BHLHE22 Expression Is Associated with a Proinflammatory Immune Microenvironment and Confers a Favorable Prognosis in Endometrial Cancer

Darmawi,; Chen, Lin-Yu; Su, Po-Hsuan; Liew, Phui Ly; Wang, Hui-Chen; Weng, Yu-Chun; Huang, Rui-Lan; Lai, Hung-Cheng

doi:10.3390/ijms23137158

Cited by 3 publications

(1 citation statement)

References 48 publications

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“…There is mounting evidence that the occurrence, growth and metastasis of UCEC are very intertwined with the immune microenvironment [34][35][36]. LAMP3 expression has been reported to influence the prognosis of lung adenocarcinoma by regulating the infiltration levels of B cells, dendritic cells, natural killer cells, and eosinophils [37].…”

Section: Discussionmentioning

confidence: 99%

LAMP3 is a potent uterine corpus endometrial carcinoma prognostic biomarker associated with immune behavior

Fu,

Zhou,

Geng

et al. 2024

Aging

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Background: Uterine corpus endometrial carcinoma (UCEC) is one of the most common gynecological malignancies and its incidence and mortality continue apace. Lysosome-associated membrane protein 3 (LAMP3) is the third member of the LAMP family and its overexpression has been described to be involved in the progression of breast, ovarian and cervical cancers, but there has been an absence of research focusing on its role in UCEC. Methods: WGCNA, TIMER, LinkedOmics, GSEA, Cytoscape, Kaplan-Meier plotter, GDC, GeneMANIA, cBioPortal, PDB, RNAinter, miRNet were applied in this research. Results: Our study uncovers that LAMP3 possesses higher expression levels in UCEC compared to normal tissues, and this differential expression profile is tightly aligned with clinical and pathological features, and patients demonstrating high LAMP3 expression tend to have a shorter survival expectancy. The high expression of LAMP3 is modulated by the designated ceRNA network. LAMP3 is engaged in UCEC progression by functioning in a variety of biological roles of relevance to immunity. Furthermore, we predicted several prospering drugs based on drug sensitivity. Finally, we also constructed possible docking patterns of LAMP3 with ABCA3, RAB9A, and SGTB. Conclusions: LAMP3 is a formidable biomarker for UCEC and could be a prospective candidate for the diagnosis, treatment and prognostic assessment of UCEC.

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Section: Discussionmentioning

confidence: 99%

LAMP3 is a potent uterine corpus endometrial carcinoma prognostic biomarker associated with immune behavior

Fu,

Zhou,

Geng

et al. 2024

Aging

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Transposable element 5mC methylation state of blood cells predicts age and disease

Morandini,

Lu,

Rechsteiner

et al. 2024

Nat Aging

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Genetic polymorphisms of PKLR gene and their associations with milk production traits in Chinese Holstein cows

Zhao²,

Liu

et al. 2022

Front. Genet.

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Our previous work had confirmed that pyruvate kinase L/R (PKLR) gene was expressed differently in different lactation periods of dairy cattle, and participated in lipid metabolism through insulin, PI3K-Akt, MAPK, AMPK, mTOR, and PPAR signaling pathways, suggesting that PKLR is a candidate gene to affect milk production traits in dairy cattle. Here, we verified whether this gene has significant genetic association with milk yield and composition traits in a Chinese Holstein cow population. In total, we identified 21 single nucleotide polymorphisms (SNPs) by resequencing the entire coding region and partial flanking region of PKLR gene, in which, two SNPs were located in 5′ promoter region, two in 5′ untranslated region (UTR), three in introns, five in exons, six in 3′ UTR and three in 3′ flanking region. The single marker association analysis displayed that all SNPs were significantly associated with milk yield, fat and protein yields or protein percentage (p ≤ 0.0497). The haplotype block containing all the SNPs, predicted by Haploview, had a significant association with fat yield and protein percentage (p ≤ 0.0145). Further, four SNPs in 5′ regulatory region and eight SNPs in UTR and exon regions were predicted to change the transcription factor binding sites (TFBSs) and mRNA secondary structure, respectively, thus affecting the expression of PKLR, leading to changes in milk production phenotypes, suggesting that these SNPs might be the potential functional mutations for milk production traits in dairy cattle. In conclusion, we demonstrated that PKLR had significant genetic effects on milk production traits, and the SNPs with significant genetic effects could be used as candidate genetic markers for genomic selection (GS) in dairy cattle.

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BHLHE22 Expression Is Associated with a Proinflammatory Immune Microenvironment and Confers a Favorable Prognosis in Endometrial Cancer

Cited by 3 publications

References 48 publications

LAMP3 is a potent uterine corpus endometrial carcinoma prognostic biomarker associated with immune behavior

LAMP3 is a potent uterine corpus endometrial carcinoma prognostic biomarker associated with immune behavior

Transposable element 5mC methylation state of blood cells predicts age and disease

Genetic polymorphisms of PKLR gene and their associations with milk production traits in Chinese Holstein cows

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