Beyond the joints, the extra-articular manifestations in rheumatoid arthritis

Conforti, Alessandro; Cola, Ilenia Di; Pavlych, Viktoriya; Ruscitti, Piero; Berardicurti, Onorina; Ursini, Francesco; Giacomelli, Roberto; Cipriani, Paola

doi:10.1016/j.autrev.2020.102735

Cited by 213 publications

(142 citation statements)

References 212 publications

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“…The inhibition of this cytokine, whose signaling pathway uses the protein gp130 as a common signal transducer, could impair the host capacity for generating acute phase responses, including Th17 differentiation and long-lived plasma cell generation [36,42,43]. In fact, some clinical data derived from RCTs supports the notion that IL-6-targeting agents increase the risk of infection to a degree similar to TNFis [36,40,52,53]. On the other hand, neutropenia induced by IL-6 inhibition would frequently occur, due to a margination of neutrophils rather than peripheral sequestration.…”

Section: Risk Of Infections In Rmds and Autoinflammatory Disordersmentioning

confidence: 99%

“…RA and SpA are chronic inflammatory diseases, mainly affecting the joint, mediated by autoimmune and inflammatory process [52,53].…”

Section: Incidence and Outcomes Of Covid-19 In Arthritis Patientsmentioning

confidence: 99%

“…More specifically, whereas RA is characterized by predominant peripheral synovial inflammation sustained by autoantibodies and B-and T-lymphocytes mechanisms, SpAs provide a main innate-immunity mediated pathogenesis leading to inflammation of synovial-entheseal structures and axial skeleton. SpA group includes ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis (ReA), enteropathic, and undifferentiated spondylarthritis (uSpA) [52,53]. In patients with RA and SpA, it is recognized that the immunosuppressive therapy and the presence of comorbidities are associated with an increased risk of infections [54][55][56][57].…”

Section: Incidence and Outcomes Of Covid-19 In Arthritis Patientsmentioning

confidence: 99%

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Pathogenic implications, incidence, and outcomes of COVID-19 in autoimmune inflammatory joint diseases and autoinflammatory disorders

et al. 2021

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As the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread rapidly, there are still many unresolved questions of how this virus would impact on autoimmune inflammatory joint diseases and autoinflammatory disorders. The main aim of this paper is to describe the main studies focusing their attention on COVID-19 incidence and outcomes of rheumatoid arthritis (RA), spondylarthritis (SpA), and autoinflammatory disease cohorts. We also revised possible pathogenic mechanisms associated with. Available data suggest that, in patients with RA and SpA, the immunosuppressive therapy, older age, male sex, and the presence of comorbidities (hypertension, lung disease, diabetes, CVD, and chronic renal insufficiency/end-stage renal disease) could be associated with an increased risk of infections and high rate of hospitalization. Other studies have shown that lower odds of hospitalization were associated with bDMARD or tsDMARDs monotherapy, driven largely by anti-TNF therapies. For autoinflammatory diseases, considering the possibility that COVID-19 could be associated with a cytokine storm syndrome, the question of the susceptibility and severity of SARS-CoV-2 infection in patients displaying innate immunity disorders has been raised. In this context, data are very scarce and studies available did not clarify if having an autoinflammatory disorder could be or not a risk factor to develop a more severe COVID-19. Taking together these observations, further studies are likely to be needed to fully characterize these specific patient groups and associated SARS-CoV-2 infection.

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Section: Risk Of Infections In Rmds and Autoinflammatory Disordersmentioning

confidence: 99%

“…RA and SpA are chronic inflammatory diseases, mainly affecting the joint, mediated by autoimmune and inflammatory process [52,53].…”

Section: Incidence and Outcomes Of Covid-19 In Arthritis Patientsmentioning

confidence: 99%

Section: Incidence and Outcomes Of Covid-19 In Arthritis Patientsmentioning

confidence: 99%

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Pathogenic implications, incidence, and outcomes of COVID-19 in autoimmune inflammatory joint diseases and autoinflammatory disorders

et al. 2021

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“…1 It is an autoimmune disease that may present with extra-articular manifestations, such as pulmonary complications and Sjögren's syndrome. 2 Rarely, RA may affect the urinary tract and has different clinical presentations, such as urinary tract infections (UTI), urolithiasis, and even de-novo lower urinary tract symptoms (LUTS). 3 The combination of joint pain, stiffness, and other potential systematic involvement may directly negatively impact the quality of life (QoL) of such patients.…”

Section: Introductionmentioning

confidence: 99%

Lower Urinary Tract Symptoms Among Females with Rheumatoid Arthritis: A Prospective Cross-Sectional Study

Abushamma

Nassar

Najjar

et al. 2021

IJGM

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“…Rheumatoid arthritis (RA), the most common form of chronic inflammatory arthritis, is mainly targeting synovial joints [ 1 , 2 , 3 ]. However, RA is also a systemic autoimmune disease that involves not only joints but other organs such as the lungs, pericardium, sclera, peripheral nerves, skin, and vessels [ 4 , 5 , 6 ]. Untreated RA destroys the articular cartilage and nearby bones, resulting in functional disability [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Posttranslational Modification in Pathogenesis of Rheumatoid Arthritis: Focusing on Citrullination, Carbamylation, and Acetylation

Kwon

2021

IJMS

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Rheumatoid arthritis (RA) is caused by prolonged periodic interactions between genetic, environmental, and immunologic factors. Posttranslational modifications (PTMs) such as citrullination, carbamylation, and acetylation are correlated with the pathogenesis of RA. PTM and cell death mechanisms such as apoptosis, autophagy, NETosis, leukotoxic hypercitrullination (LTH), and necrosis are related to each other and induce autoantigenicity. Certain microbial infections, such as those caused by Porphyromonasgingivalis, Aggregatibacter actinomycetemcomitans, and Prevotella copri, can induce autoantigens in RA. Anti-modified protein antibodies (AMPA) containing anti-citrullinated protein/peptide antibodies (ACPAs), anti-carbamylated protein (anti-CarP) antibodies, and anti-acetylated protein antibodies (AAPAs) play a role in pathogenesis as well as in prediction, diagnosis, and prognosis. Interestingly, smoking is correlated with both PTMs and AMPAs in the development of RA. However, there is lack of evidence that smoking induces the generation of AMPAs.

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Beyond the joints, the extra-articular manifestations in rheumatoid arthritis

Cited by 213 publications

References 212 publications

Pathogenic implications, incidence, and outcomes of COVID-19 in autoimmune inflammatory joint diseases and autoinflammatory disorders

Pathogenic implications, incidence, and outcomes of COVID-19 in autoimmune inflammatory joint diseases and autoinflammatory disorders

Lower Urinary Tract Symptoms Among Females with Rheumatoid Arthritis: A Prospective Cross-Sectional Study

Impact of Posttranslational Modification in Pathogenesis of Rheumatoid Arthritis: Focusing on Citrullination, Carbamylation, and Acetylation

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