2023
DOI: 10.1016/j.resmic.2023.104087
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Beyond membrane components: uncovering the intriguing world of fungal sphingolipid synthesis and regulation

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Cited by 7 publications
(3 citation statements)
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“…It has been suggested that perhaps this specific glycosylation in fungi pathogenic to plants may help to protect fungal cells from plant defensin(s). It is not known if a similar effect is in place in fungi pathogenic to humans in protecting against human defensin(s) but it might be so because fungal mutants lacking these inositol-containing sphingolipids are highly susceptible to antimicrobial peptides [34]. As the methods for analyzing sphingolipids are improving, we are now beginning to decipher the complexity of their structure and their biological function (Fig 1).…”
Section: The De Novo Synthesis System Of Sphingolipidsmentioning
confidence: 99%
“…It has been suggested that perhaps this specific glycosylation in fungi pathogenic to plants may help to protect fungal cells from plant defensin(s). It is not known if a similar effect is in place in fungi pathogenic to humans in protecting against human defensin(s) but it might be so because fungal mutants lacking these inositol-containing sphingolipids are highly susceptible to antimicrobial peptides [34]. As the methods for analyzing sphingolipids are improving, we are now beginning to decipher the complexity of their structure and their biological function (Fig 1).…”
Section: The De Novo Synthesis System Of Sphingolipidsmentioning
confidence: 99%
“…Sphingolipids are ubiquitous and abundant components of eukaryotic plasma membranes and play multiple important roles in signal transduction, intracellular trafficking, apoptosis, cell differentiation, and other processes ( 3 , 4 ). Fungal sphingolipids play a pivotal role in growth, morphogenesis, and virulence and have potential as targets in future antifungal therapies ( 5 , 6 ). Fungi possess unique enzymes involved in the synthesis of fungal sphingolipids, which can produce lipids that are structurally different from their mammalian counterparts ( 5 ).…”
Section: Introductionmentioning
confidence: 99%
“…Most of the information available on fungal sphingolipid metabolism comes from the model organism Saccharomyces cerevisiae ( 7 , 8 ). Some details of the fungal sphingolipid metabolism of several filamentous fungi, such as Aspergillus , Cryptococcus , and Histoplasma , have also been described ( 6 , 9 13 ). Fungal glycosphingolipids are clustered along with sterols in specialized membrane microdomains termed lipid rafts, which play a crucial role in the establishment of fungal cell polarity ( 14 ).…”
Section: Introductionmentioning
confidence: 99%