Beyond silent hypoxemia: Does COVID‐19 can blunt pain perception? Comment on “The neuroinvasive potential of SARS CoV2 may play a role in the respiratory failure of COVID 19 patients”

Coen, Matteo; Kaiser, C.; Naimi, Roxane; Uginet, Marjolaine; Hentsch, Lisa; Serratrice, Jacques; Allali, Gilles

doi:10.1002/jmv.26753

Cited by 7 publications

(11 citation statements)

References 11 publications

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“…Finally, although reports have shown that patients are at risk of developing chronic pain in the post-COVID-19 phase [ 93 , 94 ], it has been recently suggested that acute SARS-CoV-2 infection may reduce nociceptive pain perception [ 95 ]. Indeed, although evidence is still lacking at this stage, SARS-CoV-2 has been shown to inhibit neuropathic pain signalling by binding to neuroliptin-1 receptors on sensory neurones in animal models [ 96 ].…”

Section: Perspectives and Research Opportunitiesmentioning

confidence: 99%

Breathlessness and COVID-19: A Call for Research

Hentsch

Cocetta²,

Allali

et al. 2021

Respiration

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Breathlessness, also known as dyspnoea, is a debilitating and frequent symptom. Several reports have highlighted the lack of dyspnoea in a subgroup of patients suffering from COVID-19, sometimes referred to as “silent” or “happy hypoxaemia.” Reports have also mentioned the absence of a clear relationship between the clinical severity of the disease and levels of breathlessness reported by patients. The cerebral complications of COVID-19 have been largely demonstrated with a high prevalence of an acute encephalopathy that could possibly affect the processing of afferent signals or top-down modulation of breathlessness signals. In this review, we aim to highlight the mechanisms involved in breathlessness and summarize the pathophysiology of COVID-19 and its known effects on the brain-lung interaction. We then offer hypotheses for the alteration of breathlessness perception in COVID-19 patients and suggest ways of further researching this phenomenon.

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Section: Perspectives and Research Opportunitiesmentioning

confidence: 99%

Breathlessness and COVID-19: A Call for Research

Hentsch

Cocetta²,

Allali

et al. 2021

Respiration

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“…When all three criteria are met, a diagnosis of LE can be made. Therefore, analyzed studies [10,21,23,25,32] show that para-infectious LE, associated with SARS-CoV-2, can be considered as an independent disease, which should be studied more because the possible consequences for patients and society are unclear, while the frequency and prognosis of this disease still need to be clarified. Interestingly, it is possible for para-infectious LE, associated with SARS-CoV-2 to occur in patients with respiratory system involvement, as well as in patients with no respiratory symptoms [10], including single cases of isolated attack on the limbic system [20].…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, it is possible for para-infectious LE, associated with SARS-CoV-2 to occur in patients with respiratory system involvement, as well as in patients with no respiratory symptoms [10], including single cases of isolated attack on the limbic system [20]. In the majority of described clinical cases, the most common neurological symptoms of this disease were: cognitive impairment; focal and generalized tonic-clonic seizures, including the development of status epilepticus; neuropsychiatric symptoms (olfactory and visual hallucinations, short-term memory loss, anxiety-depressive disorders, socialization problems); and olfactory dysfunction [10,21,23,25,32]. The presence of ictal or (more common) interictal abnormal activity located in the temporal lobe in electroencephalography (EEG) should be considered as a significant factor [13].…”

Section: Discussionmentioning

confidence: 99%

“…Damage to the insula can cause the impairment of gustatory perception (dysgeusia and ageusia), changes in emotional behavior (apathy, increased anxiety, decreased empathy) and memory impairment [31]. As for features accompanying changes in this region in COVID-19 patients, some case reports describe possible courses presenting disturbances in pain perception and interoception [32].…”

Section: Neuroanatomy Of Limbic System and Covid-19mentioning

confidence: 99%

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Limbic Encephalitis Associated with COVID-19

et al. 2021

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Limbic encephalitis (LE) is an inflammatory disease of the brain, in which lesion is anatomically limited in structures of the limbic system. In some cases, LE can start with symptoms of limbic dysfunction with further involvement of other regions of the brain. Classic LE syndrome includes such symptoms as the development of personality disorders, depression, sleep disorders, epileptic seizures, hallucinations and cognitive disorders (short-term and long-term memory impairment). The information of clinical examination, electroencephalogram (EEG), magnetic resonance imaging (MRI) and cerebrospinal fluid studies (CSF) suggest the diagnosis of LE in most patients with Coronavirus Disease 2019 (COVID-19).

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“…Obwohl sich in Berichten gezeigt hat, dass für Patienten in der Post-COVID-19-Phase die Gefahr einer Entwicklung chronischer Schmerzen besteht [ 93 , 94 ], wurde kürzlich darauf hingewiesen, dass eine akute SARS-CoV-2-Infektion die nozizeptive Schmerzwahrnehmung reduzieren kann [ 95 ]. Obwohl die Evidenz in diesem Stadium noch mangelhaft ist, hat sich gezeigt, dass SARS-CoV-2 in Tiermodellen die neuropathischen Schmerzsignale durch Bindung an Neuroliptin-1-Rezeptoren auf sensorischen Neuronen hemmt [ 96 ].…”

Section: Perspektiven Und Forschungsmöglichkeitenunclassified

Atemnot und COVID-19: Ein Aufruf zu mehr Forschung

Hentsch¹,

Cocetta²,

Allali

et al. 2022

Kompass Pneumol

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Atemnot, auch als Dyspnoe bezeichnet, ist ein häufiges und lähmendes Symptom. In mehreren Berichten wurde die Abwesenheit von Atemnot bei einer Untergruppe von Patienten mit COVID-19 hervorgehoben, die manchmal als «stille» oder «glückliche Hypoxie» bezeichnet wird. Ebenfalls wurde in Berichten erwähnt, dass es an einem klaren Zusammenhang zwischen dem klinischen Schweregrad der Erkrankung und der von den Patienten berichteten Schwere der Atemnot fehlt. Die zerebralen Komplikationen von COVID-19 sind weitgehend nachgewiesen, mit einer hohen Prävalenz akuter Enzephalopathien, die möglicherweise die Verarbeitung afferenter Signale oder die absteigende Modulation von Atemnotsignalen beeinträchtigen könnte. In dieser Übersichtsarbeit möchten wir die an der Atemnot beteiligten Mechanismen hervorheben und die Pathophysiologie von COVID-19 und den bekannten Auswirkungen der Erkrankung auf die Interaktion von Gehirn und Lunge zusammenfassen. Anschließend stellen wir Hypothesen für die Veränderung der Wahrnehmung von Atemnot bei COVID-19-Patienten auf und schlagen Möglichkeiten vor, mit denen dieses Phänomen weiter erforscht werden könnte.

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Beyond silent hypoxemia: Does COVID‐19 can blunt pain perception? Comment on “The neuroinvasive potential of SARS CoV2 may play a role in the respiratory failure of COVID 19 patients”

Cited by 7 publications

References 11 publications

Breathlessness and COVID-19: A Call for Research

Breathlessness and COVID-19: A Call for Research

Limbic Encephalitis Associated with COVID-19

Atemnot und COVID-19: Ein Aufruf zu mehr Forschung

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