Beta-glucan from Saccharomyces cerevisiae reduces plasma lipid peroxidation induced by haloperidol

Dietrich‐Muszalska, Anna; Olas, Beata; Kontek, Bogdan; Rabe‐Jabłońska, Jolanta

doi:10.1016/j.ijbiomac.2011.03.007

Cited by 26 publications

(17 citation statements)

References 50 publications

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“…Supplementation with βG attenuated the increased level of MDA in tilapia exposed to ATZ, protecting the fish from lipid peroxidation and with increased SOD and CAT activities (Dietrich-Muszalska et al, 2011), as supported by SOD and CAT expression levels.…”

Section: Discussionmentioning

confidence: 72%

“…The increase in MDA levels in the ATZ group may be due to ATZ causing excess free radical production, promoting hepatic oxidative processes and aggravating a decrease in antioxidant enzyme by halting their production (Toughan et al, ). Supplementation with βG attenuated the increased level of MDA in tilapia exposed to ATZ, protecting the fish from lipid peroxidation and with increased SOD and CAT activities (Dietrich‐Muszalska et al, ), as supported by SOD and CAT expression levels.…”

Section: Discussionmentioning

confidence: 99%

“…The origin of β‐glucan is organic complex molecules which obtained from cereal and yeast species (Kaya, Ciftci, Cetin, Tecellioglu, & Basak, ). Previous studies have shown that β‐glucan has various activities, such as immunomodulation and anti‐oxidation (Dietrich‐Muszalska, Olas, Kontek, & Rabe‐Jablonska, ). As an example, β‐glucan protect DNA from oxidative damage by scavenging oxygen and hydroxyl radicals (Bashir & Choi, ).…”

Section: Introductionmentioning

confidence: 99%

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Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

2020

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Three hundred Oreochromis niloticus were divided into five groups; the control fish (CNT) were fed a basal diet, beta glucan (βG) group was fed 0.5 g/kg−1 βG, atrazine (ATZ) group was exposed to 1/5 96‐hr LC50 (1.39 mg/L) ATZ, the (βG/ATZ) group was fed βG while being exposed to ATZ, and the (βG then ATZ) group was supplemented with βG for fifteen days before exposed to ATZ. ATZ exposure caused a decline in growth that was ameliorated by βG. ATZ reduced the levels of total and different types of leucocytes. Additionally, ATZ exposure caused reductions in total proteins, globulins, α 1‐globulin, α 2‐globulin, ɤ‐globulin, immunoglobulin M, lysozymes, superoxide dismutase, nitric oxide and catalase but increases in hepatic transaminases and malondialdehyde without any variations in albumin and β‐globulin. Exposure to ATZ also resulted in a rise in the mRNA level of IL‐8. In contrast, expression of IgM, SOD and CAT were decreased in the tilapias exposed to ATZ. Exposure to ATZ increases the susceptibility response to Aeromonas sobria challenge, as indicated by an increase in cumulative mortality post‐challenge. Supplementation with βG fifteen days before (βG then ATZ group), counteracted the adverse effects of ATZ on the immune, biochemical and antioxidants values, though only slight alleviation was observed with simultaneous treatment (βG/ATZ group). Our results established that ATZ has adverse impacts on immune responses, antioxidant equilibrium and its related genes. While, supplementation with βG before exposure to ATZ may be valuable for counteracting the possible damage caused by ATZ water pollution than its simultaneous treatment with ATZ.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

2020

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“…β‐Glucans with polysaccharide structure are natural compounds derived from mushrooms, cereal species and yeast (Bayindir et al, ; Kaya et al, ). Previous research demonstrated that β‐glucans have many biological activities, such as antioxidation and immunomodulation (Dietrich‐Muszalska, Olas, Kontek, & Rabe‐Jabłońska, ). β‐Glucans protect the DNA from oxidative damage by scavenging the singlet oxygen or the hydroxyl radical (Bashir & Choi, ).…”

Section: Introductionmentioning

confidence: 99%

Favourable effect of β‐glucan treatment against cisplatin‐induced reproductive system damage in male rats

et al. 2019

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The aim of this study was to investigate the potential beneficial effects of β‐glucan treatment against oxidative, histological and spermatological damage caused by cisplatin on the male reproductive system. Twenty‐eight Sprague Dawley male rats were used in the study. The rats were randomly divided into four equal‐sized groups: a control group, cisplatin group (7 mg/kg in a single‐dose cisplatin administered intraperitoneally), β‐glucan group (β‐glucan given at a dose of 50 mg kg−1 d−1 for 14 day) and a cisplatin plus β‐glucan group (cisplatin and β‐glucan administered together at the same dose). Cisplatin administration induced an increase in the level of thiobarbituric acid‐reactive substances, a lipid peroxidation indicator. It induced a decrease in enzymatic (superoxide dismutase, catalase and glutathione peroxidase) activities and nonenzymatic (reduced glutathione) antioxidant levels. In addition, cisplatin caused both histological and spermatological damage, as shown by a decrease in sperm motility and epididymal sperm concentrations and an increase in abnormal sperm rates. The β‐glucan treatment improved cisplatin‐induced oxidative, histological and spermatological damage. This study revealed that β‐glucan treatment provided prevention against male reproductive system damage caused by cisplatin. These preventative effects were likely due to its antioxidant properties.

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“…Beta-glukan merupakan homopolimer glukosa yang diikat melalui ikatan ß-(1,3) dan ß-(1,6)-glukosida (Figueroa dan Stafollo, 2019) dan banyak ditemukan pada dinding sel beberapa bakteri, tumbuhan, dan khamir (Hunter et al, 2002). Salah satu khamir uniseluler yang tersebar luas di alam dan merupakan galur potensial penghasil beta-glukan adalah Saccharomyces cerevisiae, karena sebagian besar dinding selnya tersusun atas betaglukan (Lee et al, 2001;Dietrich-Muszalska et al, 2011;Li et al, 2018;Hong et al, 2019). Mikrobia ini bersifat nonpatogenik dan nontoksik, sehingga sejak dahulu banyak digunakan dalam berbagai proses fermentasi seperti pada pembuatan roti, asam laktat, dan alkohol (Lee, 1992).…”

Section: Kandungan Beta Glukanunclassified

Karakteristik Organoleptik Dan Kandungan Beta-Glukan Tempe Kedelai Dengan Penambahan Saccharomyces Cerevisiae

Rizal

Kustyawati

2019

JTP

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Kapang, R. oligosporus merupakan mikroba utama yang berperan dalam fermentasi tempe. Penambahan khamir selama fermentasi tempe mempengaruhi kandungan aroma tempe dan diduga menghasilkan beta-glukan dalam tempe. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan Saccharomyces cerevisiae terhadap sifat organoleptik dan kandungan betaglukan pada tempe. Perlakuan terdiri dari 2 faktor yaitu konsentrasi S. cerevisiae yang terdiri dari 1% dan 3%, perlakuan kedua adalah cara pemasakan terdiri dari 2 taraf yaitu tempe digoreng dan dikukus. Sebagai kontrol dilakukan pengamatan terhadap tempe mentah. Pengujian organoleptik, sampel tempe diambil 15 g lalu dimasak sesuai perlakuan kemudian diamati secara organoleptik dengan uji skoring menggunakan 25 orang panelis. Data dianalisis dengan sidik ragam untuk mendapat penduga ragam galat dan uji signifikansi untuk mengetahui pengaruh antar perlakuan. Perbedaan antar perlakuan dianalisis menggunakan Duncan Multiple Range Test (DMRT) pada taraf 5% untuk pengamatan terhadap sifat organoleptik tempe. Pengamatan sifat organoleptik dilakukan terhadap aroma langu, aroma khas tempe, rasa asam dan rasa pahit, dan penerimaan keseluruhan tempe. Hasil penelitian menunjukkan tempe yang dibuat dengan penambahan S. cerevisiae 1% dan digoreng memiliki sifat organoleptik terbaik, yakni aroma khas tempe, bau langu lebih rendah, tidak berasa asam, dan tidak pahit. Meskipun berdasarkan skor penerimaan keseluruhan organoleptik, tempe yang diberi penambahan S. cerevisiae 1% dan digoreng lebih disukai panelis dibandingkan perlakuan lainnya, akan tetapi, penambahan S. cerevisiae 3% menghasilkan tempe dengan kandungan beta-glukan lebih tinggi (0,250%) dibanding penambahan S. cerevisiae 1% (0,181%).

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Beta-glucan from Saccharomyces cerevisiae reduces plasma lipid peroxidation induced by haloperidol

Cited by 26 publications

References 50 publications

Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

Favourable effect of β‐glucan treatment against cisplatin‐induced reproductive system damage in male rats

Karakteristik Organoleptik Dan Kandungan Beta-Glukan Tempe Kedelai Dengan Penambahan Saccharomyces Cerevisiae

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