Beyond cognition and sleep: Stop the domino effect

Abstract

Sleep problems, particularly sleep deprivation and fragmentations, are common hazards in modern lifestyles and maybe an unavoidable occupational drawback. Different metabolic or hereditary causes may induce sleep problems. Cognitive functions and the closely related metacognition, which depends significantly on decision making, are essential for learning and problem-solving. When impaired for any reason, the quality of life deteriorates, and the person may become dependent on others in severe cases of dysfunction. Sleep and cognition/metacognition are related, and an insult to one function may lead to the other domain's collapse. The present review highlights the significant causes and conditions of sleep problems, cognitive and metacognitive dysfunctions, the possible mechanisms, interactions, and the potential tools or agents that may improve them.

A systematic review of the neuropathology and memory decline induced by monosodium glutamate in the Alzheimer’s disease-like animal model

“…Noradrenergic dysfunction is a key factor in the prognosis of the disease. After discovering abnormalities in noradrenergic neurons in patients’ locus coeruleus, the noradrenaline involvement in this condition was first hypothesized ( AMIN et al, 2023 ). This has led to the hypothesis that cognitive dysfunctions and the development of neurodegeneration are caused by the early loss of noradrenergic projections and the consequent decline of the noradrenaline levels in the brain ( Rojas-Castañeda et al, 2016 ).…”