Beyond soluble transferrin receptor: Old challenges and new horizons

Harms, Kristian; Kaiser, Thorsten

doi:10.1016/j.beem.2015.09.003

Cited by 49 publications

(43 citation statements)

References 86 publications

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“…In addition, the vast majority of the existing literature centres on serum ferritin as a biomarker of iron stores. Ferritin levels, however, may not be the optimal indicator of iron status, as they may also increase in the presence of infection or inflammation [13]. Alternatively, soluble transferrin receptor (sTfR), a marker of tissue iron insufficiency, could provide useful and complementary information on iron status as it is considered to be less influenced by the acute-phase response than ferritin [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

A longitudinal study of iron status during pregnancy and the risk of gestational diabetes: findings from a prospective, multiracial cohort

et al. 2016

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Aims/hypothesis The aim of this study was to prospectively and longitudinally investigate maternal iron status during early to mid-pregnancy, and subsequent risk of gestational diabetes mellitus (GDM), using a comprehensive panel of conventional and novel iron biomarkers. Methods A case-control study of 107 women with GDM and 214 controls (matched on age, race/ethnicity and gestational week during blood collection) was conducted within the the Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth Studies-Singleton Cohort (2009)(2010)(2011)(2012)(2013), a prospective and multiracial pregnancy cohort. Plasma hepcidin, ferritin and soluble transferrin receptor (sTfR) were measured and sTfR:ferritin ratio was derived, twice before GDM diagnosis (gestational weeks 10-14 and 15-26) and at weeks 23-31 and 33-39. GDM diagnosis was ascertained from medical records. Adjusted ORs (aORs) for GDM were estimated using conditional logistic regression analysis, adjusting for demographics, prepregnancy BMI and other major risk factors. Results Hepcidin concentrations during weeks 15-26 were 16% higher among women with GDM vs controls (median 6.4 vs 5.5 ng/ml; p = 0.02 ), and were positively associated with GDM risk; the aOR (95% CI) for highest vs lowest quartile was 2.61 (1.07, 6.36). Ferritin levels were also positively associated with GDM risk; the aOR (95% CI) for highest vs lowest quartile was 2.43 (1.12, 5.28) at weeks 10-14 and 3.95 (1.38, 11.30) at weeks 15-26. The sTfR:ferritin ratio was inversely related to GDM risk; the aOR (95% CI) for highest vs lowest quartile was 0.33 (0.14, 0.80) at weeks 10-14 and 0.15 (0.05, 0.48) at weeks 15-26. Conclusions/interpretation Our findings suggest that elevated iron stores may be involved in the development of GDM from as early as the first trimester. This raises potential concerns for the recommendation of routine iron supplementation among iron-replete pregnant women.

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Section: Introductionmentioning

confidence: 99%

A longitudinal study of iron status during pregnancy and the risk of gestational diabetes: findings from a prospective, multiracial cohort

et al. 2016

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“…17 La cantidad de receptores tisulares, en su mayoría células eritroides, determina la cantidad de RST. 18 La concentración plasmática de RST refleja la densidad del receptor en las células y la cantidad de células que expresan el receptor; también está estrechamente relacionada con las demandas celulares de hierro y la tasa de proliferación de células eritroides. 17 El valor de RST aumenta a medida que disminuyen los niveles celulares de hierro, 15 no se ve afectado por la inflamación y es adecuado para supervisar la respuesta eritropoyética al tratamiento de la AF con hierro.…”

Section: Introductionunclassified

“…17 El valor de RST aumenta a medida que disminuyen los niveles celulares de hierro, 15 no se ve afectado por la inflamación y es adecuado para supervisar la respuesta eritropoyética al tratamiento de la AF con hierro. [18][19][20][21] Hasta el momento, no se han realizado estudios que se centren en el uso del RST en el diagnóstico diferencial de la AF en niños con desnutrición. nuestro objetivo era evaluar la eficacia del RST para detectar la AF y examinar la respuesta al tratamiento con hierro en los lactantes con DAM, además de determinar si es superior a los marcadores tradicionales de la AF en estos pacientes.…”

Section: Introductionunclassified

¿Puede usarse el receptor soluble de transferrina para diagnosticar anemia ferropénica y evaluar la respuesta al hierro en lactantes con desnutrición aguda moderada?

Büyükkaragöz

Buluş

et al. 2017

Arch Argent Pediat

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RESUMENObjetivo. Evaluar la eficacia del receptor soluble de transferrina (RST) en el diagnóstico de la anemia ferropénica (AF) y en la evaluación de la respuesta al hierro en los lactantes con desnutrición aguda moderada (DAM). Población y métodos. Se reclutó a lactantes con valores de hemoglobina (Hb) inferiores a los valores umbrales de anemia para su edad y con anemia hipocrómica/microcítica observada en el frotis de sangre periférica. La DAM se definió como un puntaje Z de peso/estatura de entre < -2 y -3. Se compararon los valores del hemograma, los parámetros férricos y el RST entre 41 lactantes con DAM y anemia (grupo DA), 32 lactantes con anemia sin DAM (grupo A) y controles saludables (n= 30). Una vez completado el tratamiento de la anemia y la desnutrición, se repitieron las evaluaciones. Resultados. Además de los índices hematológicos compatibles con AF, los valores de hierro sérico (Fe) y saturación de transferrina (ST) eran significativamente menores, mientras que el valor de transferrina era significativamente mayor en los grupos DA y A en comparación con los controles (p < 0,001). Los valores de ferritina y proteína C-reactiva (PCR) eran significativamente más elevados en el grupo DA (p < 0,05 para la ferritina, p < 0,01 para la PCR). El valor medio del RST fue similar en ambos grupos (DA y A) (p > 0,05) y significativamente mayor que en los controles (p < 0,001). Después del tratamiento con hierro, el RST disminuyó en los grupos DA y A (p < 0,001) a valores similares a los observados en los controles. El RST se correlacionó negativamente con la Hb durante todo el estudio (grupo DA: r= -0,350, p < 0,05; grupo A: r= -0,683, p < 0,01). Conclusiones. Dado que los valores del RST en los grupos DA y A disminuyeron después del tratamiento con hierro, consideramos que este parámetro no estuvo afectado por la DAM ni la inflamación y puede usarse, por sí solo, para detectar la AF y supervisar la respuesta al tratamiento en los lactantes con DAM. INTRODUCCIÓNLa desnutrición por carencias energéticas y proteínicas se manifiesta principalmente por una ingesta inadecuada de proteínas y calorías.1 Es un problema de salud muy importante en los países en vías de desarrollo, y está asociada con el 50% al 60% de la mortalidad en menores de 5 años en estos entornos.2 Además de causar retraso del crecimiento, emaciación y peso insuficiente, las deficiencias de micronutrientes, en especial de vitaminas y minerales, también son componentes importantes de la desnutrición por carencias energéticas y proteínicas.1,3,4 La ferropenia es la carencia nutricional más frecuente en todo el mundo; además, se observan anemia por inflamación y AF en los niños con desnutrición. [4][5][6] En la actualidad, las pruebas tradicionales para el diagnóstico de la AF no bastan.7 Si se usan por separado, ninguna es lo suficientemente sensible o específica como para diagnosticar la AF. Por un lado, la sensibilidad del volumen corpuscular medio (VCM) es baja; por el otro, la ST y la capacidad total de fijación del hierro (CTFH) tienen una ba...

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“…17 The number of tissue receptors, mostly on erythroid cells, determines the Original article number of sTfR. 18 Plasma sTfR concentration reflects the receptor density on cells and the number of cells expressing the receptor; and is closely related to cellular iron demands and erythroid proliferation rate. 17 sTfR level increases parallel to the decrease in cellular iron levels, 15 is not affected from inflammation, and suitable for monitoring erythropoietic response to treatment of IDA with iron.…”

Section: Introductionmentioning

confidence: 99%

“…17 sTfR level increases parallel to the decrease in cellular iron levels, 15 is not affected from inflammation, and suitable for monitoring erythropoietic response to treatment of IDA with iron. [18][19][20][21] Up to date, no studies focused on the use of sTfR in the differential diagnosis of IDA in children with malnutrition. Our aim was to evaluate the efficacy of sTfR in detecting IDA and to assess the response to iron treatment in infants with MAM; and determine whether it has any superiority to classical markers of IDA in these patients.…”

Section: Introductionmentioning

confidence: 99%

Can soluble transferrin receptor be used in diagnosing iron deficiency anemia and assessing iron response in infants with moderate acute malnutrition?

Büyükkaragöz

Buluş

et al. 2017

Arch Argent Pediat

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Objective. To evaluate the efficacy of soluble transferrin receptor (sTfR) in diagnosing iron deficiency anemia (IDA) and evaluating iron response in infants with moderate acute malnutrition (MAM). Population and methods. Infants with hemoglobin (Hb) levels lower than threshold values for anemia for their ages and hypochromic/ microcytic anemia on peripheral smear were recruited. MAM was defined as weight/height z score < -2 to -3. Complete blood count (CBC), iron parameters and sTfR were compared among 41 infants with MAM and anemia (MA group), 32 infants with anemia without MAM (group A), and healthy controls (n= 30). Following anemia and malnutrition treatment, tests were repeated. Results. Besides hematological indices compatible with IDA, serum iron (Fe) and transferrin saturation (TS) were significantly lower, while transferrin was significantly higher in MA and A groups compared to controls (p <0.001). Ferritin and C-reactive protein (CRP) were significantly higher in MA group (p <0.05 ferritin, p <0.01 for CRP). Mean sTfR was similar in both MA and A groups (p >0.05) and significantly higher than controls (p <0.001). Following iron treatment, sTfR decreased in both MA and A groups (p <0.001) to similar values as controls. sTfR was negatively correlated to Hb throughout the study (for MA group, r= -0.350, p <0.05; for A group, r= -0.683, p <0.01). Conclusions.As sTfR values in both MA and A groups decreased following iron treatment, we believe that this parameter was not influenced by MAM or inflammation; and it alone can be used to detect IDA and monitor treatment response in infants with MAM.

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Beyond soluble transferrin receptor: Old challenges and new horizons

Cited by 49 publications

References 86 publications

A longitudinal study of iron status during pregnancy and the risk of gestational diabetes: findings from a prospective, multiracial cohort

A longitudinal study of iron status during pregnancy and the risk of gestational diabetes: findings from a prospective, multiracial cohort

¿Puede usarse el receptor soluble de transferrina para diagnosticar anemia ferropénica y evaluar la respuesta al hierro en lactantes con desnutrición aguda moderada?

Can soluble transferrin receptor be used in diagnosing iron deficiency anemia and assessing iron response in infants with moderate acute malnutrition?

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