Betarezeptorenblocker

The mammalian clock and chronopharmacology

“…46,47 Many studies have shown that cardiovascular related events, such as myocardial infarction and stroke, often occur in the early morning due to circadian changes regulating blood pressure, heart rate, vasodilating hormones, etc. 47,48 Dihydropyridine calcium channel blockers, such as Norvasc, have been shown that time of day dosing, particularly evening, is the most advantageous for efficacy of the treatment and normalizing changes in blood pressure rhythms to reduce early morning cardiac events. 47,48 ACE inhibitors, AT-receptor blockers, diuretics, and other antihypertensives have also been studied to determine circadian-based time of day dosing for the most effective treatment.…”

“…47,48 Dihydropyridine calcium channel blockers, such as Norvasc, have been shown that time of day dosing, particularly evening, is the most advantageous for efficacy of the treatment and normalizing changes in blood pressure rhythms to reduce early morning cardiac events. 47,48 ACE inhibitors, AT-receptor blockers, diuretics, and other antihypertensives have also been studied to determine circadian-based time of day dosing for the most effective treatment.…”