a new surge of genome-wide association studies in common complex diseases has succeeded in identifying the causative genetic risk factors of hypertension. The current status of genomic studies in hypertension, however, remains disorganized, and there are no clear solutions in sight. One possible reason for this disorganization is the small effect of each genetic variant on the predisposition to hypertension. Another reason could be that the morbidity of hypertension is typically used as a target to assess genetic contribution, which could be resolved by introducing new technology into the classical genetic analysis. In this review, we reaffirm the genetic basis of hypertension and outline recent progress in genomics. In addition, we discuss both the possibility and usefulness of genomic information in the development of tailored medicine.

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.BETA.2- and .BETA.3-Adrenoceptor Polymorphisms Relate to Subsequent Weight Gain and Blood Pressure Elevation in Obese Normotensive Individuals

Cited by 41 publications

References 48 publications

The Trp64Arg Polymorphism of the β3-adrenergic Receptor Gene is Associated with Weight Changes in obese Japanese Men: A 4-year Follow-up Study

The Trp64Arg Polymorphism of the β3-adrenergic Receptor Gene is Associated with Weight Changes in obese Japanese Men: A 4-year Follow-up Study

Leptin-Receptor Polymorphisms Relate to Obesity through Blunted Leptin-Mediated Sympathetic Nerve Activation in a Caucasian Male Population

Genetic basis of hypertension for the development of tailored medicine

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