Beyond babies: Implications of human genome editing for women, children, and families

Farrell, Ruth M.; Malek, Janet; Scott, Christopher Thomas

doi:10.1080/08989621.2021.1899824

Cited by 1 publication

(1 citation statement)

References 18 publications

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“…As the focus of the current debate has been on the safety of the child and its potential descendants, it has largely been ignored how i-HGE can also pose risks to the intended mother as she is the primary and first research subject exposed to the burdens of the experiments (Simonstein 2019 ; Farrell et al 2019 ; Farrell, Malek, and Scott 2021 ). It has also been noted in the literature that there are few safeguards to protect women.…”

Section: Mapping a Responsible Pathwaymentioning

confidence: 99%

Initial heritable genome editing: mapping a responsible pathway from basic research to the clinic

Ranisch

Trettenbach

Árnason

2022

Med Health Care and Philos

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Following the Second Summit on Human Gene Editing in Hong Kong in 2018, where the birth of two girls with germline genome editing was revealed, the need for a responsible pathway to the clinical application of human germline genome editing has been repeatedly emphasised. This paper aims to contribute to the ongoing discussion on research ethics issues in germline genome editing by exploring key issues related to the initial applications of CRISPR in reproductive medicine. Following an overview of the current discussion on bringing germline genome editing into clinical practice, we outline the specific challenges associated with such interventions and the features that distinguish them from conventional clinical testing of new medical treatments. We then review proposed ethical requirements for initial heritable genome editing, such as the absence of reasonable alternatives, the existence of sufficient and reliable preclinical data, appropriate informed consent, requirements related to safety, and long-term follow-up.

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Section: Mapping a Responsible Pathwaymentioning

confidence: 99%