2024
DOI: 10.1002/ange.202404042
|View full text |Cite
|
Sign up to set email alerts
|

Beyond Tertiary Amines: Introducing Secondary Amines by Palladium/Norbornene‐Catalyzed Ortho Amination

Xin Liu,
Qi Zhu,
Guangbin Dong

Abstract: Since the discovery of the palladium/norbornene (Pd/NBE)‐catalyzed ortho amination in 2013, escaping the limitation of only yielding tertiary anilines has been a long‐standing challenge in the past decade. Here, we describe that, by carefully choosing the phosphine ligand and NBE mediator, installation of a N‐mono‐alkylamino group becomes feasible. The reaction tolerates a wide range of aryl iodide substrates and various N‐mono‐tertiary alkylamine‐derived electrophiles. Both ipso alkenylation and alkynylation … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 64 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?