Beyond donation to organ utilization in the USA

Stewart, Darren; Lonze, Bonnie E.

doi:10.1097/mot.0000000000001060

Cited by 10 publications

(2 citation statements)

References 110 publications

(149 reference statements)

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“…For more than a decade, the increasing sizes of waiting lists have raised significant concerns, primarily due to the substantial imbalance in the number of potential donors 4 . Organs for transplantation primarily come from two sources: living donors (LD) and deceased donors (DD); it can be further categorized based on the type of death: death determined by circulatory criteria (DCC) and death determined by neurological criteria (DNC) 5 .…”

Section: Introductionmentioning

confidence: 99%

Critical pathway for deceased donors: An analysis in three regions of Colombia

Cruz-Mususú,

Orellano-Salas,

Vargas

et al. 2023

Rev Colomb Cir

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Introduction. The critical pathway for deceased donation offers a methodical framework for guiding the donation process. It not only serves to assess performance but also to identify areas of potential improvement. Therefore, the identification and selection of potential organ donors (POD) is a key process. This study aims to describe the critical pathway for deceased donation in a cohort of POD in three regions (CRT1, CRT2, and CRT5) of Colombia. Methods. We retrospectively reviewed data of POD assessed from January 2022 to December 2022. General characteristics of POD, diagnosis, contraindication causes, and organ procurement were described. Analysis was conducted using the Chi-squared test for categorical variables and the Mann-Whitney test for quantitative variables. Results. Within the cohort of 1451 assessed POD, 441 (30.3%) were diagnosed with brain death. Among potential donors after brain death, 198 (44.9%) were eligible donors (medically suitable). Of these, 157 donors (79.3%) became actual donors (undergoing operative incision for organ recovery), with 147 (96.3%) having at least one organ recovered (actual donors with organ recovery). Ultimately, 411 utilized organs were utilized. Additionally, there were observed differences in the characteristics of donors from different regions. Conclusion. This study reports the critical pathway for deceased donation in a cohort of POD in three regions of Colombia. This provides useful information and helps to gain insight and understanding into the process of organ donation and organ procurement in order to take actions that could improve the donation rates.

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Section: Introductionmentioning

confidence: 99%

Critical pathway for deceased donors: An analysis in three regions of Colombia

Cruz-Mususú,

Orellano-Salas,

Vargas

et al. 2023

Rev Colomb Cir

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“…However, shortage of organs remains an important obstacle. As a result, the disparity between the number of organ donors and patients awaiting transplantation continues to expand (4). Given the paucity of deceased donor organs, it is essential to optimize organ utilization practices (5,6).…”

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confidence: 99%

Understanding the dynamics of deceased organ donation and utilization in Colombia

Cruz Mususú,

García-Lopez,

Lozano-Suarez

et al. 2024

Revista Panamericana De Salud Pública

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Objective. To obtain a comprehensive overview of organ donation, organ utilization, and discard in the entire donation process in Colombia. Methods. A retrospective study of 1 451 possible donors, distributed in three regions of Colombia, evaluated in 2022. The general characteristics, diagnosis, and causes of contraindication for potential donors were described. Results. Among the 1 451 possible donors, 441 (30.4%) fulfilled brain death criteria, constituting the potential donors pool. Families consented to organ donation in 141 medically suitable cases, while 60 instances utilized legal presumption, leading to 201 eligible donors (13.9%). Of those, 160 (11.0%) were actual donors (in whom operative incision was made with the intent of organ recovery or who had at least one organ recovered). Finally, we identified 147 utilized donors (10.1%) (from whom at least one organ was transplanted). Statistically significant differences were found between age, sex, diagnosis of brain death, and donor critical pathway between regions. A total of 411 organs were transplanted from 147 utilized donors, with kidneys being the most frequently procured and transplanted organs, accounting for 280 (68.1%) of the total. This was followed by 85 livers (20.7%), 31 hearts (7.5%), 14 lungs (3.4%), and 1 pancreas (0.2%). The discard rate of procured deceased donors was 8.1%. Conclusions. About one-tenth of donors are effectively used for transplantation purposes. Our findings highlight areas of success and challenges, providing a basis for future improvements in Colombia.

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Novel Strategies for Optimization of the Pre-transplant Donor Lung

Hozain,

Jablonski

2024

Curr Pulmonol Rep

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Beyond donation to organ utilization in the USA

Cited by 10 publications

References 110 publications

Critical pathway for deceased donors: An analysis in three regions of Colombia

Critical pathway for deceased donors: An analysis in three regions of Colombia

Understanding the dynamics of deceased organ donation and utilization in Colombia

Novel Strategies for Optimization of the Pre-transplant Donor Lung

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