Beyond natural aromas: The bioactive and technological potential of monoterpenes

Paulino, Bruno Nicolau; Silva, Gloria Narjara Santos da; Araújo, Fábio Fernandes de; Numa, Iramaia Angélica Neri; Pastore, Gláucia Maria; Bicas, Juliano Lemos

doi:10.1016/j.tifs.2022.08.006

Cited by 37 publications

(16 citation statements)

References 154 publications

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“…Monoterpenes are hydrocarbons with a wide molecular range commonly used as flavoring agents in the cosmetics, pharmaceutical, and food industries [13]. In addition, several biological properties have been attributed to these compounds including analgesic, anti-inflammatory, anticonvulsant, antidepressant, anti-Alz-heimerʼs, anti-Parkinsonʼs, and antimicrobial effects [14], among others.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, several biological properties have been attributed to these compounds including analgesic, anti-inflammatory, anticonvulsant, antidepressant, anti-Alz-heimerʼs, anti-Parkinsonʼs, and antimicrobial effects [14], among others. The antimicrobial and antioxidant potential of monoterpenes can be determined by certain structural characteristics such as the presence of hydroxyl groups and the number of double bonds (acyclic monoterpenes), conjugated double bonds, and phenolic groups (monocyclic monoterpenes) and carbonyl groups constituting aldehydes or ketones (bicyclic monoterpene) [13].…”

Section: Resultsmentioning

confidence: 99%

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Synergism Between Essential Oils and Evaluation of Their Activities with a Focus on Malassezia furfur Control

Cassola,

Ramírez,

Ribeiro

et al. 2023

Planta Med

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Seborrheic dermatitis is a chronic inflammatory disease caused by Malassezia yeast species that affects the regions of the body where the sebaceous glands are present. The combined use of different essential oils (EOs) can increase their spectrum of action. Thus, the present study aimed to evaluate the action of EOs alone and in combination with each other on M. furfur, in planktonic and biofilm form, and their anti-inflammatory and mutagenic potential, in addition to the effects on the viability of cells lines. Of the 40 evaluated EOs, 22 showed activity against M. furfur at 0.5 – 2.0 mg/mL concentrations. Among the most active species, a blend of essential oils (BEOs) composed of Cymbopogon martini (Roxb.) Will. Watson (MIC = 0.5 mg/mL) and Mentha × piperita L. (MIC = 1.0 mg/mL) was selected, which showed a synergistic effect against yeast when evaluated through the checkerboard assay. The fungicidal activity was maintained by the addition of anti-inflammatory oil from Varronia curassavica Jacq. to BEOs. The BEOs also showed activity in the inhibition of biofilm formation and in the eradication of the biofilm formed by M. furfur, being superior to the action of fluconazole. Furthermore, it did not show mutagenic potential and did not interfere with the cell viability of both evaluated cell lines (HaCaT and BMDMs). TNF-α levels were reduced only by C. martini; however, this property was maintained when evaluating BEOs. BEOs had no effect on IL-8 levels. Thus, the BEOs may be indicated for alternative treatments against seborrheic dermatitis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Synergism Between Essential Oils and Evaluation of Their Activities with a Focus on Malassezia furfur Control

Cassola,

Ramírez,

Ribeiro

et al. 2023

Planta Med

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show abstract

“…Isoprene emissions from plants play important roles in plant defenses against biotic and abiotic stresses, and they can also improve photosynthetic performance at high temperatures [ 118 , 119 , 120 ]. Monoterpenes are essential substances in the aromatic oil, cosmetic, perfume, food, and pharmaceutical industries for their unique odors [ 121 , 122 , 123 ]. While monoterpene synthases (mTPSs) are considered to catalyze GPP for monoterpenes, the GPP transporter has not yet been discovered [ 111 ].…”

Section: Biosynthesis Pathways Of Terpenoidsmentioning

confidence: 99%

Biosynthesis and the Transcriptional Regulation of Terpenoids in Tea Plants (Camellia sinensis)

Wei

Yang

et al. 2023

IJMS

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Terpenes, especially volatile terpenes, are important components of tea aroma due to their unique scents. They are also widely used in the cosmetic and medical industries. In addition, terpene emission can be induced by herbivory, wounding, light, low temperature, and other stress conditions, leading to plant defense responses and plant–plant interactions. The transcriptional levels of important core genes (including HMGR, DXS, and TPS) involved in terpenoid biosynthesis are up- or downregulated by the MYB, MYC, NAC, ERF, WRKY, and bHLH transcription factors. These regulators can bind to corresponding cis-elements in the promoter regions of the corresponding genes, and some of them interact with other transcription factors to form a complex. Recently, several key terpene synthesis genes and important transcription factors involved in terpene biosynthesis have been isolated and functionally identified from tea plants. In this work, we focus on the research progress on the transcriptional regulation of terpenes in tea plants (Camellia sinensis) and thoroughly detail the biosynthesis of terpene compounds, the terpene biosynthesis-related genes, the transcription factors involved in terpene biosynthesis, and their importance. Furthermore, we review the potential strategies used in studying the specific transcriptional regulation functions of candidate transcription factors that have been discriminated to date.

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“…The antioxidant activity of essential oils is closely related to the chemical structure of terpenoids, such as the benzene ring linking to hydroxyl groups and the double bonds, providing a greater ability to eliminate free radicals [ 15 ]. In addition to the common chemical assays, such as 1,1-Diphenyl-2-(2,4,6-trinitrophenyl)diazen-1-ium (DPPH) and 2,2’-Azinobis-(3-ethylbenzthiazoline-6-sulphonate (ABTS) assays, free radical scavenging experiments at the cellular level can more authentically reflect the effects of natural products on human health.…”

Section: Introductionmentioning

confidence: 99%

Screening of Rosemary Essential Oils with Different Phytochemicals for Antioxidant Capacity, Keratinocyte Cytotoxicity, and Anti-Proliferative Activity

Huang

Ding

et al. 2023

Molecules

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Nowadays, the demand for rosemary essential oils (REOs) in the cosmetic, food, and pharmaceutical industries is increasing, and the abundant germplasm resources of rosemary provide more possibilities for functional applications. The REOs from six cultivars were selected to evaluate and compare their bioactivities. REOs have good cellular antioxidant activity in scavenging reactive oxygen species, and the technology for order preference by similarity to an ideal solution (TOPSIS)-random forest multivariate model indicated that ‘Dutch Mill’ REO has the best antioxidant activity, which is closely related to its verbenone content. In addition, α-pinene-dominant REOs are more toxic to human keratinocytes, which is closely related to the content of α-pinene, as revealed by multivariate analyses. Moreover, anti-proliferative assays on six cancer cell lines showed that all REOs have a higher anti-proliferative ability against human pancreatic cancer cell line SW1990 and gastric epithelial cell line NCI-N87. Among them, ‘Miss Jessopp’s Upright’ and ‘Blue Lagoon’ REOs exhibit more prominent anti-proliferative activity. Our study provides a reference value for exploring the application potential of different REOs by evaluating their differences in chemical composition and bioactivity.

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Beyond natural aromas: The bioactive and technological potential of monoterpenes

Cited by 37 publications

References 154 publications

Synergism Between Essential Oils and Evaluation of Their Activities with a Focus on Malassezia furfur Control

Synergism Between Essential Oils and Evaluation of Their Activities with a Focus on Malassezia furfur Control

Biosynthesis and the Transcriptional Regulation of Terpenoids in Tea Plants (Camellia sinensis)

Screening of Rosemary Essential Oils with Different Phytochemicals for Antioxidant Capacity, Keratinocyte Cytotoxicity, and Anti-Proliferative Activity

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