Beta radiation for glaucoma surgery

Kirwan, James; Rennie, Christina; Evans, Jennifer R

doi:10.1002/14651858.cd003433.pub3

Cited by 25 publications

(13 citation statements)

References 27 publications

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“…Numerous pharmacological strategies have been employed to modulate conjunctival scarring. These include corticosteroids [ 2 ], antimitotics (5-fluorouracil, 5-FU and mitomycin C, MMC) [ 3 – 5 ], beta-radiation [ 6 , 7 ], inhibitors of growth factors (lederlimumab, bevacizumab) [ 8 , 9 ], and metalloproteinase inhibitors (ilomastat) [ 10 ]. However, some of these drugs are relatively nonspecific and lead to complications such as hypotony, endophthalmitis, etc.…”

Section: Introductionmentioning

confidence: 99%

Custom RT-qPCR-array for glaucoma filtering surgery prognosis

Rodríguez-Agirretxe

García²,

Soria³

et al. 2017

PLoS ONE

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Excessive subconjunctival scarring is the main reason of failure of glaucoma filtration surgery. We analyzed conjunctival and systemic gene expression patterns after non penetrating deep sclerectomy (NPDS). To find expression patterns related to surgical failure and their correlation with the clinical outcomes. This study consisted of two consecutive stages. The first was a prospective analysis of wound-healing gene expression profile of six patients after NPDS. Conjunctival samples and peripheral blood samples were collected before and 15, 90,180, and 360 days after surgery. In the second stage, we conducted a retrospective analysis correlating the late conjunctival gene expression and the outcome of the NPDS for 11 patients. We developed a RT-qPCR Array for 88 key genes associated to wound healing. RT-qPCR Array analysis of conjunctiva samples showed statistically significant differences in 29/88 genes in the early stages after surgery, 20/88 genes between 90 and 180 days after surgery, and only 2/88 genes one year after surgery. In the blood samples, the most important changes occurred in 12/88 genes in the first 15 days after surgery. Correspondence analyses (COA) revealed significant differences between the expression of 20/88 genes in patients with surgical success and failure one year after surgery. Different expression patterns of mediators of the bleb wound healing were identified. Examination of such patterns might be used in surgery prognosis. RT-qPCR Array provides a powerful tool for investigation of differential gene expression wound healing after glaucoma surgery.

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Section: Introductionmentioning

confidence: 99%

Custom RT-qPCR-array for glaucoma filtering surgery prognosis

Rodríguez-Agirretxe

García²,

Soria³

et al. 2017

PLoS ONE

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“…Beta radiation can be delivered as a single, inexpensive, and timely controlled dose. A metaanalysis pooling four RCTs showed that patients who received trabeculectomy with beta radiation had a lower risk of surgical failure versus trabeculectomy alone [29]. More recently, Dhalla et al conducted a RCT directly comparing beta radiation with 5-FU as adjuncts to phacotrabeculectomy, which found no difference between the two arms in an African cohort [30], and there are studies underway comparing beta radiation to MMC in trabeculectomy.…”

Section: New Advances In Scarring Modulation Post Gfsmentioning

confidence: 99%

New therapeutic avenues in glaucoma surgery

Henein

Lee

Khaw

2018

Expert Review of Ophthalmology

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“…The application is rapid and simple, and includes controlling of both the dose and the area to be treated with accuracy. On the other hand, beta-radiation is especially attractive in the settings where regular drug supply and equipment maintenance are not available [3][4][5]. In a Cochrane review by Kirwan et al, investigating place of beta-radiation in glaucoma surgery including 4 randomized controlled study (RCT), people who had trabeculectomy with beta irradiation were found to have a lower risk of surgical failure compared to people who had trabeculectomy alone (pooled risk ratio (RR) 0.23 (95% CI 0.14 to 0.40).…”

Section: Introductionmentioning

confidence: 99%

“…The authors reported that increased risk of cataract was decreased with beta-irradiation (RR 2.89, 95% CI 1.39 to 6.0). They concluded that trabeculectomy with beta irradiation has a lower risk of surgical failure compared to trabeculectomy alone [5]. In a study by De Fendi et al, patients undergone trabeculectomy either with or without beta radiation were compared.…”

Section: Introductionmentioning

confidence: 99%

Place of beta-radiation in the etiology and treatment of cataract

Cihan¹

2018

Int J Clin Exp Ophthalmol

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Among eye diseases, cataract is the most commonly encountered lens disease and the leading cause of reduced vision. Cataract caused by radiation develops due to neck & head, central nervous system tumors, eye localized tumors and total body irradiation. Today, the only treatment of cataract is surgery.Beta radiation is seen to have an important place both in the etiology and treatment of cataract. Beta-radiation creates cataract in the lens as an adverse effect. However, beta radiation implementation is used for delay or prevention of cataract in glaucoma surgery. Effects of betaradiation on the etiology and treatment should be supported by further prospective clinical studies.

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Beta radiation for glaucoma surgery

Cited by 25 publications

References 27 publications

Custom RT-qPCR-array for glaucoma filtering surgery prognosis

Custom RT-qPCR-array for glaucoma filtering surgery prognosis

New therapeutic avenues in glaucoma surgery

Place of beta-radiation in the etiology and treatment of cataract

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