Biased coin designs: some properties and applications

Eisele, Jeffrey R.

doi:10.1214/lnms/1215451477

Cited by 5 publications

(7 citation statements)

References 19 publications

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“…By using martingale methods and the law of the iterated logarithm, we prove asymptotic normality of allocation proportions under some general conditions. It is shown that the allocation function of the example in Eisele (1994Eisele ( , 1995 satisfies the conditions here.…”

Section: Preliminariesmentioning

confidence: 78%

“…Eisele and Woodroofe (1995) studied the asymptotic properties of doubly adaptive biased coin designs (for two treatments) under some very restrictive conditions on allocation functions. Indeed, as pointed out by Melfi, Page and Geraldes (2001): "the example given in their papers [Eisele (1994[Eisele ( , 1995] makes use of an allocation function which does not even satisfy these conditions! "…”

Section: Preliminariesmentioning

confidence: 99%

“…In fact, Melfi, Page and Geraldes (2001) pointed out that the function g(x, y) = [1 − (1/y − 1)x] + [cf. Eisele (1994Eisele ( , 1995] does not satisfy condition (iv). This is because ∂g/∂x| y=x = 1 − 1/x is not bounded.…”

Section: Doubly Adaptive Biased Coin Design (Dbcd) For Two Treatmentsmentioning

confidence: 99%

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Asymptotic properties of doubly adaptive biased coin designs for multitreatment clinical trials

Hu¹,

Zhang²

2004

Ann. Statist.

138

150

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A general doubly adaptive biased coin design is proposed for the allocation of subjects to K treatments in a clinical trial. This design follows the same spirit as Efron's biased coin design and applies to the cases where the desired allocation proportions are unknown, but estimated sequentially. Strong consistency, a law of the iterated logarithm and asymptotic normality of this design are obtained under some widely satisfied conditions. For two treatments, a new family of designs is proposed and shown to be less variable than both the randomized play-the-winner rule and the adaptive randomized design. Also the proposed design tends toward a randomization scheme (with a fixed target proportion) as the size of the experiment increases.

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Section: Preliminariesmentioning

confidence: 78%

Section: Preliminariesmentioning

confidence: 99%

See 1 more Smart Citation

Asymptotic properties of doubly adaptive biased coin designs for multitreatment clinical trials

Hu¹,

Zhang²

2004

Ann. Statist.

138

150

View full text Add to dashboard Cite

show abstract

“…Biased coin designs are used when researchers need to balance the number of subjects in each treatment condition-which is often not achieved with conventional coin designs. This form of randomization ensures that a certain minimum number of subjects gets randomized to the treatment condition [16]. In this study, two randomization protocols are applied, each of which depends on the number of active participants.…”

Section: Randomization and Sample Sizementioning

confidence: 99%

Methods of a multisite randomized clinical trial of supported employment among veterans with spinal cord injury

Ottomanelli¹,

Goetz²,

McGeough³

et al. 2009

JRRD

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Abstract-This article compares the methods of a randomized multisite clinical trial of evidence-based supported employment with conventional vocational rehabilitation among veterans with spinal cord injury (SCI). The primary hypothesis is that, compared with conventional vocational rehabilitation (i.e., standard care), evidence-based supported employment will significantly improve competitive employment outcomes and general rehabilitation outcomes. The secondary hypothesis is that evidencebased supported employment in SCI will be more cost-effective than standard care. The current article describes the clinical trial and presents baseline data. The present sample includes 301 veterans with SCI, which includes paraplegia (50%), high tetraplegia (32%), and low tetraplegia (18%). Baseline data indicate that 65% of this sample of employment-seeking veterans with SCI had never been employed postinjury, despite the fact that nearly half (41%) had received some type of prior vocational rehabilitation. These rates of unemployment for veterans with SCI are consistent with the rates reported for community samples of persons with SCI. Forthcoming outcome data will provide much needed insights into the best practices for helping these veterans restore vocational goals and improve overall quality of life. Clinical

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“…Bu süreç her bir atama işleminde tekrarlanmaktadır. Bu yöntemin aşamaları aşağıda adımlar halinde verilmektedir 4,9,[11][12][13] .…”

Section: Introductionunclassified

Randomization In Clinical Trials

Kanik¹,

Taşdelen²,

Erdoğan³

2011

MMJ

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Biased coin designs: some properties and applications

Cited by 5 publications

References 19 publications

Asymptotic properties of doubly adaptive biased coin designs for multitreatment clinical trials

Asymptotic properties of doubly adaptive biased coin designs for multitreatment clinical trials

Methods of a multisite randomized clinical trial of supported employment among veterans with spinal cord injury

Randomization In Clinical Trials

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