Beyond Memory, Navigation, and Inhibition: Behavioral Evidence for Hippocampus-Dependent Cognitive Coordination in the Rat

Wesierska, M; Dockery, Colleen; Fenton, André A.

doi:10.1523/jneurosci.3962-04.2005

Cited by 146 publications

(162 citation statements)

References 49 publications

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“…2000; Kubik and Fenton 2005; Wesierska et al. 2005). Lesions in other brain regions such as the fornix or the anterior thalamus have also resulted in deficits in long‐term spatial memory (Aggleton et al.…”

Section: Discussionmentioning

confidence: 99%

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Early‐life single‐episode sevoflurane exposure impairs social behavior and cognition later in life

et al. 2016

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BackgroundSingle‐episode anesthetic exposure is the most prevalent surgery‐related incidence among young children in the United States. Although numerous studies have used animals to model the effects of neonatal anesthetics on behavioral changes later on in life, our understanding of the functional consequences to the developing brain in a comprehensive and clinically relevant manner is unclear.MethodsThe volatile anesthetic, sevoflurane (sevo) was administered to C57BL6 postnatal day 7 (P7) mice in a 40% oxygen and 60% nitrogen gas mixture. In order to examine the effects of sevo alone on the developing brain in a clinically relevant manner, mice were exposed to an average of 2.38 ± 0.11% sevo for 2 h. No sevo (control) mice were treated in an identical manner without sevo exposure. Mice were examined for cognition and neuropsychiatric‐like behavioral changes at 1–5 months of age.ResultsUsing the active place avoidance (APA) test and the novel object recognition (NOR) test, we demonstrated that P7 sevo‐treated mice showed a deficit in learning and memory both during periadolescence and adulthood. We then employed a battery of neuropsychiatric‐like behavioral tests to examine social interaction, communication, and repetitive behavior. Interestingly, compared to the no‐sevo–treated group, sevo‐treated mice showed significant reductions in the time interacting with a novel mouse (push–crawl and following), time and interaction in a chamber with a novel mouse, and time sniffing a novel social odor.ConclusionsOur study established that single‐episode, 2‐h sevo treatment during early life impairs cognition later on in life. With this approach, we also observed neuropsychiatric‐like behavior changes such as social interaction deficits in the sevo‐treated mice. This study elucidated the effects of a clinically relevant single‐episode sevo application, given during the neonatal period, on neurodevelopmental behavioral changes later on in life.

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Section: Discussionmentioning

confidence: 99%

“…1998; Wesierska et al. 2005). Two‐day trials were performed as described previously (Burghardt et al.…”

Section: Methodsmentioning

confidence: 99%

Early‐life single‐episode sevoflurane exposure impairs social behavior and cognition later in life

et al. 2016

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“…Fenton and colleagues have developed a rodent version of this task that can be used to study several crucial neurobiological and behavioural aspects of cognitive control (Wesierska, Dockery, and Fenton, 2005;O'Reilly et al, 2014). Rodents are exposed to two competing streams of information, only one of which must be used to avoid shock.…”

Section: Selective Attention and Cognitive Controlmentioning

confidence: 99%

On the functions, mechanisms, and malfunctions of intracortical contextual modulation

Phillips

Clark

Silverstein

2015

Neuroscience & Biobehavioral Reviews

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A broad neuron-centric conception of contextual modulation is reviewed and re-assessed in the light of recent neurobiological studies of amplification, suppression, and synchronization. Behavioural and computational studies of perceptual and higher cognitive functions that depend on these processes are outlined, and evidence that those functions and their neuronal mechanisms are impaired in schizophrenia is summarized. Finally, we compare and assess the long-term biological functions of contextual modulation at the level of computational theory as formalized by the theories of coherent infomax and free energy reduction. We conclude that those theories, together with the many empirical findings reviewed, show how contextual modulation at the neuronal level enables the cortex to flexibly adapt the use of its knowledge to current circumstances by amplifying and grouping relevant activities and by suppressing irrelevant activities.

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“…According to the distributed memory hypothesis, the minimum number of synapses needed to encode place avoidance memory was not available after the TTX injection. This account failed to explain why the same injections spared learning and retention when room and arena stimuli were not dissociated (Wesierska et al, 2005).…”

Section: Introductionmentioning

confidence: 96%

“…Acquisition, retrieval, and consolidation of the place response were abolished when room and arena stimuli were continuously dissociated by rotating the arena (Cimadevilla et al, 2001;Wesierska et al, 2005). According to the distributed memory hypothesis, the minimum number of synapses needed to encode place avoidance memory was not available after the TTX injection.…”

Section: Introductionmentioning

confidence: 99%

Behavioral Evidence That Segregation and Representation Are Dissociable Hippocampal Functions

Kubík¹,

Fenton²

2005

J. Neurosci.

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Hippocampal activity is thought to encode spatial representations in a distributed associative network. This idea predicts that partial hippocampal lesions would spare acquisition and impair retrieval of a place response as long as enough connections remained intact to encode associations. Water maze experiments supported the predictions, but the prediction of impaired retrieval was not supported when tetrodotoxin (TTX) was injected into one hippocampus and rats were tested in a place avoidance task on a rotating arena with shallow water. The rotation dissociated relevant distal stimuli from irrelevant self-motion stimuli. To explain the discrepancy, we hypothesized that the segregation of relevant and irrelevant stimuli and stimuli association into representations are distinct hippocampus-dependent operations, and whereas associative representation is more sensitive to disruption during retrieval than learning, stimulus segregation is more sensitive to disruption during learning than during retrieval. The following predictions were tested: (1) the TTX injection would spare learning but (2) impair retrieval of a place response in the water maze, which has a high associative representational demand but a low demand for segregation; (3) the injection would impair learning but (4) spare retrieval of place avoidance in the rotating arena filled with water, which has a high demand for stimulus segregation but a low associative representational demand. All four predictions were confirmed. The hypothesis also explains the pattern of sparing and impairment after the TTX injection in other place avoidance task variants, leading us to conclude that stimulus separation and association representation are dissociable functions of the hippocampus.

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Beyond Memory, Navigation, and Inhibition: Behavioral Evidence for Hippocampus-Dependent Cognitive Coordination in the Rat

Cited by 146 publications

References 49 publications

Early‐life single‐episode sevoflurane exposure impairs social behavior and cognition later in life

Early‐life single‐episode sevoflurane exposure impairs social behavior and cognition later in life

On the functions, mechanisms, and malfunctions of intracortical contextual modulation

Behavioral Evidence That Segregation and Representation Are Dissociable Hippocampal Functions

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