2007
DOI: 10.4137/tog.s436
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bHLH-Orange Transcription Factors in Development and Cancer

Abstract: Basic helix-loop-helix (bHLH) proteins are a large superfamily of transcription factors that play critical roles in many physiological processes including cellular differentiation, cell cycle arrest and apoptosis. Based on structural and phylogenetic analysis, mammalian bHLH-Orange (bHLH-O) proteins, which constitute the repressor family of bHLH factors, can be grouped into four subfamilies: Hes, Hey, Helt and Stra13/Dec. In addition to the bHLH domain that mediates DNA-binding and protein dimerization, all me… Show more

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Cited by 42 publications
(18 citation statements)
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References 121 publications
(168 reference statements)
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“…The latter is transported to the nucleus, where it binds to multiple transcription cofactors causing expression of Notch target genes, including hairy enhance of split-1family (Hes-1) and related family (Hey-1), nuclear factor-kappa B (NF-κB), cyclin D1, and c-Myc ( Miele and Osborne, 1999 , Miele, 2006 , Miele et al, 2006 , Miele et al, 2006 , Miele, 2006 ). Thus, the Notch pathway includes several processes involved in oncogenesis, such as cell proliferation and growth, metastasis, anti-apoptosis ( Sun et al, 2007 , Maniati et al, 2011 , Wang et al, 2015 ), and angiogenesis ( Zeng et al, 2005 ).…”
Section: Introductionmentioning
confidence: 99%
“…The latter is transported to the nucleus, where it binds to multiple transcription cofactors causing expression of Notch target genes, including hairy enhance of split-1family (Hes-1) and related family (Hey-1), nuclear factor-kappa B (NF-κB), cyclin D1, and c-Myc ( Miele and Osborne, 1999 , Miele, 2006 , Miele et al, 2006 , Miele et al, 2006 , Miele, 2006 ). Thus, the Notch pathway includes several processes involved in oncogenesis, such as cell proliferation and growth, metastasis, anti-apoptosis ( Sun et al, 2007 , Maniati et al, 2011 , Wang et al, 2015 ), and angiogenesis ( Zeng et al, 2005 ).…”
Section: Introductionmentioning
confidence: 99%
“…Stra13, a member of the bHLH-O repressor subfamily is widely expressed both during embryonic development as well as in a number of adult tissues [1] , [2] . In addition to being constitutively expressed in several cell types, its expression is up regulated in response to multiple stimuli including retinoic acid, TGFβ, serum deprivation, genotoxic agents and trichostatin A (TSA).…”
Section: Introductionmentioning
confidence: 99%
“…Consistent with these observations, Stra13 expression is indeed down regulated in some tumors. Intriguingly however, it is also overexpressed in many cancers [2] , [18] [22] . Similarly, while Stra13 inhibits differentiation of some cell types, it promotes others [3] , [8] , [9] .…”
Section: Introductionmentioning
confidence: 99%
“…DEC2 is one of the basic helix- loop-helix-Orange transcription factors, featured with a basic DNA binding domain, a helix-loop-helix (HLH) dimerization domain, and Orange extended dimerization domain [ 27 ]. And it has been implicated in regulating many types of biochemical processes, including circadian rhythm [ 28 ], cell proliferation and differentiation [ 29 ], apoptosis, hypoxia response, and EMT of tumor cells [ 28 , 30 ].…”
Section: Discussionmentioning
confidence: 99%