Betuletol, a Propolis Component, Suppresses IL-33 Gene Expression and Effective against Eosinophilia

Shaha, Aurpita; Islam, Rezwanul; Tanaka, Naonobu; Kashiwada, Yoshiki; Fukui, Hirokazu; Takeda, Noriaki; Kitamura, Yoshiaki; Mizuguchi, Hiroyuki

doi:10.3390/molecules27175459

Cited by 3 publications

(1 citation statement)

References 48 publications

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“…Contact cheilitis has been reported in some patients and oral mucositis with ulceration in a patient who used propolis lozenges daily after dinner. This case report emphasizes the antigenic potential of propolis and suggests that it should be carefully used as a topical agent in the treatment of oral diseases [ 5 , 83 , 84 , 85 , 86 ]. Moreover, it highlights the fact that delayed propolis contact sensitivity should be taken into account in differential diagnosis of oral lesions.…”

Section: Role Of Propolis and Its Components In Allergymentioning

confidence: 97%

Allergic Inflammation: Effect of Propolis and Its Flavonoids

Oršolić

2022

Molecules

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The incidence of allergic diseases and their complications are increasing worldwide. Today, people increasingly use natural products, which has been termed a “return to nature”. Natural products with healing properties, especially those obtained from plants and bees, have been used in the prevention and treatment of numerous chronic diseases, including allergy and/or inflammation. Propolis is a multi-component resin rich in flavonoids, collected and transformed by honeybees from buds and plant wounds for the construction and adaptation of their nests. This article describes the current views regarding the possible mechanisms and multiple benefits of flavonoids in combating allergy and allergy-related complications. These benefits arise from flavonoid anti-allergic, anti-inflammatory, antioxidative, and wound healing activities and their effects on microbe-immune system interactions in developing host responses to different allergens. Finally, this article presents various aspects of allergy pathobiology and possible molecular approaches in their treatment. Possible mechanisms regarding the antiallergic action of propolis on the microbiota of the digestive and respiratory tracts and skin diseases as a method to selectively remove allergenic molecules by the process of bacterial biotransformation are also reported.

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Section: Role Of Propolis and Its Components In Allergymentioning

confidence: 97%

Allergic Inflammation: Effect of Propolis and Its Flavonoids

Oršolić

2022

Molecules

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Terpenoids, a Rising Star in Bioactive Constituents for Alleviating Food Allergy: A Review about the Potential Mechanism, Preparation, and Application

Hu,

Meng,

et al. 2024

J. Agric. Food Chem.

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Food allergies affect approximately 2.5% of the global population, with a notable increase in prevalence observed each year. Terpenoids, a class of natural bioactive constituents, have been widely utilized in the management of immune-and inflammation-related disorders, and their potential in alleviating food allergies is increasingly being recognized. This article summarizes various terpenoids derived from plant, fungal, and marine sources. Among them, triterpenoids, such as oleanolic acid, ursolic acid, and lupeol, possess the highest proportion and bioactivity in alleviating food allergy. Additionally, the mechanisms by which terpenoids may mitigate allergic diseases were categorically outlined, focusing on their roles in epithelial mucosal barrier function, immunomodulatory effects during the sensitization phase, inhibition of effector cells, oxidative stress, and regulation of microbial homeostasis. Finally, the advantages and limitations of natural extraction and artificial synthesis methods were compared, and the application of terpenoids in the food industry were also discussed. This article serves as a useful reference for the development of methods or functional foods based on terpenoids, which could represent a promising avenue for alleviating food allergy.

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The production, function, and clinical applications of IL-33 in type 2 inflammation-related respiratory diseases

Gu,

Wang,

Zhang

et al. 2024

Front. Immunol.

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Epithelial-derived IL-33 (Interleukin-33), as a member of alarm signals, is a chemical substance produced under harmful stimuli that can promote innate immunity and activate adaptive immune responses. Type 2 inflammation refers to inflammation primarily mediated by Type 2 helper T cells (Th2), Type 2 innate lymphoid cells (ILC2), and related cytokines. Type 2 inflammation manifests in various forms in the lungs, with diseases such as asthma and chronic obstructive pulmonary disease chronic obstructive pulmonary disease (COPD) closely associated with Type 2 inflammation. Recent research suggests that IL-33 has a promoting effect on Type 2 inflammation in the lungs and can be regarded as an alarm signal for Type 2 inflammation. This article provides an overview of the mechanisms and related targets of IL-33 in the development of lung diseases caused by Type 2 inflammation, and summarizes the associated treatment methods. Analyzing lung diseases from a new perspective through the alarm of Type 2 inflammation helps to gain a deeper understanding of the pathogenesis of these related lung diseases. This, in turn, facilitates a better understanding of the latest treatment methods and potential therapeutic targets for diseases, with the expectation that targeting lL-33 can propose new strategies for disease prevention.

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Betuletol, a Propolis Component, Suppresses IL-33 Gene Expression and Effective against Eosinophilia

Cited by 3 publications

References 48 publications

Allergic Inflammation: Effect of Propolis and Its Flavonoids

Allergic Inflammation: Effect of Propolis and Its Flavonoids

Terpenoids, a Rising Star in Bioactive Constituents for Alleviating Food Allergy: A Review about the Potential Mechanism, Preparation, and Application

The production, function, and clinical applications of IL-33 in type 2 inflammation-related respiratory diseases

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