Better outcome after pediatric defibrillation dosage than adult dosage in a swine model of pediatric ventricular fibrillation

Berg, Robert A.; Samson, Ricardo A.; Berg, Marc D.; Chapman, Fred W.; Hilwig, Ronald W.; Banville, Isabelle; Walker, Robert G.; Nova, Richard C.; Anavy, Nathan; Kern, Karl B.

doi:10.1016/j.jacc.2004.11.040

Cited by 77 publications

(36 citation statements)

References 15 publications

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“…(5) Biphasic shocks of high energy levels (360 J) are potentially harmful if used in low-weight small animals, as demonstrated in animal studies, (6,7) but not in humans. (8,9) Based on these fi ndings, it is reasonable to recommend that, based on the type of waveform used and the manufacturer's recommendations for the model of defi brillator, energy levels in the range of 120-200 J can be used to deliver the fi rst shock for VF.…”

Section: Defi Brillation Energymentioning

confidence: 99%

Singapore Defibrillation Guidelines 2016

Lee

Anantharaman

Lim

et al. 2017

smedj

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The most common initial rhythm in a sudden cardiac arrest is ventricular fi brillation or pulseless ventricular tachycardia. This is potentially treatable with defi brillation, especially if provided early. However, any delay in defi brillation will result in a decline in survival. Defi brillation requires coordination with the cardiopulmonary resuscitation component for effective resuscitation. These two components, which form the key links in the chain of survival, have to be brought to the cardiac victim in a timely fashion. An effective chain of survival is needed in both the institution and community settings.

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Section: Defi Brillation Energymentioning

confidence: 99%

Singapore Defibrillation Guidelines 2016

Lee

Anantharaman

Lim

et al. 2017

smedj

View full text Add to dashboard Cite

show abstract

“…Der AED soll mit einem Leistungsminderer ausgestattet sein, der die abgegebene Energie auf eine für Kinder im Alter von 1-8 Jahren besser geeignete Dosis reduziert (50-75 J; [317,323] …”

Section: Pad-/paddlegröße Für Die Defibrillationunclassified

Lebensrettende Maßnahmen bei Kindern („paediatric life support“)

Biarent

Bingham

Eich

et al. 2015

Notfall Rettungsmed

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“…A study by Berg et al 44 in 2003 compared a single escalating energy sequence (50,75, and 86 J) of an attenuated adult-dose biphasic shock, nonattenuated adult-dose biphasic shock, and weight-based monophasic shock for piglets with prolonged VF. The attenuated and monophasic dosages were delivered via pediatric pads and the nonattenuated dose was delivered via adult pads.…”

Section: Aed Energy and Waveform Safety And Efficacymentioning

confidence: 99%

“…In addition, the study indicated that the adult biphasic AED, although not as good as the attenuated dosage, was superior in outcome and LV ejection fraction to the weight-based monophasic AED. In another study, Berg et al 45 showed that escalating attenuated adult-dosage biphasic shocks are more effective and have fewer adverse outcomes than standard escalating adult-dosage biphasic shocks. Although the attenuated dosage was more effective and had fewer adverse effects on the myocardium, the adult escalatingdosage biphasic shocks also were effective in terminating VF in this piglet model of pediatric VF.…”

Section: Aed Energy and Waveform Safety And Efficacymentioning

confidence: 99%

See 1 more Smart Citation

Ventricular Fibrillation and the Use of Automated External Defibrillators on Children

Markenson¹,

Pyles²,

Neish³

et al. 2007

Pediatrics

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The use of automated external defibrillators (AEDs) has been advocated in recent years as a part of the chain of survival to improve outcomes for adult cardiac arrest victims. When AEDs first entered the market, they were not tested for pediatric usage and rhythm interpretation. In addition, the presumption was that children do not experience ventricular fibrillation, so they would not benefit from use of AEDs. Recent literature has shown that children do experience ventricular fibrillation, and this rhythm has a better outcome than do other cardiac arrest rhythms. At the same time, the arrhythmia software on AEDs has become more extensive and validated for children, and attenuation devices have become available to downregulate the energy delivered by AEDs to allow their use in children. Pediatricians are now being asked whether AED programs should be implemented, and where they are being implemented, pediatricians are being asked to provide guidance on the use of AEDs in children. As AED programs expand, pediatricians must advocate on behalf of children so that their needs are accounted for in these programs. For pediatricians to be able to provide guidance and ensure that children are included in AED programs, it is important for pediatricians to know how AEDs work, be up-to-date on the literature regarding pediatric fibrillation and energy delivery, and understand the role of AEDs as life-saving interventions for children.

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Better outcome after pediatric defibrillation dosage than adult dosage in a swine model of pediatric ventricular fibrillation

Abstract: In this model, pediatric shocks resulted in superior outcome compared with adult shocks. These data suggest that adult defibrillation dosing may be harmful to pediatric patients with VF and support the use of attenuating electrodes with adult biphasic AEDs to defibrillate children.

Cited by 77 publications

References 15 publications

Singapore Defibrillation Guidelines 2016

Singapore Defibrillation Guidelines 2016

Lebensrettende Maßnahmen bei Kindern („paediatric life support“)

Ventricular Fibrillation and the Use of Automated External Defibrillators on Children

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