Beta-Lactams and Tetracyclines

Rose, Lucia; Peahota, Michelle M.; Gallagher, Jason C

doi:10.1016/bs.seda.2016.09.003

Cited by 3 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although less commonly found, another group of ARGs frequently detected was the tetracycline-resistance genes tetA and tetB , which are widely reported on the current clones that circulate worldwide. The extensive use of tetracyclines in veterinary and clinical settings as prophylactics and growth promoters may lead to the selective pressure for developing and disseminating those ARGs ( Rose et al, 2016 ; Samanta and Bandyopadhyay, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

Genomic insights of mcr-1 harboring Escherichia coli by geographical region and a One-Health perspective

Calero-Cáceres

Rodríguez²,

Medina³

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

The importance of the One Health concept in attempting to deal with the increasing levels of multidrug-resistant bacteria in both human and animal health is a challenge for the scientific community, policymakers, and the industry. The discovery of the plasmid-borne mobile colistin resistance (mcr) in 2015 poses a significant threat because of the ability of these plasmids to move between different bacterial species through horizontal gene transfer. In light of these findings, the World Health Organization (WHO) recommends that countries implement surveillance strategies to detect the presence of plasmid-mediated colistin-resistant microorganisms and take suitable measures to control and prevent their dissemination. Seven years later, ten different variants of the mcr gene (mcr-1 to mcr-10) have been detected worldwide in bacteria isolated from humans, animals, foods, the environment, and farms. However, the possible transmission mechanisms of the mcr gene among isolates from different geographical origins and sources are largely unknown. This article presents an analysis of whole-genome sequences of Escherichia coli that harbor mcr-1 gene from different origins (human, animal, food, or environment) and geographical location, to identify specific patterns related to virulence genes, plasmid content and antibiotic resistance genes, as well as their phylogeny and their distribution with their origin. In general, E. coli isolates that harbor mcr-1 showed a wide plethora of ARGs. Regarding the plasmid content, the highest concentration of plasmids was found in animal samples. In turn, Asia was the continent that led with the largest diversity and occurrence of these plasmids. Finally, about virulence genes, terC, gad, and traT represent the most frequent virulence genes detected. These findings highlight the relevance of analyzing the environmental settings as an integrative part of the surveillance programs to understand the origins and dissemination of antimicrobial resistance.

show abstract

Section: Resultsmentioning

confidence: 99%

Genomic insights of mcr-1 harboring Escherichia coli by geographical region and a One-Health perspective

Calero-Cáceres

Rodríguez²,

Medina³

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Antibiotics of this group are mostly not caused seriously symptoms. For example: nausea, vomiting, insomnia, abdominal pain and headache [47][48][49].…”

Section: Undesirable Effects Of Antibioticsmentioning

confidence: 99%

Quaternary ammonium chitin nanoparticles for antibacterial nanomedicine

Kumpanead

View full text Add to dashboard Cite

This research was purposed to synthesize quaternary ammonium chitin as an antibacterial agent for biomedical applications such as wound dressing, nanomedicine or drug carrier. (Carboxymethyl)trimethyl ammonium chloride (CMA) was selected to modified onto chitin (CT) via acylation resulted in carboxymethyl trimethyl ammonium chitin (CTCMA). CTCMA possessed positive charges to interact with negatively charged bacterial cell membrane, leading to cell death. In order to study the effect of material size and shape to antibacterial activity with an expectation that an increasing in surface area should enlarge positively charged exposure in a consequence of enhancing antibacterial activity, thus, CTCMA nanoparticles and hydrogels were fabricated in this research via ultra-sonication technique and self-assembly. From FTIR spectra, CTCMA exhibited the characteristic peak of ester linkage at 1735 cm-1 shifted from carboxylic ester of CMA at 1726 cm-1 and from 13C-NMR spectra, CTCMA exhibited the chemical shift of CH2- at 66.85 ppm and +NCH3 at 63.85 ppm, indicating the successful acylation. The degree of acylation or degree of substitution was determined as 1.67. Dynamic light scattering technique showed that particle size and surface charged of CTCMA were about 284.8±65.42 nm and 0.61±0.06, respectively. CTCMA was prepared into colloidal nanoparticles dispersed in distilled water and nanoparticles dried on glass slide. Besides, hydrogel was prepared via solvent exchange method. Antibacterial activity of samples was tested against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) by %reduction under ASTM E2149-10. It was found that CTCMA after fabrication into nanoparticles and hydrogels did not exhibited antibacterial activities. This might due to the hydrolysis of ester linkage during fabrication. Besides, the antibacterial activity of CTCMA nanoparticles dried on glass slide was also evaluated under AATCC100. It was found that CTCMA showed antibacterial activity against S. aureus around 14.62%. Degradation of CTCMA and CT hydrogels were investigated against lysozyme. CTCMA showed faster degradability than unmodified chitin. Explained from X-ray diffractogram of CTCMA, it represented crystallinity index about 68.79% which less than CT that represented about 82.94%. Thus, quaternary ammonium chitin could be applied for antibacterial biomedical applications. But, it has to be fabricated into ready to use applications instantly after synthesis for preserving its antibacterial activity.

show abstract