Betamethasone‐based chiral electrochemical sensor coupled to chemometric methods for determination of mandelic acid enantiomers

Abstract

A chiral biosensing platform was developed using betamethasone (BMZ) as chiral recognition element through multilayered electrochemical deposition of BMZ, overoxidized polypyrrole, and nanosheets of graphene (OPPy-BMZ/GR), for enantio-recognition of mandelic acid (MA) enantiomers. The deposited film was characterized by scanning electron microscopy, differential pulse voltammetry, cyclic voltammetry, and electrochemical impedance spectroscopy. It was shown that the chiral sensing platform can discriminate R- and S-MA differential pulse voltammetry signals, at the voltages of 1.35 and 1.33 V (vs Ag/AgCl), respectively. To tackle the problem of highly overlapping peaks of these enantiomers, the partial least squares (PLS) regression and genetic algorithm-PLS (GA-PLS) were used for simultaneous quantification of MA enantiomers. Generally, variable selection by genetic algorithm provided an improvement in prediction results when compared to full-voltammogram PLS. Good analytical performances were obtained despite the inherent complexity of the simultaneous determination.

Overoxidized polypyrrole/overoxidized poly(3,4-ethylenedioxythiophene)/graphene quantum dots-chitosan as enhanced electrochemical sensing platform for luteolin determination in peanut shells

“…It was conducive to interlayer diffusion of the responsive substance, thus increasing the effective specific area of the electrode. 22,26,34…”

“…It was conducive to interlayer diffusion of the responsive substance, thus increasing the effective specific area of the electrode. 22,26,34 3.4 Structural analysis 3.4.1 XPS analysis. As can be seen from Fig.…”

Chiral Graphene Hybrid Materials: Structures, Properties, and Chiral Applications

“…Jabbari and co‐workers developed a chiral biosensor using betamethasone as chiral selector through multilayered electrochemical deposition of betamethasone, overoxidized polypyrrole, and graphene sheets. [ 121 ] The chiral hybrid showed electrochemical enantiorecognition for mandelic acid enantiomers. Also for the purpose of electrochemical sensing, Kong et al.…”

“…Aside from amino acid and cyclodextrin, more and more other small chiral molecules are utilized for manufacturing chiral detecting material systems. [ 55,121,122 ] Mehdinia et al. developed a chiral sensor using betamethasone as chiral recognition element through a multilayered electrochemical deposition process, by which betamethasone, oxidized polypyrrole, and graphene sheets were deposited on the substrate.…”

“…developed a chiral sensor using betamethasone as chiral recognition element through a multilayered electrochemical deposition process, by which betamethasone, oxidized polypyrrole, and graphene sheets were deposited on the substrate. [ 121 ] The deposited chiral composite film recognized the enantiomers in racemic mandelic acid. Kong et al.…”