Beyond Survival in Solid Organ Transplantation: A Summary of Expert Presentations from the Sandoz 6th Standalone Transplantation Meeting, 2018

Legendre, Christophe; Viebahn, Richard; Crespo, Marta; Dor, Frank J. M. F.; Gustafsson, Bengt; Samuel, Undine; Karam, Vincent; Binet, Isabelle; Åberg, Fredrik; Geest, Sabina De; Moes, Dirk Jan A R; Tönshoff, Burkhard; Oppenheimer, F.; Åsberg, Anders; Halleck, Fabian; Loupy, Alexandre; Suesal, Caner

doi:10.1097/tp.0000000000002846

Cited by 7 publications

(11 citation statements)

References 67 publications

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“…This result can be attributed to more prolonged and frequent hospital admission and expectation reduction with anxiety, stress, and depression[ 37 ]. In agreement with the current results, the published literature has observed the positive effects of LT on the recipients’ HRQoL[ 12 , 37 - 40 ].…”

Section: Discussionsupporting

confidence: 92%

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Impact of biliary complications on quality of life in live-donor liver transplant recipients

Guirguis¹,

Nashaat²,

Yassin³

et al. 2021

WJH

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BACKGROUND Despite significant advancements in liver transplantation (LT) surgical procedures and perioperative care, post-LT biliary complications (BCs) remain a significant source of morbidity, mortality, and graft failure. In addition, data are conflicting regarding the health-related quality of life (HRQoL) of LT recipients. Thus, the success of LT should be considered in terms of both the survival and recovery of HRQoL. AIM To assess the impact of BCs on the HRQoL of live-donor LT recipients (LDLT-Rs). METHODS We retrospectively analysed data for 25 LDLT-Rs who developed BCs post-LT between January 2011 and December 2016 at our institution. The Short Form 12 version 2 (SF 12v2) health survey was used to assess their HRQoL. We also included 25 LDLT-Rs without any post-LT complications as a control group. RESULTS The scores for HRQoL of LDLT-Rs who developed BCs were significantly higher than the norm-based scores in the domains of physical functioning ( P = 0.003), role-physical ( P < 0.001), bodily pain ( P = 0.003), general health ( P = 0.004), social functioning ( P = 0.005), role-emotional ( P < 0.001), and mental health ( P < 0.001). No significant difference between the two groups regarding vitality was detected ( P = 1.000). The LDLT-Rs with BCs had significantly lower scores than LDLT-Rs without BCs in all HRQoL domains ( P < 0.001) and the mental ( P < 0.001) and physical ( P = 0.0002) component summary scores. CONCLUSION The development of BCs in LDLT-Rs causes a lower range of improvement in HRQoL.

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Section: Discussionsupporting

confidence: 92%

“…Unfulfillment of these expectations may negatively affect their HRQoL, highlighting the need to help patients expect and understand the outcomes of LT. Moreover, LT candidate education positively affects post-LT HRQoL[ 40 ]. Education is associated with better outcomes and higher patient adherence[ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of biliary complications on quality of life in live-donor liver transplant recipients

Guirguis¹,

Nashaat²,

Yassin³

et al. 2021

WJH

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“…In numerous chronically ill populations, the re-organization of care delivery according to the components of chronic illness management has improved outcomes such as reducing hospital admissions, improving health behaviors or a better quality of life ( 25 ). As researchers and clinicians have already called to adapt follow-up care to the principles of chronic illness management, which better reflects the complex needs of solid organ transplant recipients ( 26 ), our results emphasize the importance of accompanying this process in transplantation by research.…”

Section: Discussionmentioning

confidence: 60%

A National Survey Comparing Patients’ and Transplant Professionals’ Research Priorities in the Swiss Transplant Cohort Study

Beckmann

Mauthner

Schick³

et al. 2022

Transpl Int

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We aimed to identify, assess, compare and map research priorities of patients and professionals in the Swiss Transplant Cohort Study. The project followed 3 steps. 1) Focus group interviews identified patients’ (n = 22) research priorities. 2) A nationwide survey assessed and compared the priorities in 292 patients and 175 professionals. 3) Priorities were mapped to the 4 levels of Bronfenbrenner’s ecological framework. The 13 research priorities (financial pressure, medication taking, continuity of care, emotional well-being, return to work, trustful relationships, person-centredness, organization of care, exercise and physical fitness, graft functioning, pregnancy, peer contact and public knowledge of transplantation), addressed all framework levels: patient (n = 7), micro (n = 3), meso (n = 2), and macro (n = 1). Comparing each group’s top 10 priorities revealed that continuity of care received highest importance rating from both (92.2% patients, 92.5% professionals), with 3 more agreements between the groups. Otherwise, perspectives were more diverse than congruent: Patients emphasized patient level priorities (emotional well-being, graft functioning, return to work), professionals those on the meso level (continuity of care, organization of care). Patients’ research priorities highlighted a need to expand research to the micro, meso and macro level. Discrepancies should be recognized to avoid understudying topics that are more important to professionals than to patients.

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“…Высокий риск развития посттрансплантационных лимфопролиферативных заболеваний (от англ. Post-transplant lymphoproliferative disorder -PTLD), связанный с использованием индукции антителами, направленными против Т-лимфоцитов, почти наверняка связан с интенсивной иммуносупрессией и, как следствие, снижением функций иммунологического надзора [24,25]. Иммуносупрессанты приводят к подавлению иммунитета реципиентов, тем самым снижая противоопухолевую и противовирусную защиту, а также они могут оказывать прямое повреждающее действие на ДНК реципиента (например, азатиоприн повышает риск развития злокачественных новообразований, и особенно плоскоклеточного рака кожи за счет мутагенного эффекта и потенцирования неблагоприятного эффекта ультрафиолетовых лучей) [7,17,26].…”

Section: патогенезunclassified

Post-transplant malignancies in solid organ recipients: development mechanisms and risk factors

Nikulin

Пашков

Якунин

2021

RJTAO

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According to the International Agency for Research on Cancer, there were an estimated 19,292,789 new cancer cases in various localizations and 9,958,133 cancer deaths worldwide in 2020. These frightening figures clearly show that malignancies among the population is a pressing matter. The risk of post-transplant malignancy in solid organ recipients is 2–6-times higher than in the general population. Given the steadily increasing number of solid organ transplants worldwide and the gradual increase in life expectancy among organ recipients, studying the issues concerning risk factors and development mechanisms becomes a crucial task.

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Beyond Survival in Solid Organ Transplantation: A Summary of Expert Presentations from the Sandoz 6th Standalone Transplantation Meeting, 2018

Abstract: is the of cial journal of The Transplantation Society and the International Liver Transplantation Society and is published 12 times a year beginning in January.

Cited by 7 publications

References 67 publications

Impact of biliary complications on quality of life in live-donor liver transplant recipients

Impact of biliary complications on quality of life in live-donor liver transplant recipients

A National Survey Comparing Patients’ and Transplant Professionals’ Research Priorities in the Swiss Transplant Cohort Study

Post-transplant malignancies in solid organ recipients: development mechanisms and risk factors

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