Beyond speciation genes: an overview of genome stability in evolution and speciation

Dion-Côté, Anne-Marie; Barbash, Daniel A.

doi:10.1016/j.gde.2017.07.014

Cited by 65 publications

(50 citation statements)

References 73 publications

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“…SatDNA repeats are seen as prime candidates to trigger genome instability in interspecies hybrids [71]. They have been implicated in disruption of chromosome pairing, abnormal heterochromatin packaging, and selfish post-meiotic drive substitutions in Drosophila hybrids [67].…”

Section: Discussionmentioning

confidence: 99%

Structural Variation of the X Chromosome Heterochromatin in the Anopheles gambiae Complex

Sharma

Kinney

Timoshevskiy

et al. 2020

Genes

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Heterochromatin is identified as a potential factor driving diversification of species. To understand the magnitude of heterochromatin variation within the Anopheles gambiae complex of malaria mosquitoes, we analyzed metaphase chromosomes in An. arabiensis, An. coluzzii, An. gambiae, An. merus, and An. quadriannulatus. Using fluorescence in situ hybridization (FISH) with ribosomal DNA (rDNA), a highly repetitive fraction of DNA, and heterochromatic Bacterial Artificial Chromosome (BAC) clones, we established the correspondence of pericentric heterochromatin between the metaphase and polytene X chromosomes of An. gambiae. We then developed chromosome idiograms and demonstrated that the X chromosomes exhibit qualitative differences in their pattern of heterochromatic bands and position of satellite DNA (satDNA) repeats among the sibling species with postzygotic isolation, An. arabiensis, An. merus, An. quadriannulatus, and An. coluzzii or An. gambiae. The identified differences in the size and structure of the X chromosome heterochromatin point to a possible role of repetitive DNA in speciation of mosquitoes. We found that An. coluzzii and An. gambiae, incipient species with prezygotic isolation, share variations in the relative positions of the satDNA repeats and the proximal heterochromatin band on the X chromosomes. This previously unknown genetic polymorphism in malaria mosquitoes may be caused by a differential amplification of DNA repeats or an inversion in the sex chromosome heterochromatin.

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Section: Discussionmentioning

confidence: 99%

Structural Variation of the X Chromosome Heterochromatin in the Anopheles gambiae Complex

Sharma

Kinney

Timoshevskiy

et al. 2020

Genes

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“…Theory suggests that chromosomal rearrangements through fusion and fission of existing chromosomes could act as isolating mechanisms because hybrids are predicted to be at least partially sterile (Dion-Côté & Barbash, 2017;King, 1995;White, 1978).…”

Section: Introductionmentioning

confidence: 99%

Secondary contact zones of closely‐related Erebia butterflies overlap with narrow phenotypic and parasitic clines

Butlin

Patsiou

2020

J of Evolutionary Biology

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Zones of secondary contact between closely related taxa are a common legacy of the Quaternary ice ages. Despite their abundance, the factors that keep species apart and prevent hybridization are often unknown. Here, we study a very narrow contact zone between three closely related butterfly species of the Erebia tyndarus species complex. Using genomic data, we first determined whether gene flow occurs and then assessed whether it might be hampered by differences in chromosome number between some species. We found interspecific gene flow between sibling species that differ in karyotype by one chromosome. Conversely, only F1 hybrids occurred between two species that have the same karyotype, forming a steep genomic cline. In a second step, we fitted clines to phenotypic, ecological and parasitic data to identify the factors associated with the genetic cline. We found clines for phenotypic data and the prevalence of the endosymbiont parasite Wolbachia to overlap with the genetic cline, suggesting that they might be drivers for separating the two species. Overall, our results highlight that some gene flow is possible between closely related species despite different chromosome numbers, but that other barriers restrict such gene flow.

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“…This is unlikely since the hybrid genotype is less sensitive than S. paradoxus at the concentration used. We rather hypothesize that in the specific case of stress caused by DNA damage, hybrids may be at a disadvantage because they are genetically unstable (Fontdevila 2005;Marfil et al 2006;Baack & Rieseberg 2007;Morales & Dujon 2012;Guerreiro 2014;Xie et al 2016;Dion-Côté & Barbash 2017;Mwathi et al 2019) and DNA damaging agents may further enhance this instability, preventing the occurrence or fixation of adaptive mutations. Consistent with the instability of hybrids, recent study of mutation accumulation in yeast reported that hybrids from more divergent parents lines were lost at a greater rate than the less divergent ones (Charron et al 2019) .…”

Section: Discussionmentioning

confidence: 99%

“…Certain models and experiments show that increase in mutation rates may accelerate adaptation (Taddei et al 1997;Schaaff et al 2002;Labat et al 2005;Le Bars et al 2014;Bui et al 2015;Couce et al 2017) . Genomic instability includes higher rate of DNA damage (Wang et al 2014;Herbst et al 2017) , chromosomal rearrangements (Baack & Rieseberg 2007;Mwathi et al 2019) , gene and chromosome copy number variation (Morales & Dujon 2012;Dion-Côté & Barbash 2017) and the multiplication of repetitive and transposable elements (Fontdevila 2005;Guerreiro 2014) . These changes often lead to aneuploidy, which has also been shown to be a mechanism of adaptation in stressful conditions (Mulla et al 2014;Sunshine et al 2015) and hybrids may be particularly prone to producing aneuploid progeny (Gilchrist & Stelkens 2019) .…”

Section: Introductionmentioning

confidence: 99%

Interspecific Hybrids Show a Reduced Adaptive Potential Under DNA Damaging Conditions

Bautista

Marsit

Landry

2020

Preprint

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AbstractHybridization may increase the probability of adaptation to extreme stresses. This advantage could be caused by an increased genome plasticity in hybrids, which could accelerate the search for adaptive mutations. High ultraviolet (UV) radiation is a particular challenge in terms of adaptation because it affects the viability of organisms by directly damaging DNA, while also challenging future generations by increasing mutation rate. Here we test if hybridization accelerates adaptive evolution in response to DNA damage, using yeast as a model. We exposed 180 populations of hybrids between species (Saccharomyces cerevisiae and Saccharomyces paradoxus) and their parental strains to UV mimetic and control conditions for approximately 100 generations. Although we found that adaptation occurs in both hybrids and parents, hybrids achieved a lower rate of adaptation, contrary to our expectations. Adaptation to DNA damage conditions comes with a large and similar cost for parents and hybrids, suggesting that this cost is not responsible for the lower adaptability of hybrids. We suggest that the lower adaptive potential of hybrids in this condition may result from the interaction between DNA damage and the inherent genetic instability of hybrids.

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Beyond speciation genes: an overview of genome stability in evolution and speciation

Cited by 65 publications

References 73 publications

Structural Variation of the X Chromosome Heterochromatin in the Anopheles gambiae Complex

Structural Variation of the X Chromosome Heterochromatin in the Anopheles gambiae Complex

Secondary contact zones of closely‐related Erebia butterflies overlap with narrow phenotypic and parasitic clines

Interspecific Hybrids Show a Reduced Adaptive Potential Under DNA Damaging Conditions

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