BG126 ® phytodrug improves urinary tract infection treatment with nitrofurantoin in adult women in a double-blind randomized clinical trial

Letelier, María Eugenia; Hidalgo-Castro, F.; López-Valladares, Miguel; Ibacache, N.; Pérez, Carolina; Brunner, Jürgen; González, Javier Ernesto Barreras; Gutmann, R A; Lazo-Henríquez, C.; Gallardo-Garrido, Carlos; Molina-Berríos, Alfredo; Ossandón, Enrique

doi:10.1016/j.hermed.2017.03.001

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…It is essential to highlight that the antimicrobial properties of a natural extract can be a result of the activity of specific compounds and synergistic interactions between said compounds. Here, we used catechin to standardize the BG extract concentrations ( Letelier et al, 2012 ; Letelier et al, 2017 ; Zamorano-Aguilar et al, 2020 ). This flavonoid has shown antimicrobial properties and synergism with antibiotics against Gram-positive and Gram-negative bacteria ( Gomes et al, 2018 ; Ibitoye and Ajiboye, 2019 ; Zhang et al, 2021 ), and the reported MIC of pure catechin against S. aureus was around 78–156 μg/ml ( Zhang et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Spray drying has been used to encapsulate natural extracts showing great stability when stored in closed containers at room temperature ( Cortes-Rojas et al, 2016 ). Additionally, these dry powder formulations can be used within capsules for oral administration ( Letelier et al, 2017 ), to study their performance for inhalation delivery ( Shetty et al, 2020 ), or used as ingredients for solutions or semisolid antimicrobial formulations for future applications. However, considering the poor flowability exhibited by the formulations, this property should be optimized for dosage forms that require fast filling steps, such as hard capsules or tableting, to prevent dose variability.…”

Section: Discussionmentioning

confidence: 99%

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Formulation of water-soluble Buddleja globosa Hope extracts and characterization of their antimicrobial properties against Pseudomonas aeruginosa

Araya

Leiva-Soto²,

Bruna³

et al. 2022

Front. Pharmacol.

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Buddleja globosa Hope (BG) extracts are traditionally used to treat skin and gastric ulcers due to their healing properties. Non-aqueous solvents such as ethanol and DMSO are usually used to extract naturally occurring compounds. However, the cytotoxicity of these solvents and the low water solubility of the extracted compounds can hinder their biomedical applications. To overcome the limited solubility of the BG extracts, we aimed to enhance the solubility by processing a standardized hydroalcoholic extract (BG-126) through spray drying (SD), with and without two solubility enhancers. Spray-dried BG (BG-SD) extracts and spray-dried BG extracts plus polyvinylpyrrolidone (BG-SD PVP) and Soluplus® (BG-SD SP) were developed starting from BG-126 (containing 53% ethanol). These four formulations were characterized by total phenolic content, water solubility at 25°C and 37°C, and antimicrobial properties against Pseudomonas aeruginosa. All the SD formulations presented a solubility that allowed them to reach maximum concentrations of 1,024 μg/ml catechin for BG-SD and 2,048 μg/ml catechin for BG-SD PVP and BG-SD SP for antimicrobial testing. BG-SD showed the highest antimicrobial potency with a minimum inhibitory concentration (MIC) of 512 μg/ml catechin, followed by BG-126 with a MIC of 1,024 μg/ml catechin and SP. BG-126 was also shown to inhibit biofilm formation, as well as the excipients PVP and SP. The spray-dried BG (BG-SD) extract represents a promising natural active component with enhanced antimicrobial properties against P. aeruginosa for further research and the development of novel phytopharmaceuticals.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Formulation of water-soluble Buddleja globosa Hope extracts and characterization of their antimicrobial properties against Pseudomonas aeruginosa

Araya

Leiva-Soto²,

Bruna³

et al. 2022

Front. Pharmacol.

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“…NFT is an antimicrobial drug for the treatment of lower urinary tract infections, which displays adverse effects related to oxidative stress generated by the enzymatic reduction of NFT. A double-blind randomized-trial at the Hospital Clínico Universidad de Chile demonstrated that extract BG1261® controls the oxidative stress and improves the quality of life of patients during treatment [11].…”

Section: Modern Applications Of Bioequivalence and Bioavailabilitymentioning

confidence: 99%

Modern Molecules to Keep Ancient Traditions: Ethical and Social Perspectives

AD¹

2018

MABB

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Robust and selective electrochemical detection of antibiotic residues: The case of integrated lutetium vanadate/graphene sheets architectures

Kokulnathan

Chen

2020

Journal of Hazardous Materials

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BG126 ® phytodrug improves urinary tract infection treatment with nitrofurantoin in adult women in a double-blind randomized clinical trial

Cited by 5 publications

References 37 publications

Formulation of water-soluble Buddleja globosa Hope extracts and characterization of their antimicrobial properties against Pseudomonas aeruginosa

Formulation of water-soluble Buddleja globosa Hope extracts and characterization of their antimicrobial properties against Pseudomonas aeruginosa

Modern Molecules to Keep Ancient Traditions: Ethical and Social Perspectives

Robust and selective electrochemical detection of antibiotic residues: The case of integrated lutetium vanadate/graphene sheets architectures

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